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Hey guys, i think i've found something. I know we have already too many theories, but this one makes a lot of sense:Today on the news they said they have discovered that prostaglandin D2 (PGD2) is a key factor in male baldness. One of my symptoms of Pois is that after having an O. i lose a lot of hair, and if i don't O's then my hair remains strong and i don't lose it. Then i went to wikipedia and learned that PGD2 is related to Asthma and inflammation. And you know what? Another symptom of Pois, at least for me, is that it makes my asthma and my breathing efficiency quite worse. But not only this. PGD2 is also related to the Niacin Flush. In fact, is what it causes it: "Research carried out in 1989[3] found that PGD2 is the primary mediator of vasodilation (the "niacin flush") after ingestion of niacin (nicotinic acid)."Maybe the Niacin Flush is helping us, because it uses the PGD2 (in a different way than an O.) before having the O., and then the O. is not so harmful. Does anyone know if exist a drug that inhibits PGD2?
Laropiprant is a selective antagonist of the prostaglandin D(2) receptor subtype 1 (DP1), which may mediate niacin-induced vasodilation.
About quercetin, I remember I said we need a trcuk of apples to suppress inflammation But I didn't understand your post. You want to counter PGE-2 mediators caused by niacin or supposed caused by Pois ?
Quote from: lauracostis on 23/03/2012 00:55:36Laropiprant is a selective antagonist of the prostaglandin D(2) receptor subtype 1 (DP1), which may mediate niacin-induced vasodilation.Thanks a lot lauracostis,So now we have 2 candidates that inhibit PGD2 release: Diclofenac* and Laropiprant. We may have a third one: Quercetin: http://www.ncbi.nlm.nih.gov/pubmed/18831918 and i've found 2 more: Luteolin and Aspirin (the last one is not so effective): http://www.ncbi.nlm.nih.gov/pubmed/18223672Of the 5 candidates, 3 are drugs an 2 are supps. I suppose the effective dose in the supps is much different than the effective dose in the drugs. In the study, they talk about 1000mg (1 kg)of quercetin or luteolin per human. That is a lot, and would be very expensive. I've also found this thread where they talk about it: http://www.hairlosstalk.com/interact/viewtopic.php?f=32&p=672064They say that Niacin and Laropiprant target PGD2 "DP1" receptor (both in an inverse way), and that a new drug called "Setipripant" is in trials, and it will block PGD2 "DP2" receptor (that is the hair loss one).But we are here because of Pois, not hair loss, so the "DP1" receptor (the Niacin one) may work well for us.On the other hand, if we want something to enhance or mimmick (and not inhibit) Niacin, we should look for something that releases PGD2, and 5-HT (Serotonin). In the above Pubmed links it clearly states that Niacin increases 5-HT levels. Maybe a good candidate would be "triptans"? I think recently someone said his doctor recommended triptans to him in relation to Pois. Please, if someone tries any drug or supplement always read the information leaflet before. P.S.: And sorry if the Post is a bit too technical talk!! * Mellivora already tried Diclofenac and it didn't work for him. Interestingly, Diclofenac was proposed by Dr.Goldmeier.
I know this text is a paste-copy from original Dr. Lin's text.
Hi Guys,I had to try new XN tablets two days before of different producer, because my favorite tablets are not shipped anymore to my drug store. I have taken in 300mg and no flush, but despite of this I had sex, I thought they will work, but they didn't and POIS started slowly this day. And I had terrible POIS yesterday. I have suffered the whole day and in the evening it was clear to me that POIS will continue today in its worst form... However in the evening yesterday I decided to try POIS-removal method by taking more tablets to have the flush and to have a sex after that. And guess what - it worked! I have clear mind today despite my expectations to have a worst 2nd day of POIS!!Victor
Quote from: Quasar on 23/03/2012 12:18:53Quote from: lauracostis on 23/03/2012 00:55:36Laropiprant is a selective antagonist of the prostaglandin D(2) receptor subtype 1 (DP1), which may mediate niacin-induced vasodilation.Thanks a lot lauracostis,So now we have 2 candidates that inhibit PGD2 release: Diclofenac* and Laropiprant. We may have a third one: Quercetin: http://www.ncbi.nlm.nih.gov/pubmed/18831918 and i've found 2 more: Luteolin and Aspirin (the last one is not so effective): http://www.ncbi.nlm.nih.gov/pubmed/18223672Of the 5 candidates, 3 are drugs an 2 are supps. I suppose the effective dose in the supps is much different than the effective dose in the drugs. In the study, they talk about 1000mg (1 kg)of quercetin or luteolin per human. That is a lot, and would be very expensive. I've also found this thread where they talk about it: http://www.hairlosstalk.com/interact/viewtopic.php?f=32&p=672064They