[demografx]

Hello demografx !
When will the new information research grant (  Pois) ?
Patience to the limit ,At the forum except nicotinic acid did not hear anything new. Impression that we are going in circles is nothing new for me here Last Chance Dr. Komisaruk . Was at different doctors but they did not help me because they did not know the solution .

Hi Kima! Poiscenter.com is contractually working with Dr Komisaruk -- so that's where all info can be found. Best wishes to all for 2014![]

[zee80]

Hi,
I have read the articles linked below about depression and microglia cells:

newbielink:http://www.nature.com/mp/journal/vaop/ncurrent/full/mp2013155a.html [nonactive]
newbielink:http://neurosciencenews.com/neuropsychology-mechanism-underlying-depression-712/ [nonactive]

May be they show us a way to understand and influence the brain-associated part of POIS

In the experiment it was shown, that the decline of microglia cells (microglia described as representatives of the immune system of the brain )  due to stress leads to depression and that some neuroprotective substances prevent this effect. Furthermore substances that support the growth of these cells reversed the depression-like symptoms.

In connection with POIS I find the following points interesting:

• Most (or all?) symptoms of POIS show an immunological background/connex.
  The microglia system seems to be part of the brain immune system.

• The system links stress at immunological and mental level: This supports experiences that the remove of inflammatory sites (e.g. tonsils, wisdom teeth, hyposensibilisation(?)...), as well as mental training like meditation have been reported to help.
  

• there is some literature connecting microglia cells with the impairment of dopamine producing neurons, symptoms of POIS have some similarities with symptoms of dopamine deficiency

• The article shows that the usage of substances previous to stress protects against depression.
  This is somehow similar to the effect of nicotinic acid in context with POIS

Do some of us have experiences with substances listed in the article?
Previous to orgasm: The antibiotic Minocycline or interleukin-1 receptor antagonists
After Orgasm:  endotoxin(?), macrophage colony-stimulating factor or granulocyte-macrophage colony-stimulating factor.



Have a good new year 2014!

nze80

[MrVat7]

Zee80

Symptoms of POIS do match with this^ article.I agree to depression context in those links Though this may not be accurate reason of occurrence/cause of POIS.
I explain it as follows.
There is not much degree of stress during an orgasm. Now, decline of microglia cells takes some time and regular stress can cause depletion of microglia cells, leading to depression. A POISer starts feeling depression within hours of ejaculation, which can be said almost instantly. Also recover within a week or so. So if there were decline of microglia cells upto level that can cause depression, it would at least a months to be cured from depression. It is generally accepted by that there is vasoconstriction in POISers after an orgasm and as niacin is a vasodialator, it helps.

Tonsils, Wisdom tooth and the soft palate tend to get cooler as one breathes the air that passes by the nasal tract. Because of Vasoconstriction these regions do not get enough of warm blood, inflaming them. If there were no tonsils, no inflammation and no pain.

Poisers undergo depression (sometimes intense) for a week or so because of cerebral vasoconstriction, Brain gets lesser amount of oxygenated blood causing brain fog and sleepiness.

In short I would say that do not get confused between depression and POIS. Both are different. Pois induces depression. From which POISer recovers within a few days.

MrVat7

[Kima]

MrVat7
 
Your theory there is no evidence. Second month you write without proof theory, you are not a scientist that would invent the theory. We must work with doctors  you are not a Doctor. You want to prove theory need proof.This roundabout will never end so believe me if everything will continue.

[MrVat7]

Okay I see. You want a proof. Yes I will give you. Another thing, my last post was not about ssbt, Show me in the post if I said semen in bloodstream.

I said about vasoconstriction,kim . Which we all POISers are aware about, maybe zee80 was not aware about it. you see My explaination was about vasoconstriction and not about ssbt. I would post about ssbt only on request. Or when i prove it. Now You can chill man.
 
Also please note that I am just expressing my own views, and views about a topic differs from person to person. This forum is for discussion and sharing own thoughts and views so that something new can be found.

MrVat7

[demografx]

The purpose of the study is to observe reactions and structural changes that may be occurring in the brains of POIS sufferers -- changes which explain the severe cognitive impairments of POIS, and also potentially explain the general physical reactions as a whole (pain, headache, severe fatigue, as examples).

If brain reactions are found, this will lead to determining the cause of POiS -- but more importantly -- may well elucidate treatments that are available now-- to counteract these changes.

Demo, in Dr. Komisaruk's proposal did he outline how he intended to solve the part above that I bolded? Say the prefontal cortex is found to have reduced blood flow in pois subjects, how will he know from an MRI what causes that specific effect at the biochemical system level, in only certain people. Just curious if he provided more info in that respect.

I'm sure he did, acronym, but we need to wait for more information to come out as contractual details are implemented between NORD and BRK.

http://poiscenter.com/forums/index.php?PHPSESSID=6b75c287c5ffc02af698f3a68c1cb369&topic=1225.msg11312#msg11312

[MrVat7]

Had a wet dream yesterday and masturbated today morning, wondering why I am feeling totally normal (no cognitive dysfunction  ) .. I took niacin in morning, but still there are no symptoms of POIS. May be because I ejaculated after three weeks( but no symptoms?? ) . #Feeling like a miracle  8D   

[MrVat7]

#UPDATE

I have undergone Antisperm Antibody Test. Results are as follows.

Parameter                                               Result             Unit                 Reference interval
*Antisperm antibody serum                        61               U/ml                        <75

Hmm. This means my body has presence of ASA .

