Naked Science Forum

Life Sciences => Physiology & Medicine => Topic started by: smart on 25/12/2015 22:39:18

Title: Can antipsychotics alter intrinsic brain activity?
Post by: smart on 25/12/2015 22:39:18
The functional differences between antipsychotics and psychedelics substances are important. Psychedelics substances like cannabis does not appear to alter intrinsic brain activity.

http://www.ncbi.nlm.nih.gov/pubmed/18591474
Title: Re: Can antipsychotics alter intrinsic brain activity?
Post by: smart on 02/02/2016 12:44:19
Atypical antipsychotics genotoxicity appears to alter intrinsic brain activity and lipid peroxidation in vivo: Cannabis appears as non-genotoxic substance and an antioxidant.

http://www.ncbi.nlm.nih.gov/pubmed/21937534

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010080/

Polyphenols/Vitamin C may have neuroprotective effects on lipid peroxidation induced by atypical antipsychotics.

http://www.ncbi.nlm.nih.gov/pubmed/19225991

 
Title: Re: Can antipsychotics alter intrinsic brain activity?
Post by: exothermic on 09/02/2016 04:07:19
"Polyphenols/Vitamin C may have neuroprotective effects on lipid peroxidation induced by atypical antipsychotics"  ncbi.nlm.nih.gov/pubmed/19225991

That citation is exclusive to en vitro research. Resveratrol would be literally annihilated in transit via extensive intestinal and/or hepatic glucuronidation/sulfation prior to reaching plasma, and I don't believe there's any conclusive data indicating that oral vitamin c can permeate the blood-brain barrier.

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Title: Re: Can antipsychotics alter intrinsic brain activity?
Post by: smart on 13/02/2016 11:15:53
Quote from: exothermic on 09/02/2016 04:07:19
That citation is exclusive to en vitro research. Resveratrol would be literally annihilated in transit via extensive intestinal and/or hepatic glucuronidation/sulfation prior to reaching plasma, and I don't believe there's any conclusive data indicating that oral vitamin c can permeate the blood-brain barrier.

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Vitamin C has been shown to cross the blood-brain barrier in the oxidized form, dehydroascorbic acid:

http://www.ncbi.nlm.nih.gov/pubmed/9389750

Title: Re: Can antipsychotics alter intrinsic brain activity?
Post by: exothermic on 13/02/2016 17:04:16
While I won't disagree that vitamin C is an effective compound to counter lipid peroxidation, I'm pretty sure intracerebral dehydroascorbic acid concentrations are tightly regulated however, the inclusion of the thiol-antioxidant NAC would be of significant importantance for a myriad of reasons - one of which being the abillity of GSH to reduce dehydroascorbic acid back to ascorbic acid.

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Title: Re: Can antipsychotics alter intrinsic brain activity?
Post by: smart on 18/02/2016 21:42:09
Dopamine D1 receptor-induced signaling through TrkB receptors in striatal neurons.

http://www.ncbi.nlm.nih.gov/pubmed/18381284