The Naked Scientists

The Naked Scientists Forum

Author Topic: What is the Gulf War syndrome?  (Read 1685 times)

Offline tkadm30

  • Hero Member
  • *****
  • Posts: 916
  • Thanked: 7 times
    • View Profile
    • IsotopeSoftware
What is the Gulf War syndrome?
« on: 17/08/2016 13:18:16 »
A study has found evidences of the health effects of aerosolized jet fuel on the pathology of the gulf war syndrome (GWS): http://www.tandfonline.com/doi/abs/10.1080/027868201753306714

Why is there no formal definition of this medical condition??

Furthermore, the effects of aerosolized jet fuel on chronic inflammation of the CNS are poorly understood and more research should be done to clarify the immunotoxicity of nanoparticles exposure:

https://en.wikipedia.org/wiki/Gulf_War_syndrome#Chronic_inflammation


 

Offline exothermic

  • Sr. Member
  • ****
  • Posts: 482
  • Thanked: 22 times
    • View Profile
Re: What is the Gulf War syndrome?
« Reply #1 on: 17/08/2016 15:18:59 »
A study has found evidences of the health effects of aerosolized jet fuel on the pathology of the gulf war syndrome (GWS)

Why is there no formal definition of this medical condition??

The reason there is no definite serology, histology, hematology or pathology defined for Gulf War Illness is due to the fact that the symptoms are of various nonbiologic and/or biologic etiologies. Much like patients who are falsely diagnosed with "Chronic Fatigue Syndrome", a strikingly high percentage i.e. 40% of GWI patients had recurring mycoplasma/bacterial infections. The remaining patients have symptoms which are believed to be a result of toxicological insult during wartime.

Quote
Gulf War Illness Research - Institute for Molecular Medicine

Although there is not yet a case definition for Gulf War Illness, the chronic signs and symptoms loosely fit the clinical criteria for Chronic Fatigue Syndrome and/or Fibromyalgia Syndrome.

A rather large subset (~40%) of GWI patients have transmittible infections, including mycoplasmal and possibly other chronic bacterial infections, that have resulted in the appearance of GWI in immediate family members and civilians in the Gulf region.

Some patients have additionally what appears to be neurotoxicity and brainstem dysfunction that can result in autonomic, cranial and peripheral nerve demyelination, possibly due to complex chemical exposures. Often these patients have been diagnosed with Multiple Chemical Sensitivity Syndrome (MCS) or Organophosphate-Induced Delayed Neurotoxicity (OPIDN). Chemically exposed patients can be treated by removal of offending chemicals from the patient's environment, depletion of chemicals from the patient's system and treatment of the neurotoxic signs and symptoms caused by chemical exposure(s).

http://www.immed.org/illness/gulfwar_illness_research.html

Quote from: exothermic
excerpt from:
Infectious Diseases as the Underlying Cause of CFS
by Kent Holtorf, M.D.


Numerous studies have demonstrated a high incidence of chronic infections in chronic fatigue syndrome. These include viral infections of Epstein Barr (EBV), cytomegalovirus (CMV), human herpes virus-6, (HHV-6), and bacterial infections such as mycoplasma, chlamydia pneumonia (CP) and Borrelia burgdorferi (Lyme disease).

A study published in Acta Pathologica, Microbiologica et Immunologica Scandinavica found that 52% of CFS patients had active mycoplamsa infection, 30.5% had active HHV-6 infection, and 7.5% had Chlamydia pneumonia infections vs. only 6%, 9% and 1% of controls, respectively.

Another study published in the Journal Immunology and Medical Microbiology also confirmed there is a high incidence of active mycoplasma infection among European CFS patients. It was revealed that 68% of these patients had an active mycoplasma infection as diagnosed with specialized polymerase chain reaction (PCR) testing.
 

Offline exothermic

  • Sr. Member
  • ****
  • Posts: 482
  • Thanked: 22 times
    • View Profile
Re: What is the Gulf War syndrome?
« Reply #2 on: 17/08/2016 15:42:49 »
Furthermore, the effects of aerosolized jet fuel on chronic inflammation of the CNS are poorly understood and more research should be done to clarify the immunotoxicity of nanoparticles exposure:

I'm fairly certain the amount of total systemic exposure would be minimal [unless large amounts were inhaled] and any degree of immunotoxicity would be transient. I don't believe any potential effects on the CNS from low volume exposure to aerosolized jet fuel would be permanent.
 

