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Topics - iko

Pages: [1]
1
Guest Book / Aaaaargh... my thread disappeared!!!
« on: 23/12/2011 20:31:17 »
I recently discovered that my hyperthread about vitaminD&Leukemia...
became INVISIBLE (to my PC I mean) after the recent graphic 'maquillage'
of the Science Forum.
Is it dead or is it just a temporary Vitamin D 'black out'?
Ikod

2
Plant Sciences, Zoology & Evolution / Plantibodies: Can plants make antibodies?
« on: 06/04/2008 15:18:46 »
Plantibodies: what are they?

Is it possible to make human proteins from plants?

Really and truely?  [:o]

3
Complementary Medicine / Helicobattle: "If you cannot win them..."
« on: 05/04/2008 16:18:01 »
Helicobacter eradication is a lost battle when proper antibiotic treatment is not affordable and sanitary conditions don't allow prevention of reinfection in a short period.

Alternative treatments may help minimizing long term damage:


A curcumin-based 1-week triple therapy for eradication of Helicobacter pylori infection: something to learn from failure?


Di Mario F, Cavallaro LG, Nouvenne A, Stefani N, Cavestro GM, Iori V, Maino M, Comparato G, Fanigliulo L, Morana E, Pilotto A, Martelli L, Martelli M, Leandro G, Franzč A.
Section of Gastroenterology, Department of Clinical Sciences, University of Parma, Italy. francesco.dimario@unipr.it

BACKGROUND: Curcumin is the principal element of turmeric powder extracted from the root of Curcuma longa. Studies on curcumin have demonstrated some anti-Helicobacter pylori activity as well as immunomodulating properties. N-acetylcysteine and lactoferrin with their respective mucolytic and antibacterial activities might also be effective in H. pylori eradication therapy.
AIM: To determine if a 7-day non-antibiotic therapy comprised of curcumin, lactoferrin, N-acetylcysteine, and pantoprazole was effective for eradication of H. pylori infection and reduction of gastric inflammation, assessed by serum pepsinogens and relief of symptoms.
SUBJECTS AND METHODS: Twenty-five consecutive H. pylori-positive patients (12 males, mean age 50 +/- 12 years, range 31-76) with functional dyspepsia were enrolled. Patients were administered for 7 days curcumin 30 mg b.i.d., bovine lactoferrin 100 mg b.i.d., N-acetylcysteine 600 mg b.i.d., and pantoprazole 20 mg b.i.d. H. pylori status and upper gastrointestinal symptoms were assessed by (13)C-urea breath test and a scale of upper gastrointestinal symptoms intensity (absent, mild, moderate, and severe), as well as a blood test for serum pepsinogens (sPGI, sPGII), gastrin-17 (G-17), and anti-H. pylori IgG (IgG-Hp) at baseline (T0) and after 2 months (T1).
RESULTS: Three of 25 patients (12%) were cured of H. pylori infection. A significant decrease in the overall severity of symptoms (T0: 6, interquartile range [IQR]: 4.5-8; T1: 2, IQR: 2-3; p < or = .001), and sPGII (T0: 16 microg/L, IQR: 13-22; T1: 10 microg/L, IQR: 8-16; p < or = .001) and sPGI (T0: 82 microg/L, IQR: 67-97; T1: 74 microg/L, IQR: 62-94; p = .02) levels were observed after 2 months of the treatment. IgG and G-17 values did not significantly decrease after 2 months.

CONCLUSIONS: This novel therapy was not effective for H. pylori eradication. However, despite the bacterium persistence, significant improvement of dyspeptic symptoms and reduction of serologic signs of gastric inflammation were observed after 2 months at the end of the 7-day treatment schedule.

Helicobacter. 2007 Jun;12(3):238-43.





WARNING! HYPERSPECIALIZED TOPIC

Anybody not familiar with the 'Helicobacter connections' should go through this enlighting path first:

http://nobelprize.org/nobel_prizes/medicine/laureates/2005/marshall-lecture.html
http://nobelprize.org/nobel_prizes/medicine/laureates/2005/warren-lecture.html

...plus all interviews and documentaries. "Googling" for Helicobacter pylori could be too messy.
 

