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Life Sciences
Physiology & Medicine
Does hyperaldosteronism cause hypochloraemia or hyperchloraemia?
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Does hyperaldosteronism cause hypochloraemia or hyperchloraemia?
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thedy
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Does hyperaldosteronism cause hypochloraemia or hyperchloraemia?
«
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07/07/2018 18:15:11 »
Hi,
I have found in many articles both statements that is, hyperaldosteronism could cause hypochloremia or hyperchloremia,not in same time of course. Which one is true?
Thanks
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Last Edit: 09/07/2018 17:23:06 by
chris
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Re: Does hyperaldosteronism cause hypochloraemia or hyperchloraemia?
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08/07/2018 04:13:57 »
This introductory article suggests that the main negative effect on electrolytes is low levels of potassium?
Although sodium and magnesium levels are also affected.
See:
https://en.wikipedia.org/wiki/Hyperaldosteronism
...especially the references down the bottom
But if you have this condition, or know someone who does, the patient should follow the advice of a medical professional, not advice from forum members who have never seen the patient.
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Re: Does hyperaldosteronism cause hypochloraemia or hyperchloraemia?
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08/07/2018 10:53:52 »
It's possible that it may cause both condition.
The chloride levels are normally maintained within fairly tight limits- and that suggests some sort of feedback control.
If the hyperaldosteronism disrupts the "measurement" part of that feedback system then the chloride levels would be uncontrolled and could rise or fall depending on other factors.
Ask a doctor.
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thedy
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Re: Does hyperaldosteronism cause hypochloraemia or hyperchloraemia?
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11/07/2018 17:36:03 »
Thanks for answers. Fortunately, my problem is just pure curiosity. I am student and I have read many articles, physiology and pathophysiology books, medical forums and I have asked physicians, but nothing and no one gave me satisfactory answer. I have found in books explanations that show us aldosterone,better said hyperaldosteronism could cause hypochloremia but also found explanations show us hyperaldosteronism could cause hyperchloremia.
Does patient with Addison s disease should have hypochloremia or hyperchloremia rather? Hypochloremia due to low aldosterone and therefore low natremia and so low chloride level or second concept, which would explain hyperchloremia, that is low bicarbonates need to be compensated by negative charge to obey electroneutrality, that means chloride retention. Or like physicians says: ,,everything is relative" and in clinical practice I should expect both options (hypo/hyperchloremia) in patient with Addison disease and outcome level of chloride ions is influenced by other variables, like input and output of fluids and solutes, general condition of patient and so on. I asked this, because in many medical sources there are both concepts, which are quite contradictory I suppose.
And the same problem I have with for example Cushing disease. Hyper or hypochloremia?Which mechanism contributes to chloride ions level? Electroneutrality-HCO3/Cl exchange or Cl absorption with sodium?
I always thought, that for example hypoaldosteronism causes hyperchloremia,then opposite ( hyperaldosteronism) causes hypochloremia logically.But as I said I have found many figures and tables in articles and med books which show us,that for example hypochloremia can be laboratory output in hyperaldosteronism and hypoaldosteronism as well. And I can not see reasoning.
Thanks a lot for possible answers and thanks for recent answers as well.
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