Offline chiralSPO

  • Global Moderator
  • Neilep Level Member
  • *****
  • Posts: 1875
  • Thanked: 143 times
    • View Profile
Re: What is the Gulf War syndrome?
« Reply #3 on: 17/08/2016 16:58:18 »
Furthermore, the effects of aerosolized jet fuel on chronic inflammation of the CNS are poorly understood and more research should be done to clarify the immunotoxicity of nanoparticles exposure:

I'm fairly certain the amount of total systemic exposure would be minimal [unless large amounts were inhaled] and any degree of immunotoxicity would be transient. I don't believe any potential effects on the CNS from low volume exposure to aerosolized jet fuel would be permanent.

Furthermore, if it were an issue of aerosolized jet fuel, why isn't there a tarmac syndrome? The Gulf War was very short compared to the average tenure of someone working the tarmac at an airport...

 

Offline tkadm30

  • Hero Member
  • *****
  • Posts: 916
  • Thanked: 7 times
    • View Profile
    • IsotopeSoftware
Re: What is the Gulf War syndrome?
« Reply #4 on: 17/08/2016 17:07:53 »
Furthermore, if it were an issue of aerosolized jet fuel, why isn't there a tarmac syndrome? The Gulf War was very short compared to the average tenure of someone working the tarmac at an airport...

There's a quite logical explanation to this. Commercial aircrafts don't use the same jet fuel than military aircrafts.

Moreover I believe the Gulf War syndrome is underdiagnosed.
« Last Edit: 17/08/2016 17:48:13 by tkadm30 »
 

Offline tkadm30

  • Hero Member
  • *****
  • Posts: 916
  • Thanked: 7 times
    • View Profile
    • IsotopeSoftware
Re: What is the Gulf War syndrome?
« Reply #5 on: 17/08/2016 17:28:16 »
Besides, the aerosolized jet fuel is likely released once the plane is in flight, not at the tarmac.

 

Offline exothermic

  • Sr. Member
  • ****
  • Posts: 482
  • Thanked: 22 times
    • View Profile
Re: What is the Gulf War syndrome?
« Reply #6 on: 17/08/2016 20:41:41 »
A study has found evidences of the health effects of aerosolized jet fuel on the pathology of the gulf war syndrome (GWS): http://www.tandfonline.com/doi/abs/10.1080/027868201753306714

That study merely consists of a chemical composition assay to determine the amount of environmental toxins released from  kerosene heaters in an enclosed space. Nowhere is it implied that aerosolized jet fuel is a causative agent in the pathogenesis of GWI.

 

Offline exothermic

  • Sr. Member
  • ****
  • Posts: 482
  • Thanked: 22 times
    • View Profile
Re: What is the Gulf War syndrome?
« Reply #7 on: 17/08/2016 20:50:27 »
When compared to aerosolized jet fuel, there are far more toxic compounds that the Gulf War soldiers were exposed to.

Quote
Some patients have additionally what appears to be neurotoxicity and brainstem dysfunction that can result in autonomic, cranial and peripheral nerve demyelination, possibly due to complex chemical exposures. Often these patients have been diagnosed with Multiple Chemical Sensitivity Syndrome (MCS) or Organophosphate-Induced Delayed Neurotoxicity (OPIDN). Chemically exposed patients can be treated by removal of offending chemicals from the patient's environment, depletion of chemicals from the patient's system and treatment of the neurotoxic signs and symptoms caused by chemical exposure(s).

http://www.immed.org/illness/gulfwar_illness_research.html
 

Offline tkadm30

  • Hero Member
  • *****
  • Posts: 916
  • Thanked: 7 times
    • View Profile
    • IsotopeSoftware
Re: What is the Gulf War syndrome?
« Reply #8 on: 17/08/2016 20:54:28 »
That study merely consists of a chemical composition assay to determine the amount of environmental toxins released from  kerosene heaters in an enclosed space. Nowhere is it implied that aerosolized jet fuel is a causative agent in the pathogenesis of GWI.

The result is the same. Both a kerosene heater or the exhaust of an aircraft produces aerosolized nanoparticles and aromatic hydrocarbons. Also, jet fuel-induced immunotoxicity has been investigated in this study: http://www.ncbi.nlm.nih.gov/pubmed/11693943

 

Offline exothermic

  • Sr. Member
  • ****
  • Posts: 482
  • Thanked: 22 times
    • View Profile
Re: What is the Gulf War syndrome?
« Reply #9 on: 18/08/2016 00:47:15 »
Both produce aerosolized nanoparticles and aromatic hydrocarbons.

Where is the evidence demonstrating that either of the two are pathologic factors in GWI? You said that's what the study found.


