1

Chemistry / Re: Is halogenation of alkynes with propylene glycol possible?

« on: 28/02/2024 12:30:46 »

Hi.

    I'm also not finding many references to the anaesthetic properties of the compound    1,3 dichloro propan 2-ol.

     There almost certainly are some adverse effects from e-cigarette vaping but it's not clear that  PG  is the biggest concern.   The "flavourings" that are added are sometimes considered as big a risk as anything else.    However, as you ( @smart ) have indicated, there is a small concern about the production of new compounds created during the heating and vapourisation process that were not present in the original liquid.  PG may contribute to the production of these new compounds.

    Some information is here:   https://www.ncbi.nlm.nih.gov/books/NBK507184/
Their assessment of the risks of PG inhalation were quite low.

Best Wishes.

Dear Eternal Student...

Thank you for this update. Glycerol halogenation is likely to happen without the need of fluorine or any specific secondary alcohol/ether. Hydroxyl radicals can substitute themselves for a halogen tautomer in presence of propylene glycol acting as a eletrophilic reagent. I am deeply sorry for this unintended confusion about 1,3-DCP.

In contrast, the real problem seems to be with glycerol halogenation of propylene glycol which produces 1,3-DHA (please see link below). Lastly, please note that TEMPO was used as a reagent in the study for simulating free radical based synthesis of DHA, a glycerol derivative.

I hope this helps,
smart

Method and process is here: https://www.sciencedirect.com/science/article/abs/pii/S0040403906015401

2

Chemistry / Re: Is halogenation of alkynes with propylene glycol possible?

« on: 09/02/2024 12:44:05 »

Welcome Back @ smart!

Chemistry Section is mostly dead.
I see Hope now.

ps - Nice signature line.

Thanks @Zer0 .

Here is some more updates on this thread :

1. Halogenation by itself can induce mild anesthesia. The exact mecanism appears to be linked to the blockade of CNS neurotransmission.
2. In addition glycerol-mediated halogenation has been linked to specific liver effects and glycerol-mediated modulation of energy homeostasis in chronic e-cigarette users.(Lechasseur et al, 2023)

Thus, chronic e-cigarette vaping (aka glycerol halogenation) appears to be functionally equivalent to one-pot synthesis of DHA, as explained here:  https://www.sciencedirect.com/science/article/abs/pii/S0040403906015401

3

Guest Book / Re: Introduce yourself and say hi.

« on: 14/09/2018 07:52:15 »

Hi all,

My nickname is Rhodesdipt. Really nice to meet you all fellas! 

Welcome to forum, @rhodesdipt !

Enjoy your stay...

tk

4

Just Chat! / Re: Any doctors in the house?

« on: 06/08/2018 10:37:20 »

And don't worry bro, you will be fine... Your cyber friends got your back! 

tk

5

Physiology & Medicine / Re: Is sexual pleasure caused by evolutionary genetics?

« on: 30/07/2018 00:32:12 »

Survival of the reproductionists?

lol

Nice one @mrsmith2211!!

tk

6

Geek Speak / Re: Can you recommend a YouTube video downloader?

« on: 14/07/2018 21:02:10 »

youtube-dl...

7

Physiology & Medicine / Re: Is homosexuality in black communities controversial?

« on: 20/01/2018 16:05:42 »

You keep doing this.
You ask "Why is homosexuality in black communities controversial?" without first asking
"Why is homosexuality in black communities controversial?".
Have you any evidence of that conjecture?

Fair enough. I updated the title.

8

Just Chat! / Happy New Year!

« on: 31/12/2017 11:27:54 »

Dear friends,

I wish you all a happy new year! 

Let peace, love and happiness becomes the universal language of humanity.

Let science rule over the tyranny of ignorance.

Let the world rally up to protect our freedom to think apart.

Let defend humanity from global dictatorship and oppression.

Let protect our kids and future from violence and dangerous drugs.   

Let speak out and protest peacefully against injustice, poverty, and deceit.

Let demonstrate to our global leaders that humanity is strong and cannot become a commodity or purchased by the elites.

Finally, let 2018 become the year we celebrate the end of the dictatorship of ignorance!


Sincerely,

tk

9

Science Experiments / Re: Diacritech - E-publishing company

« on: 20/12/2017 16:43:56 »

This is spam, right?

10

Guest Book / Re: Is psychology considered as a field of science?

