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It is my understanding that this is an alergic reaction to semen. If this is true, why would a woman have the reaction with no exposure to semen? Thanks for comments. Joe L. Ogan
hi all,here is a little info/update about my P.O.I.S. experienceI have been taking niacin tablets for 3 months now and I can say it really has minimized my P.O.I.S symptoms and I'm feeling like a newborn manthe only most important thing is that I really have to have a FLUSH, otherwise the 'nightmare' will still occurthis happened to me yesterday, when I took my standard 200mgsomehow my body didn't react to it (I think the reason was I didn't drink enough water) and I decided to take another extra 100mgstill nothing happened so I decided to get an 'O' (after 1 hour) because I did not want to take an overdose of niacin30 minutes later as I went to bed, my P.O.I.S. symptoms came back!after having a terrible night, without hardly any sleep, a burning feeling and a lot of toilet visits (I always drink a lot of water after my 'O'), I actually felt quite good todaythe 300mg niacin did kinda do its job, although it was after the 'O'so I recommend ALWAYS GET A FLUSH before 'O' and try to urinate afterwards as soon as possible to get a clean valve
There was an interesting paper in PNAS this week by Gregg Adams from the University of saskatchewan. He has been looking at semen constituents that can trigger ovulation when injected into certain species. Specifically, it's known that some animals are reflex ovulators, meaning that they only release an egg when they mate (koalas, camels, llamas and rabbits are examples). The Canadian team have found that this substance is a nerve growth factor called NGF, the normal role for which is to nourish nerve cells.But here is where things get interesting. Injecting NGF into llamas' muscles will make them ovulate. And it also works on mice, that are normally spontaneous ovulators, like us.So the team speculate that, once placed in the female genital tract, NGF present in semen can move, via the bloodstream, to the brain where it affect the hormones that control fertility. They speculate in the paper that, even though humans are not reflex ovulators, the fact that men still make the substance means that it could be making a contribution to human fertility (and infertility if the male is deficient or the female insensitive to the effect).One therefore wonders whether the release of NGF from the seminal glands during ejaculation means that it is absorbed into the male circulation too, and whether this might have onward physiological effects?http://www.pnas.org/content/early/2012/08/15/1206273109Chris
Quote from: chris on 26/08/2012 09:35:25There was an interesting paper in PNAS this week by Gregg Adams from the University of saskatchewan. He has been looking at semen constituents that can trigger ovulation when injected into certain species. Specifically, it's known that some animals are reflex ovulators, meaning that they only release an egg when they mate (koalas, camels, llamas and rabbits are examples). The Canadian team have found that this substance is a nerve growth factor called NGF, the normal role for which is to nourish nerve cells.But here is where things get interesting. Injecting NGF into llamas' muscles will make them ovulate. And it also works on mice, that are normally spontaneous ovulators, like us.So the team speculate that, once placed in the female genital tract, NGF present in semen can move, via the bloodstream, to the brain where it affect the hormones that control fertility. They speculate in the paper that, even though humans are not reflex ovulators, the fact that men still make the substance means that it could be making a contribution to human fertility (and infertility if the male is deficient or the female insensitive to the effect).One therefore wonders whether the release of NGF from the seminal glands during ejaculation means that it is absorbed into the male circulation too, and whether this might have onward physiological effects?http://www.pnas.org/content/early/2012/08/15/1206273109ChrisFascinating. Do you think it might be possible to lose too much NGF via semen or have a mutation? pro-NGF appears to cause nerve apostosis. A few of us have had MRI's and AFAIK no neurologist has seen lesions so our assumption has been that this is mostly neurochemical.
Quote from: kurtosis on 26/08/2012 13:19:54Quote from: chris on 26/08/2012 09:35:25There was an interesting paper in PNAS this week by Gregg Adams from the University of saskatchewan. He has been looking at semen constituents that can trigger ovulation when injected into certain species. Specifically, it's known that some animals are reflex ovulators, meaning that they only release an egg when they mate (koalas, camels, llamas and rabbits are examples). The Canadian team have found that this substance is a nerve growth factor called NGF, the normal role for which is to nourish nerve cells.But here is where things get interesting. Injecting NGF into llamas' muscles will make them ovulate. And it also works on mice, that are normally spontaneous ovulators, like us.So the team speculate that, once placed in the female genital tract, NGF present in semen can move, via the bloodstream, to the brain where it affect the hormones that control fertility. They speculate in the paper that, even though humans are not reflex ovulators, the fact that men still make the substance means that it could be making a contribution to human fertility (and infertility if the male is deficient or the female insensitive to the effect).One therefore wonders whether the release of NGF from the seminal glands during ejaculation means that it is absorbed into the male circulation too, and whether this might have onward physiological effects?http://www.pnas.org/content/early/2012/08/15/1206273109ChrisFascinating. Do you think it might be possible to lose too much NGF via semen or have a mutation? pro-NGF appears to cause nerve apostosis. A few of us have had MRI's and AFAIK no neurologist has seen lesions so our assumption has been that this is mostly neurochemical. I was thinking more about the possibility that the NGF, released during ejaculation, might enter the male circulation in some way and that this might cause a physiological effect in males too.