Also, jet fuel-induced immunotoxicity has been investigated in this study: http://www.ncbi.nlm.nih.gov/pubmed/11693943

...... In mice, under experimental conditions that do not reflect what has been reported in humans. There are some valid discrepancies within the peer-reviewed literature about the validity of the author's methodologies. Nonetheless, it hasn't been extrapolated to humans that I'm aware of.


Quote from: Toxicologic Assessment of Jet-Propulsion Fuel 8. National Research Council (US) Subcommittee on Jet-Propulsion Fuel 8

In military personnel exposed to JP-8, tank-entry workers, considered to be among the most highly exposed population, were found to have higher white-blood-cell counts than a low-exposure group (Rhodes et al. 2001). Differential analyses revealed increased numbers of neutrophils and monocytes but no differences in total numbers of lymphocytes, T cells, NK cells, or B cells.

Those findings suggest that JP-8 exposure might induce an inflammatory response in humans but do not corroborate the decrease in immune-cell numbers seen in mice. It is important to note that the increase in white-blood-cells, neutrophils, and monocytes in the military personnel exposed to JP-8 did not exceed the normal ranges.

No published studies have shown that in vivo immune responses or resistance to infectious disease challenges were altered in JP-8-exposed people.
 

Offline tkadm30

  • Hero Member
  • *****
  • Posts: 916
  • Thanked: 7 times
    • View Profile
    • IsotopeSoftware
Re: What is the Gulf War syndrome?
« Reply #10 on: 18/08/2016 02:25:19 »
Where is the evidence demonstrating that either of the two are pathologic factors in GWI? You said that's what the study found.

The study put forward the hypothesis that environmental exposure to burning jet fuels may have contributed to the Gulf War syndrome pathology.

Digging deeper, we can assert that JP-8 jet fuel exposure is implicated in the pathogenesis of this illness:

Quote
These data on unhealthy Gulf veterans show an acceleration of divided attention task performance over the course of repeated low-level JP-8 exposures. The present faster reaction times are consistent with rat neurobehavioral studies on environmental toxicant cross-sensitization and nonlinear dose-response patterns with stimulant drugs, as well as some previous civilian studies using other exposure agents. Together with previous research findings, the data suggest involvement of central nervous system dopaminergic pathways in affected Gulf veterans.
http://www.ncbi.nlm.nih.gov/pubmed/16385767
 

Offline exothermic

  • Sr. Member
  • ****
  • Posts: 482
  • Thanked: 22 times
    • View Profile
Re: What is the Gulf War syndrome?
« Reply #11 on: 18/08/2016 16:06:05 »
The study put forward the hypothesis

Precisely.


we can assert that JP-8 jet fuel exposure is implicated in the pathogenesis of this illness

Well anybody can assert, but there is no evidence which concludes that average JP-8 exposure is involved in the pathogenesis of Gulf War Illness.

 

Offline exothermic

  • Sr. Member
  • ****
  • Posts: 482
  • Thanked: 22 times
    • View Profile
Re: What is the Gulf War syndrome?
« Reply #12 on: 18/08/2016 16:27:36 »
Digging deeper, we can assert that JP-8 jet fuel exposure is implicated in the pathogenesis of this illness:

Quote
These data on unhealthy Gulf veterans show an acceleration of divided attention task performance over the course of repeated low-level JP-8 exposures. The present faster reaction times are consistent with rat neurobehavioral studies on environmental toxicant cross-sensitization and nonlinear dose-response patterns with stimulant drugs, as well as some previous civilian studies using other exposure agents. Together with previous research findings, the data suggest involvement of central nervous system dopaminergic pathways in affected Gulf veterans.
http://www.ncbi.nlm.nih.gov/pubmed/16385767

The patients were already unhealthy and chronically suffering from multiple chemical sensitivity and/or idiopathic environmental intolerance prior to the start of the study. Additionally, the test merely evaluated reaction times on a visual divided attention test. JP-8 concentrations were not assessed in blood or tissue. This study does nothing to support your implication.
 

Offline exothermic

  • Sr. Member
  • ****
  • Posts: 482
  • Thanked: 22 times
    • View Profile
Re: What is the Gulf War syndrome?
« Reply #13 on: 18/08/2016 20:28:34 »
Digging deeper, we can assert that JP-8 jet fuel exposure is implicated in the pathogenesis of this illness:
Quote

"No published studies have shown that in vivo immune responses or resistance to infectious disease challenges were altered in JP-8-exposed people."
 