4
Plant Sciences, Zoology & Evolution / Why didn't insects become as big as dinosaurs?
« on: 06/02/2008 21:22:38 »
           

Why little insects couldn't manage to become as big as dinosaurs and dominate this Planet?
What didn't work in the perfect mechanism of spontaneous mutation, natural selection and evolution?

ikoD   [8D]

5
Physiology & Medicine / What is Whipple's disease?
« on: 15/06/2007 22:49:38 »
Working in a laboratory, I see very few 'real patients'
and follow some cases through clinical reports from my
colleagues and friends.
Then I read med. literature and case reports, of course.
In the last few years Whipple's Disease (WD) has drawn
my attention for various reasons:

- Intriguing clinical presentations.
- technical difficulties in making diagnosis.
- cheap, easy and instantly accessible cure (when caught on time).
- defined as a 'very rare' disease, but underdiagnosed frequently.
- many cases reported from Europe (many in U.K., Germany and Switzerland?).
- first observed one century ago (1907), it is still a sort of 'mystery'.


"Earlier diagnosis leads to earlier treatment and hopefully the prevention of chronic disabling complications and needless mortality from this once uniformly fatal condition."    James DG and Lipman MC, 2002 (see below)



I open the discussion with simple bits and pieces plus whipple-pictures
Hope many of the NKSforum readers will partecipate in this open thread.
 


   
http://www.scienceimage.csiro.au/index.cfm?event=site.image.thumbnail&id=188&viewfile=f&divid=PP
http://www.sanger.ac.uk/Info/Press/gfx/030221_T_whipplei_300.jpg



Quote from: iko on 22/08/2007 22:55:37
Quote from: iko on 22/08/2007 22:05:55

I overstressed on purpose intriguing reports from medical literature to open the discussion on how to find a cheap and easy way to avoid these treatable ailments going undetected for months and years, with all the human suffering involved.


In a few words, modern PCR technology will eventually allow us -in the near future- to develop special inexpensive microchips to detect by one simple blood test most of the germs that we carry 'on board'.

An infectious disease will be diagnosed in seconds starting from the germ this time, not from patients' medical history, signs and symptoms.

Quite a little revolution in clinical medicine, but today we do already use other 'screening' tests.
Of course we'll need top notch sensitivity and the highest number of bugs searched through a single test, to make it reliable, easy and cheap.
Unfortunately, these days we see some of this magic hightech show used mostly in forensic medicine.

ikodnotes   [^]


      
http://images.the-scientist.com/content/figures/0890-3670-050411-44-1-1.jpg
http://www.five.tv/media/image/11970633.jpg





Quote from: iko on 15/06/2007 23:22:25
The Bug
What is it?
Where is it found?
How is it transmitted?
What diseases does it cause?
Who/what is at risk of infection?

click here for free full-text!
http://microbiology.mtsinai.on.ca/bug/TW/tw-bug.shtml 




6
Guest Book / The "Seany hurricane"
« on: 27/04/2007 11:29:12 »
Hi there,

April stats about the forum traffic are quite amazing...
Number of newbies a bit lower, but almost double posts!
Any suggestion?  [;)]

ikothesis


click here to spot the pilot:   http://file028a.bebo.com/1/large/2007/04/14/21/2083589797a4108042551b65708621l.jpg


Hawker Seany Hurricane Mk X, NX33TF


http://www.air-and-space.com/20040516%20Chino/Dsc_0526%20Hurricane%20Mk%20X%





http://express.howstuffworks.com/gif/hurricane-ivan.jpg

7
Physiology & Medicine / Green urine
« on: 21/04/2007 23:19:16 »
Time for a joke.
Actually a very short tale about experience in the medical profession.
You cannot find everything in textbooks, personal experience helps.


CASE 1
An anxious mother of a 4yr old boy phones
his young, recently specialized pediatrician:

"I'm worried for my son, doctor. He seems all
right but his pee is actually bright green!"

The young doctor reassures the lady, saying
that a urine analysis could be indicated if
this little problem persists in the next few
days.  Then he starts searching any possible
cause in handbooks and pathology texts getting
more and more confused between all the various
pigments and green substances...

CASE2
Same question to an old white-haired pediatrician.

He smiles on the phone, going on writing a recipe
for the little patient he just examined:
"There is no reason to worry, madam, your
kid had probably ...  "   [???]


Possible answers are welcome!   [;D]



http://www.farscapeweekly.com/weblog/uploaded_images/February%20011-776864.jpg

8
Complementary Medicine / Does garlic have medicinal effects?
« on: 13/04/2007 22:39:44 »
I decided to move some garlic notes
that ended up in the Guest Book of
General Discussion & FeedBack to a
proper place: here!