"The ELISA performed in serum obtained from men indicated that NGF concentration was 40.8 ± 10.8 pg/ml, whereas women showed statistically significant lower levels, that were influenced by the menstrual cycle."
Taken together, present data point out that serum NGF concentration is sex-related and indicate a possible role of sex steroids as modulators of NGF secretion in humans. Further, these results strongly suggest that NGF is secreted in the bloodstream from the pituitary gland, modulated by a DA-mediated mechanism
brain fog is become a part of my life...life was always like this but now after knowing that i am suffering thru something i am a lot stressed...
I am really impressed with the medical pioneering many here are doing. But at the same time, dr. Waldinger had a research paper that showed over 80% were positive at an intradermal allergy test. So in my humble opinion, over 80% should pursue desensitization. If slit doesn't work, try scit. Of course you could be the 20%. But be aware that there is also "evidence" that says testosterone and vitamines like b3 suppress allergy symptoms. And supplements can have side-effects, who wants so be on medication or supplements for life?
Quote from: CertainlyPOIS on 21/08/2012 02:59:20Quote from: Nightingale on 20/08/2012 22:09:43Quote from: Joe L. Ogan on 20/08/2012 00:56:55Is it possible that is is some sort of Psychological reaction? Do you have a background in psychology/psychiatry? If not, I really don't think this deserves an answer...Quote from: Joe L. Ogan on 20/08/2012 00:56:55The medical field does not appear to be aware of Post Orgasmic Illness Syndrome(POIS).Oh really? If they did, do you think we would be doing all that we are doing here on these forums???why did you respond so harshly when he asked so nicely, he is just a curious person.For the benefit of Joe L. Ogan, POIS sufferers can be very touchy about any suggestion that the disease is psychiatric in origin. The reason for this is quite obvious when you think about it. The natural response for doctors hearing about such an illness is to assume some psychosexual condition brought about by anxiety and stress related to sexual acts. Some of us have experienced severe cognitive symptoms which have rendered us unable to function including displacement, severe memory loss, inability to concentrate accompanied by headaches, pain behind the eyes etc. From what I've read most POIS sufferers have been referred to psychiatrists (or variations thereof) but, despite taking the range of meds prescribed, not a single POIS sufferer has been cured by treatment of an anxiety disorder. That's really important to understand. There are sufferers who have taken their prescribed medication for months or years while still suffering POIS symptoms. I can't speak for everybody but I do feel a bit let down by the greater medical community. Apart from NORD, people suffering from a rare condition are being treated like lunatics, malingerers or both. I myself have experienced this whereupon a psychiatrists attempted to find anxiety issues that weren't there over 2 sessions. Whenever I said I wasn't worried about something, he'd ask "are you sure?". The psychiatrist decided that I was simply suffering from an acute anxiety disorder and needed yet more medication. Eventually I got to see another shrink who decided I wasn't demonstrating any of the normal symptoms of an anxiety disorder and sent me to an allergist. This is proving fruitful and after several blood tests it's clear that, for whatever reason, my body is constantly fighting some allergy. This has left me with a very dim view of psychiatrists and the prescription of drugs with uncertain actions and severe interactions to cure illnesses that may or may not be in someone's head. You will find that view elsewhere on the forum as there are anecdotes about telling the psychiatrist / psychologist that whatever treatment isn't working and effectively being told that you / the problem is stubborn and needs more drugs. That's why questions, no matter how well intentioned, about psychosomatic origins for POIS are like red rags to bulls. Indeed far from generalised anxiety, the POIS sufferer seems solely anxious with what happens when they have an O but oddly remains optimistic of finding a cure. Personally, I'm not depressed. I've found ways to alleviate my symptoms but it's not "cured" and I do feel some frustration that a cause & cure haven't been identified. That's why we want to get a NORD research grant. Despite the condition, there's very little fighting or arguing on this and the other forum. Indeed, it seems that most of us have quantitative jobs like engineering and finance and just want to figure out a way past this as cognitive and memory problems are frustrating as are accompanying other symptoms which sometimes resemble hay fever. Things that have brought some relief include niacin supplementation (so long as there's a flush of prostaglandin from mast cells and we can feel it), vasodilators, testosterone supplementation, supplements that boost testosterone and anti-allergy medications such as non-steroidal anti-inflammatories and steroidal anti-infllammatories.So our working hypothesis is that POIS is at least partially caused by an allergy and that its cognitive symptoms may be caused by problems in neurotransmitter levels. That's where we are. It's been a long road getting there.
