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Chemistry / Is halogenation of alkynes with propylene glycol possible?
« on: 27/12/2023 20:02:27 »
Propylene glycol (PG) is a electrophilic solvent (Lewis base) found in most vaping liquids. Furthermore PG is a secondary alcohol (ether) containing a free hydrogen-bond, thus participating in nucleophilic attacks in presence of oxygen and a halogen (ie: fluoride), giving yield to fluorocarbons derivatives. Hence, ether-based fluoroalkylation seem likely to produce water-vapor and a enol tautomer with potentially toxic effects to human health....
Consequently, can PG be used as a Lewis solvent for producing fluorocarbons (fluoroalkynes) in presence of an halogen such as fluoride?
Thank you in advance,
smart
Consequently, can PG be used as a Lewis solvent for producing fluorocarbons (fluoroalkynes) in presence of an halogen such as fluoride?
Thank you in advance,
smart