say that Niacin and Laropiprant target PGD2 "DP1" receptor (both in an inverse way), and that a new drug called "Setipripant" is in trials, and it will block PGD2 "DP2" receptor (that is the hair loss one).But we are here because of Pois, not hair loss, so the "DP1" receptor (the Niacin one) may work well for us.On the other hand, if we want something to enhance or mimmick (and not inhibit) Niacin, we should look for something that releases PGD2, and 5-HT (Serotonin). In the above Pubmed links it clearly states that Niacin increases 5-HT levels. Maybe a good candidate would be "triptans"? I think recently someone said his doctor recommended triptans to him in relation to Pois. Please, if someone tries any drug or supplement always read the information leaflet before. P.S.: And sorry if the Post is a bit too technical talk!! * Mellivora already tried Diclofenac and it didn't work for him. Interestingly, Diclofenac was proposed by Dr.Goldmeier. I would try a PGD2 agonist first not a PGD2 antagonist, I would think about maybe focusing on the vasodialatory effect of PGD2 and not try to counter it. Anyways, NSAIDs are COX inhibitors, which are designed to block prostoglandins, so I am asuming that everyone on this sight has tried an over the counter (OTC) NSAID, which did not cure them.
Quote from: John21 on 17/06/2009 11:36:23I am still mystified that I have experienced no symptoms this time around. Racking my brain, here are some possible reasons: 1. Dietary change (previously stated)2. Recent Relora use (did it change something?)3. Recent exercise change: High adrenaline/ intense cardio workout once a week (singletrack mountain biking)4. Sleep change (I am doubtful that this could bring total relief)5. Unknown factorMaybe you are just in a good cycle. You're probably now less stressed, less tired, more relaxed,energized... And so you have suffisant "energy" (hormones/neurotransmitters...) to avoid symptoms after orgasm.
I am still mystified that I have experienced no symptoms this time around. Racking my brain, here are some possible reasons: 1. Dietary change (previously stated)2. Recent Relora use (did it change something?)3. Recent exercise change: High adrenaline/ intense cardio workout once a week (singletrack mountain biking)4. Sleep change (I am doubtful that this could bring total relief)5. Unknown factor
I just learned that human growth hormone (HGH) can be increased substancially by intense cardio, such as sprinting:http://www.readysetgofitness.com/newsletter/10_New%20Research%20shows%20how%20to%20increace%20HGH%20530%25.htmQuote from: B_Jim on 17/06/2009 19:47:35Quote from: John21 on 17/06/2009 11:36:23I am still mystified that I have experienced no symptoms this time around. Racking my brain, here are some possible reasons: 1. Dietary change (previously stated)2. Recent Relora use (did it change something?)3. Recent exercise change: High adrenaline/ intense cardio workout once a week (singletrack mountain biking)4. Sleep change (I am doubtful that this could bring total relief)5. Unknown factorMaybe you are just in a good cycle. You're probably now less stressed, less tired, more relaxed,energized... And so you have suffisant "energy" (hormones/neurotransmitters...) to avoid symptoms after orgasm.Thinking back to this post in 2009... I am wondering if the intense exercise might have manufactured HGH, which somehow prevented POIS. Maybe it is worthy of an experiment: the next time you and yours are getting romantic tell her you have to go for a quick run first.
As an idea about how to get more donations, I think we should send email to all members of poiscenter.com forum with the information about activity to gather pois research funds. I know that everyone hates bulk emails, but the reason for this email is special and very important and thats why it is reasonable to do this.What do you think?
Quote from: victor.kons on 21/03/2012 19:18:33As an idea about how to get more donations, I think we should send email to all members of poiscenter.com forum with the information about activity to gather pois research funds. I know that everyone hates bulk emails, but the reason for this email is special and very important and thats why it is reasonable to do this.What do you think?With luck I'll get a newsletter out this weekend. The mechanism is set up and we have a list, although it doesn't include the latest members. There are some 300+ names, plus those most recently added for the surveys.
@observercenter where can I buy this niacin? I hope I dont' appear foolish by asking can I get it in CVS? Also what kind should I try to obtain? One other question that I would like to ask is what is everyone's sex vs. masturbation ratio? I think there could be some relation between that and POIS. On the symptom side of things is it common to be lightsensitive and experience eye folaters from POIS? What about stretch marks on the back?