Quote from: Nightingale on 20/08/2012 22:09:43Quote from: Joe L. Ogan on 20/08/2012 00:56:55Is it possible that is is some sort of Psychological reaction? Do you have a background in psychology/psychiatry? If not, I really don't think this deserves an answer...Quote from: Joe L. Ogan on 20/08/2012 00:56:55The medical field does not appear to be aware of Post Orgasmic Illness Syndrome(POIS).Oh really? If they did, do you think we would be doing all that we are doing here on these forums???why did you respond so harshly when he asked so nicely, he is just a curious person.
Quote from: Joe L. Ogan on 20/08/2012 00:56:55Is it possible that is is some sort of Psychological reaction? Do you have a background in psychology/psychiatry? If not, I really don't think this deserves an answer...Quote from: Joe L. Ogan on 20/08/2012 00:56:55The medical field does not appear to be aware of Post Orgasmic Illness Syndrome(POIS).Oh really? If they did, do you think we would be doing all that we are doing here on these forums???
Is it possible that is is some sort of Psychological reaction?
The medical field does not appear to be aware of Post Orgasmic Illness Syndrome(POIS).
Quote from: kurtosis on 21/08/2012 10:13:37Quote from: CertainlyPOIS on 21/08/2012 02:59:20Quote from: Nightingale on 20/08/2012 22:09:43Quote from: Joe L. Ogan on 20/08/2012 00:56:55Is it possible that is is some sort of Psychological reaction? Do you have a background in psychology/psychiatry? If not, I really don't think this deserves an answer...Quote from: Joe L. Ogan on 20/08/2012 00:56:55The medical field does not appear to be aware of Post Orgasmic Illness Syndrome(POIS).Oh really? If they did, do you think we would be doing all that we are doing here on these forums???why did you respond so harshly when he asked so nicely, he is just a curious person.For the benefit of Joe L. Ogan, POIS sufferers can be very touchy about any suggestion that the disease is psychiatric in origin. The reason for this is quite obvious when you think about it. The natural response for doctors hearing about such an illness is to assume some psychosexual condition brought about by anxiety and stress related to sexual acts. Some of us have experienced severe cognitive symptoms which have rendered us unable to function including displacement, severe memory loss, inability to concentrate accompanied by headaches, pain behind the eyes etc. From what I've read most POIS sufferers have been referred to psychiatrists (or variations thereof) but, despite taking the range of meds prescribed, not a single POIS sufferer has been cured by treatment of an anxiety disorder. That's really important to understand. There are sufferers who have taken their prescribed medication for months or years while still suffering POIS symptoms. I can't speak for everybody but I do feel a bit let down by the greater medical community. Apart from NORD, people suffering from a rare condition are being treated like lunatics, malingerers or both. I myself have experienced this whereupon a psychiatrists attempted to find anxiety issues that weren't there over 2 sessions. Whenever I said I wasn't worried about something, he'd ask "are you sure?". The psychiatrist decided that I was simply suffering from an acute anxiety disorder and needed yet more medication. Eventually I got to see another shrink who decided I wasn't demonstrating any of the normal symptoms of an anxiety disorder and sent me to an allergist. This is proving fruitful and after several blood tests it's clear that, for whatever reason, my body is constantly fighting some allergy. This has left me with a very dim view of psychiatrists and the prescription of drugs with uncertain actions and severe interactions to cure illnesses that may or may not be in someone's head. You will find that view elsewhere on the forum as there are anecdotes about telling the psychiatrist / psychologist that whatever treatment isn't working and effectively being told that you / the problem is stubborn and needs more drugs. That's why questions, no matter how well intentioned, about psychosomatic origins for POIS are like red rags to bulls. ...Kurtosis,I was impressed by your willingness to look at "touchy" topics on this forum.When I discovered four years ago that I had POIS, which had decimated my relational life for forty years, I struggled with the solutions and found nothing offered on this site to be successful. When I contacted Waldinger, he assured me that abstinence would stop the problem. At that point I had a decision to make, to keep fighting to find a way to be actively sexual or to find a way to accept the only known solution and find ways to live happily without sex, and in ten days it will be three years since I've been sexual with myself or others. I have not had one trace of the symptoms that plagued me since I was thirteen.People say to abstinence " Well we still have nocturnal emissions", but is that really the activity that is causing the lion's share of the symptoms? No, it is not. And the problem starts much earlier than "post" orgasmic. Once again, the second time I contacted Waldinger he assured me that that was true, too. Discussion of this topic was warned not to be talked about, under the threat of banning from this site several years ago, so be careful, this is 'touchy' too. The point is there is a way to solve this problem. It may not be what I like, but I care about solving the problem...not if I like the way it's solved.
