Naked Science Forum

Life Sciences => Plant Sciences, Zoology & Evolution => Topic started by: evan_au on 05/11/2015 18:02:35

Title: Could we engineer humans to reduce Type 2 Diabetes, metabolic syndrome and Gout?
Post by: evan_au on 05/11/2015 18:02:35
Most species of mammals have an enzyme in the liver called Uricase; it breaks down uric acid.

However, humans and most apes have a corrupted genetic pathway to synthesise Uricase. This leads to a buildup of Uric Acid in the bloodstream. This directly causes gout in some people, but has been implicated in the explosion of fatty liver, metabolic syndrome (http://en.wikipedia.org/wiki/Uric_acid#Metabolic_syndrome) and Type 2 diabetes in the worlds richest countries.

Could we restore the genetic pathway to produce Uricase, reducing the impact of these non-contagious diseases?

As both Uric Acid and Abscorbic Acid are both powerful antioxidants, Abscorbic acid synthesis  (http://www.thenakedscientists.com/forum/index.php?topic=61605.0)would probably need to be restored before restoring Uricase functionality.