The Naked Scientists

The Naked Scientists Forum

Author Topic: Is THC a potential antiglutamatergic drug?  (Read 339 times)

Offline tkadm30

  • Hero Member
  • *****
  • Posts: 914
  • Thanked: 7 times
    • View Profile
    • IsotopeSoftware
Is THC a potential antiglutamatergic drug?
« on: 19/07/2016 20:19:08 »
Is THC a potential antiglutamatergic drug?


 

Offline chris

  • Neilep Level Member
  • ******
  • Posts: 5336
  • Thanked: 65 times
  • The Naked Scientist
    • View Profile
    • The Naked Scientists
Re: Is THC a potential antiglutamatergic drug?
« Reply #1 on: 19/07/2016 22:07:26 »
Why do you ask? I enquire since I am unaware of the pharmacology of the agent at receptors other than cannabinoid receptors; do you have reason for suspecting that it might have affinity at glutamatergic sites?
 

Offline tkadm30

  • Hero Member
  • *****
  • Posts: 914
  • Thanked: 7 times
    • View Profile
    • IsotopeSoftware
Re: Is THC a potential antiglutamatergic drug?
« Reply #2 on: 19/07/2016 23:09:22 »
Why do you ask? I enquire since I am unaware of the pharmacology of the agent at receptors other than cannabinoid receptors; do you have reason for suspecting that it might have affinity at glutamatergic sites?

Have a look at this paper. It seems THC may downregulate glutamate signaling and depresses glutamatergic synaptic transmission. A potential neuroprotective mecanism I suppose to prevent glutamate-induced excitotoxicity?

http://www.ncbi.nlm.nih.gov/pubmed/26987641
 

The Naked Scientists Forum

Re: Is THC a potential antiglutamatergic drug?
« Reply #2 on: 19/07/2016 23:09:22 »

 

SMF 2.0.10 | SMF © 2015, Simple Machines
SMFAds for Free Forums