Quote from: CertainlyPOIS on 21/08/2012 02:59:20Quote from: Nightingale on 20/08/2012 22:09:43Quote from: Joe L. Ogan on 20/08/2012 00:56:55Is it possible that is is some sort of Psychological reaction? Do you have a background in psychology/psychiatry? If not, I really don't think this deserves an answer...Quote from: Joe L. Ogan on 20/08/2012 00:56:55The medical field does not appear to be aware of Post Orgasmic Illness Syndrome(POIS).Oh really? If they did, do you think we would be doing all that we are doing here on these forums???why did you respond so harshly when he asked so nicely, he is just a curious person.For the benefit of Joe L. Ogan, POIS sufferers can be very touchy about any suggestion that the disease is psychiatric in origin. The reason for this is quite obvious when you think about it. The natural response for doctors hearing about such an illness is to assume some psychosexual condition brought about by anxiety and stress related to sexual acts. Some of us have experienced severe cognitive symptoms which have rendered us unable to function including displacement, severe memory loss, inability to concentrate accompanied by headaches, pain behind the eyes etc. From what I've read most POIS sufferers have been referred to psychiatrists (or variations thereof) but, despite taking the range of meds prescribed, not a single POIS sufferer has been cured by treatment of an anxiety disorder. That's really important to understand. There are sufferers who have taken their prescribed medication for months or years while still suffering POIS symptoms. I can't speak for everybody but I do feel a bit let down by the greater medical community. Apart from NORD, people suffering from a rare condition are being treated like lunatics, malingerers or both. I myself have experienced this whereupon a psychiatrists attempted to find anxiety issues that weren't there over 2 sessions. Whenever I said I wasn't worried about something, he'd ask "are you sure?". The psychiatrist decided that I was simply suffering from an acute anxiety disorder and needed yet more medication. Eventually I got to see another shrink who decided I wasn't demonstrating any of the normal symptoms of an anxiety disorder and sent me to an allergist. This is proving fruitful and after several blood tests it's clear that, for whatever reason, my body is constantly fighting some allergy. This has left me with a very dim view of psychiatrists and the prescription of drugs with uncertain actions and severe interactions to cure illnesses that may or may not be in someone's head. You will find that view elsewhere on the forum as there are anecdotes about telling the psychiatrist / psychologist that whatever treatment isn't working and effectively being told that you / the problem is stubborn and needs more drugs. That's why questions, no matter how well intentioned, about psychosomatic origins for POIS are like red rags to bulls. ...
decimated by POIS
Kurtosis,I was impressed by your willingness to look at "touchy" topics on this forum.When I discovered four years ago that I had POIS, which had decimated my relational life for forty years, I struggled with the solutions and found nothing offered on this site to be successful. When I contacted Waldinger, he assured me that abstinence would stop the problem.
At that point I had a decision to make, to keep fighting to find a way to be actively sexual or to find a way to accept the only known solution and find ways to live happily without sex, and in ten days it will be three years since I've been sexual with myself or others. I have not had one trace of the symptoms that plagued me since I was thirteen.People say to abstinence " Well we still have nocturnal emissions", but is that really the activity that is causing the lion's share of the symptoms? No, it is not. And the problem starts much earlier than "post" orgasmic. Once again, the second time I contacted Waldinger he assured me that that was true, too. Discussion of this topic was warned not to be talked about, under the threat of banning from this site several years ago, so be careful, this is 'touchy' too.
And the problem starts much earlier than "post" orgasmic..... Discussion of this topic was warned not to be talked about, under the threat of banning from this site several years ago, so be careful, this is 'touchy' too.