Hope the discussion and posting rate will
increase in the next few weeks.

http://upload.wikimedia.org/wikipedia/commons/thumb/2/22/Garlic.jpg/400px-Garlic.jpg




Why a specific medical interest in garlic?
Well, why not investigating   "Plant compounds that have evolved over millions of years as chemical defense agents against infection. Garlic has been used in medicine for centuries..."
When the initial enthusiasm in orthodox medicine is gradually replaced by a major concern for its limits and - in some particular cases - its unacceptable percentage of failure, even neglected popular remedies may sound promising.

I found the first medical report in 1980, about garlic in cryptococcal meningitis: 75% efficacy versus 50% with the standard anti-fungal treatment (1).  I had seen a pediatric case just a few months before, that ended tragically after standard therapy failure and I was obviously impressed.
Chinese doctors then told me that they also used intravenous preparations for septic patients, together with common antibiotics, in the so called 'fever regime' antibiotic cocktails.
They did not claim miracle results, but it seemed to help and didn't cost much.
Talking about unpretentiousness and wisdom in oriental Medicine.

We do not use garlic in our western Medicine: little interest, few studies and poor 'evidences'.
Who is going to invest in clinical research with an 'unpatentable', inexpensive, awfully smelly substance?
It would probably take just a bit of money but quite a lot of guts and a good sense of humour!
Not exactly what you encounter in academic Science.
Actually most of the work still has to be done, before any hypothetical clinical application.  We are surely late and we are probably missing an efficient and inexpensive 'old tool' in our hands.

ikod

1) Garlic in cryptococcal meningitis: a preliminary report of 21 cases.
   [No authors listed]   Chin Med J (Engl). 1980 Feb;93(2):123-6.



9
That CAN'T be true! / New booster hypersupplements
« on: 01/04/2007 17:01:07 »


http://www.taccuinistorici.it/fotoricette/584.jpg

Hello everybody!
What day is today?    [;D]

 [:D] [:D]

10
Physiology & Medicine / The Helicobacter connection
« on: 22/03/2007 21:47:08 »
Some friend enjoyed this page from 'New Theories', so I thought to resuscitate it into 'Physiol.& Med.' for the fun of our Newbies and medical students.
The discussion is open:
are there other forms of cancer switched on by 'innocent' infectious agents?


Quote
All cancers are fungus related" is a blanket statement that is just incorrect. Perhaps some cancers are caused by certain fungal infections I just don't know. I do know however that all of them are not.

Mjhavok

 Shortly, we should be careful not to generalize so much talking about cancer. We fortunately live in a new century and scientific research has done something about it. At least we should talk about different forms of tumors, leukemias and lymphomas. In some particular case scientists finally managed to find a cause and design effective and specific treatments (without toxicity, compared to chemotherapy).

A type of slow growing gastrointestinal lymphomas called MALTomas (Mucosa Associated Lymphoid Tissue) had been treated by standard chemotherapy (CHOP protocol...what a name for a chemo!) until the end of the last century.
There was no suggestion about the origin of this clonal expansion of lymphoid cells in the gut. So the following action had to be blind and toxic.

But in the middle of the '80s two smart researchers from Australia, Barry J. Marshall and J. Robin Warren (Nobel Prize 2005) started their battle: they tried to demonstrate that a common bacteria, Helicobacter pylori, was the major cause of gastroduodenal ulcers in humans.
A standard antibiotic treatment was able to eradicate the bacteria,  allowing the ulcers (wounds in the mucosa) to heal spontaneously.


http://www.rph.wa.gov.au/pics/nobel.jpg

They initially got veggies and bananas at medical meetings, nevertheless they went on collecting more and more evidence to prove the "infectious theory" of peptic ulcer.
It had to be tough. Medicine is highly conservative for various reasons, and for a long time infectious diseases had been strictly defined: one bacteria, one disease.  Helicobacter pylori is very common in humans...but just few of us develop ulcers.   That was just enough to keep stalling any bright theory for years.
Finally H.p. eradication became the standard treatment.
Now there is growing evidence that persistent Helicobacter infection and continuous release of toxic substances for years, could be one of the causes of stomach cancer.

"...tumors: wounds that never healed..."

"...leukemia&lymphoma: infections never resolved..."

