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Plant Sciences, Zoology & Evolution / Re: Evolutionary DNA Leaps in Chromosome counts?
« on: 06/08/2022 01:42:49 »
Chromosomes can merge (reducing the count of chromosomes) or split (increasing the number of chromosomes).
- Recent research has found that use of CRISPR can chop up a chromosome, leaving a "spare" bit floating around in a cell nucleus
- Neither of these processes need be immediately fatal to a cell, since you still have the same number of genes
- The problem comes when the cell divides - does each "daughter" cell still have a full set of genes?
- And in the next generation of organism - do they still have a full set of genes?
The centromere is a structure in the center of each chromosome that plays a vital role in duplicating DNA into each daughter cell.
- A split-off portion of a chromosome may lack a centromere, inhibiting gene replication (or sometimes, a new centromere may appear)
- Two joined chromosomes may have two centromeres, which leads to chromosome breakage
- So most cases of chromosome splitting or joining are bad for the individual organism (often leading to cancer) and the descendents (who will suffer high rates of genetic disease and infertility with the parent species)
- But in rare cases, a descendent will receive two copies of the same mutation, allowing speciation
- Gene sequencing can identify cases where chromosomes have split or joined, since biologists can compare which genes occur on which chromosome.
See: https://en.wikipedia.org/wiki/Centromere
- So "progress" (new species) do not always come from splitting chromosomes (fission).
- New species can come from fusion, too.
https://www.mun.ca/biology/scarr/Human_Ape_chromosomes.htm
- Recent research has found that use of CRISPR can chop up a chromosome, leaving a "spare" bit floating around in a cell nucleus
- Neither of these processes need be immediately fatal to a cell, since you still have the same number of genes
- The problem comes when the cell divides - does each "daughter" cell still have a full set of genes?
- And in the next generation of organism - do they still have a full set of genes?
The centromere is a structure in the center of each chromosome that plays a vital role in duplicating DNA into each daughter cell.
- A split-off portion of a chromosome may lack a centromere, inhibiting gene replication (or sometimes, a new centromere may appear)
- Two joined chromosomes may have two centromeres, which leads to chromosome breakage
- So most cases of chromosome splitting or joining are bad for the individual organism (often leading to cancer) and the descendents (who will suffer high rates of genetic disease and infertility with the parent species)
- But in rare cases, a descendent will receive two copies of the same mutation, allowing speciation
- Gene sequencing can identify cases where chromosomes have split or joined, since biologists can compare which genes occur on which chromosome.
See: https://en.wikipedia.org/wiki/Centromere
Quote from: OP
The leap from 46 or 44 Chromosomes to a working group of 48 chromosomes in the new species to be GorillasThe human genome appears to be the result of the fusion of two chromosomes that remained separate in other primates (ie humans went from 48 to 46, while gorillas & chimpanzees remained at 48).
- So "progress" (new species) do not always come from splitting chromosomes (fission).
- New species can come from fusion, too.
https://www.mun.ca/biology/scarr/Human_Ape_chromosomes.htm
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