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Life Sciences => Physiology & Medicine => Topic started by: Petrochemicals on 26/03/2020 22:57:23

Title: How do different viral loads affect the virus propagation within the body ?"
Post by: Petrochemicals on 26/03/2020 22:57:23
If you don't understand the question don't answer as you know as much as me!
Title: Re: How does viral load propagate?
Post by: evan_au on 27/03/2020 10:16:01
See: https://en.wikipedia.org/wiki/Positive-sense_single-stranded_RNA_virus
https://en.wikipedia.org/wiki/Viral_replication
Title: Re: How does viral load propagate?
Post by: chris on 27/03/2020 17:33:06
I don't understand the question, and I know quite a bit about viruses!

Propagate means spread.
Viral load means the burden of detectable virus (usually measured in terms of a quantity of viral particles, or genome copies, in a given volume of a body fluid.

So you can see my problem: the question doesn't actually make sense.

What is it that you want to know?
Title: Re: How does viral load propagate?
Post by: Petrochemicals on 30/03/2020 21:35:44
I don't understand the question, and I know quite a bit about viruses!

Propagate means spread.
Viral load means the burden of detectable virus (usually measured in terms of a quantity of viral particles, or genome copies, in a given volume of a body fluid.

So you can see my problem: the question doesn't actually make sense.

What is it that you want to know?
To mulitiply and spread, to reproduce and grow, to thrive

https://dictionary.cambridge.org/dictionary/english/propagate

I suppose the question should be "How do different viral loads affect the virus propagation within the body ?"

Given viral load is confined to within the host organism, as by definition the ammount contained there in, propagation is confined to the spread within the host organism. The multiplication and spread of the initial viral load, as in the growth of virus cell numbers and how different viral loads are dealt with.

I was wondering as to why doctors and medical staff succumb so easily to covid  in Italy where 12 percent of victims are medical staff, which is scary for them. Is the body caught off guard without enough resources to combat it or is it just a simle case of inability to recognise the virus, or something completley different ? I had a bit of a look for info online line but its not forthcoming.
Title: Re: How do different viral loads affect the virus propagation within the body ?"
Post by: evan_au on 31/03/2020 10:00:59
Revised question title:
Quote from: Petrochemicals
How do different viral loads affect the virus propagation within the body ?"
It takes a few days to a few weeks to mount a targeted immune response to a new invader.

A virus particle infects one cell, multiplies there, and releases many "daughter" virus particles into the vicinity. These will cause local inflammation and cell death as fast-response general-purpose immune systems kick into gear.

If a doctor breathes in (say) a billion virus particles after treating many infected patients, they will probably start attacking many different parts of the lungs simultaneously. This means that inflammation and cell-death are occurring throughout the lungs.

That means a rapid loss of lung capacity - and the virus could cause major lung damage. That is a loss of critical time before the immune system can get started on its days to weeks process of building up a targeted immunity against this new pathogen.
See: https://en.wikipedia.org/wiki/Coronavirus#Release
Title: Re: How do different viral loads affect the virus propagation within the body ?"
Post by: Petrochemicals on 03/04/2020 23:01:41
Revised question title:
Quote from: Petrochemicals
How do different viral loads affect the virus propagation within the body ?"
It takes a few days to a few weeks to mount a targeted immune response to a new invader.

A virus particle infects one cell, multiplies there, and releases many "daughter" virus particles into the vicinity. These will cause local inflammation and cell death as fast-response general-purpose immune systems kick into gear.

If a doctor breathes in (say) a billion virus particles after treating many infected patients, they will probably start attacking many different parts of the lungs simultaneously. This means that inflammation and cell-death are occurring throughout the lungs.

That means a rapid loss of lung capacity - and the virus could cause major lung damage. That is a loss of critical time before the immune system can get started on its days to weeks process of building up a targeted immunity against this new pathogen.
See: https://en.wikipedia.org/wiki/Coronavirus#Release
Thank you. I suppose it is a bit unnatural to be hanging around sickness, like they say of anti terror police, whilst most run away from danger some run toward.

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