Shortly after it was found that the majority of the patients with MALT lymphomas were carrying H.p. and that eradication therapy alone was able to induce a spontaneous regression of the tumors.
It was obviously too good to be true, so over the years some patients were found to be resistant to antibiotic treatment (2-3 weeks, no chemo!) and their lymphomas where identified as more advanced, with more chromosomal damage, unable to stop growing even when the bacterial stimuli were removed by eradication treatment.

Here we have a model for cancer treatment:

SPOT the cause (if there is any, but never stop searching), remove it as fast as you can. Some clone of cells will STOP proliferating and gradually disappear.
In advanced cases, most cells have been damaged so much and their DNA heavily deranged, that they cannot stop dividing (even in cell cultures).  Trying to block these resistant cells, scientists are now assemblying properly designed molecules, non-toxic "magic bullets" that should take advantage of the great differences at molecular level showed by some tumor cells (abnormal receptors, defective enzymes, etc.).  Time runs fast for everybody, patients and scientists.



ikod


H. pylori in a gastric pit


http://www.pathguy.com/lectures/nejm_h_pylori.gif

Robert M. Genta, M.D.
David Y. Graham, M.D.
Veterans Affairs Medical Center
Houston, TX 77030

N.Engl.J.Med. 1996;335:250 Jul 25, 1996.       Images in Clinical Medicine




 

 

11
Guest Book / Garlic
« on: 29/10/2006 19:51:21 »
Dear Sirs,
I did really appreciate your choice of garlic as the new symbol of Complementary Medicine.
May I suggest to adopt this perfect image for Physiology & Medicine, instead of those silly looking greyish tablets?
Sincerely yours,

Dr. Ikod
Cefalo o Muggine ( Mugil cephalus)

12
Complementary Medicine / Is Cod Liver Oil actually good for us?
« on: 12/08/2006 13:17:15 »


http://www.taccuinistorici.it/fotoricette/584.jpg

Hello everybody!
I'm Iko, cofactor and vitamin enthusiastic supporter
and well known cod liver oil maniac around here.
I opened this CLO topic to complement my previous
"Childhood leukemia" topic in Physiol.&Med.

http://www.thenakedscientists.com/forum/index.php?topic=4987.msg41687#msg41687

You are kindly invited to read and discuss both topics.
Enjoy

iko

Quote
It's about whether to strongly and officially recommend a nontoxic nutrient when data to prove its efficacy are still unconfirmed.
In the case of diseases of unknown cause and poor treatment results
...unsatisfactory results, or 'suboptimal' if you prefer.

It's Philosophy of Science and practical medicine altogether

ikod  [^]

 
   thanks to the >100000 viewers   (just unbelievable!)





I'll try to share with you some recent good & bad things about:

cod liver oil (CLO),
an obsolete remedy of the past for some,
number-one superfood for others.


Even if CLO contains large amounts of Vitamin A and D3, Omega-3 fatty acids, it MUST stay here in Complementary Medicine.

You do not need a doctor or a prescription to give a glass of orange juice or a teaspoon/caps of CLO to your kids every day.

Specific topics about Vit.A or D should go to Physiology and Medicine...but I'm sure that you won't mind if I attach some vitamin post here too.




If you asked this fool on the hill which is the most amazing report about Cod Liver Oil (CLO) in the recent past, he would not have any doubt:

Maternal supplementation with very-long-chain n-3 fatty acids during pregnancy
and lactation augments children's IQ at 4 years of age.


Helland IB, Smith L, Saarem K, Saugstad OD, Drevon CA.
Pediatrics. 2003 Jan;111(1):e39-44.

To read the abstract click down here:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Retrieve&dopt=AbstractPlus&list_uids=12509593&query_hl=6&itool=pubmed_docsum

Pediatrics 2003, Norwegian research, scientifically sound:

Children more clever at 4yrs
with one spoon of CLO per day
during pregnancy and lactation!



Fig. 1. Scores on the K-ABC for children whose mothers had taken cod liver oil (n = 48) or corn oil (n = 36) during pregnancy and lactation. Values for the different subtests are shown. MPCOMP, Mental Processing Composite; SEQPROC, Sequential Processing; SIMPROC, Simultaneous Processing; NONVERB, Nonverbal Abilities.


 
http://s-2000.com/hi-iq/images/hiqw1.gif
http://www.innovationcanada.ca/18/images/rose_8-z.jpg


Neat eh?
 
...when I've got this information my two sons had already grown up!
Some people could still make it with their children.
A good point to start a mini-review and/or discussion.


iko




"Il sole dona la vita, il sole se la riprende" M.U. Dianzani, 1975.