« on: 17/12/2017 19:20:51 »

it obvious the reason for not having a psychology thread. I think a  separate forum  for psychology is good , its obvious that only people who have psychology problems will be interested.

I think you're confusing psychiatric problems with conventional psychology. Psychology in general does not limit itself to mental disorders.

11

Just Chat! / Re: Using caution in our age of terrorism

« on: 28/11/2017 11:36:56 »

I believe I'll surely shoot that someone else, not sure if I would aim at his/her head or make it a point blank fatal shot.
But for sure, I'll shoot that person.

If you commit murder you go to jail for the rest of your life and lose everything in the process. I would not shoot that someone else, because i'm profoundly a pacific person. Note that I'm not opposed to the right to own weapons for self-defense only!
 

12

Physiology & Medicine / Re: How to convince my psychiatrist to stop antipsychotic treatments?

« on: 01/10/2017 09:29:35 »

There is some evidence that cannabis use may contribute to development of schizophrenia.

Directly from your link: "The authors found that cannabis use alone does not predict the transition to subsequent psychiatric illness."

~

Thanks for writing @exothermic...

13

Physiology & Medicine / Re: Is electroconvulsive therapy for schizophrenia a punitive treatment?

« on: 30/08/2017 10:26:45 »

exothermic, i would like to apologize to you for my stupid comment.

Take care

tkadm30

14

Just Chat! / Re: What is consciousness,bunch of experiences or what?

« on: 20/08/2017 23:12:58 »

Hi Nimmie,

1.Supposing I was cloned,would my clone have my consciousness,that is, would he know he is/was me or would he have another consciousness.

I really don't think human consciousness depends on the brain to exist. Therefore it is likely that your clone would have its own consciousness and memories. Reductionism fails to coherently explain the role of the brain in human consciousness.

2. Supposing I was hit with a big hammer and did not die but suffer from a serious amnesia loosing all of my memories. Now loosing my memories would include all my beliefs, how to put on my shoes, cloths or even how to read and write, meaning all my experiences gone.....does that mean i am no longer conscious of myself. Relating it to religion, lets say I was a christian and due to the amnesia I suffered, I do not even remember anything about my beliefs, how is God going to judge that?

If God exist, he should remember each of us independently of our current status.

Lastly, I believe strongly consciousness is the proof I have absolute free will.

I hope this helps.

15

Physiology & Medicine / Re: Does orgasm activates lymph nodes? If so, how?

« on: 19/08/2017 10:17:26 »

I discovered lately that orgasm activates lymph nodes, could this be the reason why some people aren't susceptible to flu(cold) for a long period compared to others?

Yes, sexual arousal and orgasm may stimulate the immune system and increase leukocytes (white blood cell) production. See: https://www.ncbi.nlm.nih.gov/pubmed/15316239

16

Just Chat! / Re: Is the emergence of terrorism activity a zombie-like invasion?

« on: 09/06/2017 10:18:34 »

And just to make it clear, in case anyone gets hold of the wrong end of the stick...

I am a pacifist who is against all types of violence and oppression.

Your replies are welcome and very informative.
Remember that being an independent investigator is a honorable distinction for anyone of us seeking to share
wisdom...

17

Physiology & Medicine / Re: Why does my brain choose to relive my worst nightmare over and over?

« on: 30/05/2017 00:48:37 »

I had a difficult time a number of years ago and since then I have had frequent nightmares about the event. The nightmares are so real that when I awake I am terrified and my head hurts! If I am affected badly by this particular nightmare why does my brain choose to re-run it over and aver again?

Reexperiencing a traumatic event into a recurrent nightmare is fairly common for PTSD patients. Lucid Dreaming Therapy (LDT) and medications may help for treating PTSD-associated nightmares.

See: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2919672/

I hope this helps.

18

Physiology & Medicine / Re: How does drinking water affect blood pressure?

« on: 16/05/2017 09:03:25 »

This topic has been discussed before.
See: https://www.thenakedscientists.com/forum/index.php?topic=6363.0

19

Geek Speak / Re: How to implement a trackback feature in my blog?

« on: 13/05/2017 15:01:43 »

What's your blog about and how do I access it?

Just click on the tiny earth-like icon next to my username and you will access it.

20

Physiology & Medicine / Re: Why Does A Forced Smile Make You Feel Better ?

« on: 14/04/2017 12:35:56 »

I don't like to be "forced" of doing anything. The forced smile mental conditioning is perhaps a non-verbal communication
method to seek approval.