Offline tkadm30

  • Hero Member
  • *****
  • Posts: 916
  • Thanked: 7 times
    • View Profile
    • IsotopeSoftware
Re: What is the Gulf War syndrome?
« Reply #14 on: 21/08/2016 23:37:03 »
The study put forward the hypothesis

Precisely.


we can assert that JP-8 jet fuel exposure is implicated in the pathogenesis of this illness

Well anybody can assert, but there is no evidence which concludes that average JP-8 exposure is involved in the pathogenesis of Gulf War Illness.

If the Gulf War Illness is characterized by pulmonary inflammation (constrictive bronchiolitis) then we can postulate that JP-8 aerosol exposure is involved in the chronic inflammation of the lungs:

Quote
Effects of Jet-Propulsion Fuel 8 on the Respiratory Tract
http://www.ncbi.nlm.nih.gov/books/NBK207624/

However, several animal studies conducted in F344 rats and C57BL/6 mice suggest that mixtures of JP-8 vapors and aerosols can result in pulmonary inflammation and alterations in pulmonary functions. Toxic effects have been reported in C57BL/6 mice exposed at concentrations as low as 50 mg/m3 for 1 hr per day for 7 days. The results from those studies suggest that JP-8 aerosol is more toxic to the respiratory tract than JP-8 vapor.

See also: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3296566/
 

Offline exothermic

  • Sr. Member
  • ****
  • Posts: 482
  • Thanked: 22 times
    • View Profile
Re: What is the Gulf War syndrome?
« Reply #15 on: 22/08/2016 22:15:24 »
If the Gulf War Illness is characterized by pulmonary inflammation (constrictive bronchiolitis)

I've only heard about a small subset of GWI patients with constrictive bronchiolitis within the literature. Nonetheless, I don't recall JP-8 being implicated....

"It is likely that veterans of the Gulf War who are ill with GWI owe their illnesses to a variety of exposures: (a) chemical mixtures, primarily organophosphates, antinerve agents and possibly nerve agents, (b) radiological sources, primarily depleted uranium and possibly fallout from destroyed nuclear reactors, and (c) biological sources, primarily bacteria, viruses and toxins, before, during and after the conflict."

http://www.immed.org/illness/gulfwar_illness_research.html

~
 

Offline tkadm30

  • Hero Member
  • *****
  • Posts: 916
  • Thanked: 7 times
    • View Profile
    • IsotopeSoftware
Re: What is the Gulf War syndrome?
« Reply #16 on: 12/09/2016 18:14:22 »
How do you explain the cases of GWS and CFS in North America?

Note that North America is not a battlefield like Syria, however clandestine geoengineering activity is probably occuring in both friendly territories and in theaters of war. Thus I believe this militarized program of stratospheric aerosol injection could be implicated in the pathology of the gulf war syndrome.

So, please tell me exothermic, do you think clandestine geoengineering exists and is affecting us all?
 

Offline exothermic

  • Sr. Member
  • ****
  • Posts: 482
  • Thanked: 22 times
    • View Profile
Re: What is the Gulf War syndrome?
« Reply #17 on: 14/09/2016 10:05:03 »
How do you explain the cases of GWS and CFS in North America?

Nobody has been diagnosed with GWS that didn't serve in the Gulf.

In contrast however, any individual who was diagnosed with GWS would automatically meet the criteria for a CFS diagnosis - which are given out like halloween candy.
 

Offline exothermic

  • Sr. Member
  • ****
  • Posts: 482
  • Thanked: 22 times
    • View Profile
Re: What is the Gulf War syndrome?
« Reply #18 on: 14/09/2016 10:09:23 »
Thus I believe this militarized program of stratospheric aerosol injection could be implicated in the pathology of the gulf war syndrome.

This is where you lose me..... completely.
 

Offline exothermic

  • Sr. Member
  • ****
  • Posts: 482
  • Thanked: 22 times
    • View Profile
Re: What is the Gulf War syndrome?
« Reply #19 on: 14/09/2016 11:58:06 »
"No published studies have shown that in vivo immune responses or resistance to infectious disease challenges were altered in JP-8-exposed people."

Nowhere is it implied that aerosolized jet fuel is a causative agent in the pathogenesis of GWI.

^  ^  ^  ^  ^  ^  ^  ^  ^  ^  ^  ^  ^  ^  ^  ^  ^  ^  ^  ^
 

The Naked Scientists Forum

Re: What is the Gulf War syndrome?
« Reply #19 on: 14/09/2016 11:58:06 »

 

SMF 2.0.10 | SMF © 2015, Simple Machines
SMFAds for Free Forums