[charli (OP)]

Jim has a touchy question:

"I was wondering if the peripheral nerves of people who use Braille change, matching their changes in their cortex?"

[Just thinking]

"I was wondering if the peripheral nerves of people who use Braille change, matching their changes in their cortex?"

I think the peripheral nerve will develop and become more sensitive in the fingertips but as for the cortex?

[Halc]

I was wondering if the peripheral nerves of people who use Braille change ?"

If anything, prolonged use (by an individual) might develop callouses which would somewhat reduce sensitivity.
If reading Braille was a task that benefited all people and proficiency at it increased your survival odds, then natural selection would tend to evolve more sensitive fingers over many generations, but it would not change any one individual, unlike the way that muscle usage tends to increase muscular capability of an individual.

matching their changes in their cortex

The cortex might be very useful in the initial acquisition of skills like reading, playing an instrument, or driving, but the changes that define proficiency in such tasks is primarily in the hippocampus, not the cortex. The cortex simply isn't fast enough.

[evan_au]

People who are born with a sensory disability (eg blindness) tend to rewire their brains so that the "traditional" task allocation in the brain is modified - for example, the visual cortex takes over some spatial processing of sound inputs.

As with any trained skill, the brain of a person reading Braille will get better at it over time, partly by rewiring the brain.
- This will probably involve a tie-in between sensory input (the fingers) and auditory/language processing areas; this link would be rather weak in most people.

The following article describes an early Optical Character Recognition system (OCR), which translated the written word into sounds (sequences of musical chords). That would have required considerable brain reorganisation. This was proposed as a competitor to Braille, but it never really took off.

Of course, these days, we can get our smartphones and computers to read any web page aloud...

See: https://spectrum.ieee.org/a-century-ago-the-optophone-allowed-blind-people-to-hear-the-printed-word