Naked Science Forum

Life Sciences => Physiology & Medicine => Topic started by: thedoc on 03/12/2016 16:23:01

Title: What's the mechanism of action of aspirin?
Post by: thedoc on 03/12/2016 16:23:01

@popupcamptrout asked the Naked Scientists:
   What's the MOA of aspirin? has it multiple targets? What does this say about robustness in genetic networks?
What do you think?

Title: Re: What's the mechanism of action of aspirin?
Post by: exothermic on 03/12/2016 19:44:23

Aspirin at 81mg/day reduces the risk of atherosclerotic coronary artery disease & stroke by reducing coronary vasoconstriction and enhancing coronary vasodilation.

Aspirin facilitates endothelial prostacyclin production & localized vasodilation via the blockade of platelet thromboxane a2 production.

The downregulation by aspirin of thromboxane-induced vasoconstriction is important in the context of the ischemic-mediated oxygen supply-and-demand imbalances and reduced blood flow observed in coronary artery disease.

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Title: Re: What's the mechanism of action of aspirin?
Post by: smart on 15/12/2016 10:23:31

Aspirin is considered toxic at doses greater than 150mg per kg of body mass.

https://en.wikipedia.org/wiki/Aspirin_poisoning