My discussion with pathologist.
Fertile males do not produce/have ASA. ASA is produced when there is incidence of semen meeting blood. 61 out of 75 means 81.1% result. Fairly high.


--> I am planning to get one more blood test for ASA. Stay tuned for the results .

MrVat7

[noone1234567]

Is everyone here fertile

[MrVat7]

Is everyone here fertile

Excluding few who have got some of their reproductive organs removed (i dont remember names ) . members here including me , are fertile.

I am curious noone, what is your logic behind asking this question ?

[Kima]

Hello everyone.


Here's another good news, another person is treated minerals 90% had no symptoms. People confirmed to me that they drank scheme Arles. Progress is slow, but it helps to fully recover health . Daniel recovered during the year .

Believe me it's true.

[MrVat7]

I have tried taking vitamins and minerals , they proved to help just a bit to me .. But they were not useful much. I dont know if it helps to others.

List of vitamins and minerals which I took :
- Whole of vitamin B family
-Zinc
-copper
-iron
-ginseng
-Vitamin A
-Vitamin D
-Acetyl l carnalite
-omega 3 fatty acid
-Vitamin C
-Folic Acid
-Biotin
-Inositol

 

[noone1234567]

Trying to link it to your antisperm antibody theory.  It seems that one of the by products is infertility if the numbers are high enough

[MrVat7]

People with infertility have high antisperm antibody count, The thing is my antisperm antibody count is high, still I am fertile. That may be a sort of proof ( there's more proof to be found though ) for SSBT .

Antisperm antibodies are created only when sperm enters blood. Small amount of these antibodies are produced during puberty , but I am having elevated concentration of antisperm antibodies. This does Imply Spill of Sperm in blood. Then and only then this level of antibody can be produced in my body .

MrVat7

[Maciej]

Hello everyone.


Here's another good news, another person is treated minerals 90% had no symptoms. People confirmed to me that they drank scheme Arles. Progress is slow, but it helps to fully recover health . Daniel recovered during the year .

Believe me it's true.

Hello Kima,
Could you explain what does "drank scheme" Arles means;)? 
And about these who recovered. Did they went by Gbolduev mineral plan or they just trusted their local labs with the hair analysis and mineral treatment?

[Kingkong]

People with infertility have high antisperm antibody count, The thing is my antisperm antibody count is high, still I am fertile. That may be a sort of proof ( there's more proof to be found though ) for SSBT .

Antisperm antibodies are created only when sperm enters blood. Small amount of these antibodies are produced during puberty , but I am having elevated concentration of antisperm antibodies. This does Imply Spill of Sperm in blood. Then and only then this level of antibody can be produced in my body .

MrVat7

Hi MrVat7, I'm 54, I have children and I have pois. I find very interesting the results of your ASA. I read the list of the vitamins that you tried. Except Biotin and Inositol, I tried all the other on your list  without any result. I tried flunarizin whit some good result but the side effects were very important. Fatigue was the most important side effect, I was sleeping 12 hours a day. Niacin gave some result. What kind of other test will you try for your ASA? When you had your blood test for ASA, how much time you did it after having an O?

[gcrisp]

Hi
I have had POIS since about 50.
What you experience is what I call PART of the symptoms of a classical migraine attack (not just a gross headache which most people refer to as migraine). I have had major migraine attacks for my whole life. But POIS only developed for me at about 50. One of the major parts of a migraine attack is the inability to think down past a single level of complexity. You can THINK at a single level and know what you want to say, but you cannot actually SAY the words in any coherent manner. You become grossly dyslexic. This state usually lasts up to several hours, and is often accompanied by nausea.
Just recently I have started on the Youngevity Blood/Sugar package, and fingers crossed, no POIS or MIGRAINE so far.
May be worth a try . PS. I have also stopped using statins (cholesterol reducers). Something is working. My wife says she might keep me.....

[alphaq]

Interesting question/observation - for those that have cognitive symptoms as the main symptoms of POIS, does the following ever occur to you during POIS? (if you don't know, try it)

- When you bend your body over or put your head upside down for a few seconds, do you feel extreme pressure in the head, like as if your head is about to explode?
- And right after that you stand back up and realize your face and eyes are abnormally bloodshot?

Why I ask this is, is because the mental symptoms of POIS could be caused by something blood flow circulation related to the head/brain. There are a few other members of this thread that have previously hypothesized cerebral vasoconstriction as a possible cause of the cognitive symptoms.

[vik1379]

- When you bend your body over or put your head upside down for a few seconds, do you feel extreme pressure in the head, like as if your head is about to explode?

I feel the same! I made MRT of my brain and nothing bad was find.

I feel little better when I make massage of my head and back in pois or I drink glass of wite wine.

[gcrisp]

Trying to find a common theme here.

 Is anybody on this thread who suffers from POIS:
1/ Using statin drugs for lowering of cholesterol, "Crestor", etc.?
2/ Practicing a low cholesterol diet, all polyunsaturated foods like margarine, and vegetable oils , no eggs, minimal red meat etc.

The BAD cholesterol is essential for brain maintenance and cell renewal.
Eat at least 4 eggs a day. Cut out carbohydrates and all polyunsaturated fat input.
This will NOT lead to obesity.

To quote Malcolm Kendrick, MD:
"The French consumed three times as much saturated fat as was consumed in Azerbaijan, and had one-eighth the rate of heart disease."
"Every single country in the top eight of saturated fat consumption had a lower rate of heart disease than every single country in the bottom eight of saturated fat consumption."
"And still we are told that a high saturated fat diet causes heart disease."
End quote