13
Physiology & Medicine / Vitamin D deficiency in Leukemia?
« on: 03/08/2006 23:18:12 »
Quote
Maternal Dietary Risk Factors in Childhood Acute Lymphoblastic Leukemia (United States)
Jensen CD, Block G, Buffler P, Ma X, Selvin S, Month S.

...
Abstract

Objective:   Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, and the second most common cause of mortality in children aged 1–14 years. Recent research has established that the disease can originate in utero, and thus maternal diet may be an important risk factor for ALL.

Cancer Causes Control. 2004 Aug;15(6):559-70.    http://www.springerlink.com/content/t87661x864l14368/fulltext.pdf


Is vitamin D deficiency in childhood leukemia an underestimated reality?
Could cod liver oil - the old remedy, a relic from the past - help in the
empirically arranged but clinically effective today's treatment protocols?

Regards,

Enrico Incarbone MD
(Lucky father of an ALL survivor)


ALL: Acute Lymphoblastic Leukemia (common type: 65-75% alive after 5 years)


Unable to evoke the interest of local colleagues, I am sending this message through the Web.

Quote
I meant to discuss about Evidence Based Medicine or Patient Oriented Decisions...

It's about whether to strongly and officially recommend a nontoxic nutrient when data to prove its efficacy are still unconfirmed.
In the case of a disease of unknown cause and poor treatment results (2/3)...unsatisfactory results, or 'suboptimal' if you prefer.

It's Philosophy of Science and practical medicine altogether

ikod  [^] 

                   thanks to the >100000 viewers!


To support this one I started a special
"Cod Liver Oil" topic in Complementary Medicine.

http://www.thenakedscientists.com/forum/index.php?topic=5065.0

You are kindly invited to read and discuss both topics.

iko




Key words:  nutrition leukemia diet cod liver oil vitamin

Parole chiave:  nutrizione dieta leucemia linfoblastica olio di fegato di merluzzo vitamine




Quote from: iko on 02/12/2007 00:01:00
Quote from: dqfry on 28/11/2007 17:14:36
I can't tell you how many times I've came back to this topic and read postings over and over. I still haven't read it all yet! I can only thank you for being here and for sharing your knowledge and thoughts.

"A little knowledge that acts is worth infinitely more than much knowledge that is idle."

Kahlil Gibran

Thank you dqfry!
This thread started with a question for young scientists and open-minded medical students*:

Quote

Is vitamin D deficiency in childhood leukaemia an underestimated reality?
Could cod liver oil - the old remedy, a relic from the past - help in the
empirically arranged but clinically effective today's treatment protocols?


The aim was to make some smart girl/boy cross "cod liver oil" and "leukemia" on PubMed database and find the old 1988 "Shanghai report".
Then we would have discussed the opportunity to give some "cod" to leukemic patients.
Your totally unexpected, dramatic, precious contribution fixed the limits of this issue, proving, at the same time, that our message is reachable by parents and patients.
They are -in the end- the real target of this topic.

ikod

*a young scientist!
                       

http://t2.gstatic.com/images?q=tbn:f_8eZbUquaFsEM:http://www.uwosh.edu/science_outreach/kid%20microscope.jpg
http://blog.cerbero.eu/wp-content/uploads/2007/09/message-in-a-bottle.jpg
http://annietv600.files.wordpress.com/2006/11/journal_reading.thumbnail.gif

"the Shanghai Report":  http://www3.interscience.wiley.com/cgi-bin/fulltext/112672783/PDFSTART



http://www.mc.vanderbilt.edu/reporter/reporter_jpgs/reporter_3.10.06_11.jpg

Dr. Xiao Ou Shu



Quote from: iko on 28/04/2008 21:51:47

We know from the 'Shanghai report' that daily doses of vitamins A and D (actually cod liver oil!) -taken for at least one year- could be able to reduce leukemia incidence to half or 1/3.
It's not much, but we (parents) should give it a chance and offer this protection to our sick children, to avert relapse risk.
 



Quote from: iko2006-2008

"Now every evening, everywhere in the world, some parent
is reminding one of the kids to take his 'cod'."

one parent's dream

Parents don't need to ask a doctor or get a prescription
before giving a glass of orange juice and/or
cod liver oil caps to their children,
either they are healthy or sick.


Good NEWS on D-vitamin!!!

