« on: 13/11/2017 02:08:19 »
I would like to experimentally increase my dopamine levels which may have been downregulated by the unwarranted use of dopamine antagonists for 5+ years. The primary side-effect I experiment from this forced treatment is the suppression of dopamined-mediated REM sleep.
I'll preface this with a cautionary note:
Tread lightly when altering dopamine synthesis. You just might end up making the problem worse.
Chronic dopamine precursor-administration ultimately depletes dopamine levels. When the dopamine levels drop low enough, the precursor then becomes ineffective and the side effects of dopamine depletion arise.
Exogenously-induced dopamine-depletion can occur when one chronically administered precursor [e.g. 5-HTP] dominates the synthesis of dopamine through competitive inhibition. This will ultimately alter the dopaminergic control of sleep-wake parameters - thus suppressing the SWS & REM stages of sleep.
Nontheless, Mucuna pruriens is extremely effective as it contains high concentrations of levodopa [which is a direct precursor of dopamine] however with prolonged use, I would suggest adding 5-HTP to counteract tyrosine-mediated serotonin-depletion, but it might be a better idea to just keep the experiment short & sweet.
Additionally, I would suggest adding epigallocatechin gallate (EGCG), as it will inhibit the peripheral clearance of dopamine by Catechol-O-methyl transferase (COMT), which in turn increases levodopa's entry into the brain and subsequent conversion to dopamine.
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