Quote

Vitamin D insufficiency in the pediatric oncology population:
defining who is at risk and the need for standardized screening.

M. A. Helou, G. Massey, G. Francis, K. Godder, J. Laver
 
Abstract:
Background: Survivors of childhood cancer are at increased risk for osteoporosis. Contributing factors include direct effects of chemotherapy and radiation therapy on bone, secondary hormone deficiencies, and chronic illness. However, vitamin D insufficiency could be a major risk factor during and after cancer therapy. Vitamin D insufficiency is common in healthy school aged children (median 25-hydroxy vitamin D [25(OH)D] = 28 ng/mL, 55% <30 ng/mL, 5% < 10 ng/mL.) Based on this data, we hypothesize that vitamin D insufficiency would be common among children with cancer. If vitamin D insufficiency is prevalent, correction may contribute to better bone health and immune responses in children with cancer. Methods: We determined the serum levels of 25(OH)D, PTH, calcium, and phosphorus for 40 children with leukemia or lymphoma currently on therapy (group 1), 34 children with leukemia or lymphoma off therapy (group 2), 16 children with solid tumors currently on therapy (group 3), and 10 children with solid tumors off therapy (group 4.) Prevalence of 25(OH)D insufficiency ( <32 ng/mL) and severe deficiency (<10 ng/mL) was compared by Chi square test to the healthy reference population (established by Weng, et al.)
Results: For the majority of patients, calcium and phosphorus levels were within normal limits. Conclusions: Vitamin D insufficiency was very common in all groups, especially in children with solid tumors on therapy (Group 3.) 25(OH)D levels did improve off therapy, but for Group 2, still remained significantly less than normal reference population (p=0.0001.)

The data suggests that vitamin D status should be determined for all children at diagnosis of malignancy with a strong recommendation to consider vitamin D supplementation during treatment and follow up.

J Clin Oncol 26: 2008 (May 20 suppl; abstr 10023)



http://www.asco.org/ASCO/Abstracts+&+Virtual+Meeting/Abstracts?&vmview=abst_detail_view&confID=55&abstractID=35975

Something is finally "moving" on the clinical research side...
I hope(dream) that many parents -on the other side- are giving 'cod for more than one year'!

Quote

Unfortunately, if vitamin D is needed mainly, and too much vitamin A is either toxic or counteracting "D" wonderful effects (J.Cannell et al. Nov.2008), we would need a special cod liver oil formula:


a moderate amount of vitamin A, plenty of D-vitamin and lots of omega-3!


This probably WAS the original cod liver oil, before they started removing D-vitamin, erroneously thinking that it was too close to toxic amounts.     Two thousands I.U. per day of vitamin D3 were considered almost toxic for humans.
What a shame: we seem to have destroyed the original formula.






55220

14
Physiology & Medicine / New spicy treatment for malaria?
« on: 09/08/2006 12:47:31 »
Malaria remains a major global health concern.
New, inexpensive, and effective antimalarial agents are urgently needed
.


http://www.stemcellresearchfoundation.org/Research/ScientistMicroscopePhoto2.jpg


Hey! The old Ayurvedal/Chinese medicine is finally joining western orthodox medicine and is already giving very promising results, perhaps thanks to the immigrants from Asia to the USA/UK who are now leading big research labs.
Curcumin alone (Turmeric) is being extensively tested for various dreadful human diseases: hundreds of scientific reports and astonishing data...
Let's curry on!

iko

...these news come from the original Continent:
 
Curcumin-artemisinin combination therapy for malaria.

Nandakumar DN, Nagaraj VA, Vathsala PG, Rangarajan P, Padmanaban G.
Department of Biochemistry, Indian Institute of Science, Bangalore 560 012, India.

Artemisinin and curcumin show an additive interaction in killing Plasmodium falciparum in culture. In vivo, 3 oral doses of curcumin following a single injection of alpha,beta-arteether to Plasmodium berghei-infected mice are able to prevent recrudescence due to alpha,beta-arteether monotherapy and ensure almost 100% survival of the animals.

Antimicrob Agents Chemother. 2006 May;50(5):1859-60.
 



But this paper came first:

 
Curcumin for malaria therapy.

Reddy RC, Vatsala PG, Keshamouni VG, Padmanaban G, Rangarajan PN.
Dept.Int.Med.The Univ.Michigan Med.School, Ann Arbor, MI 48109-0360, USA.

Malaria remains a major global health concern. New, inexpensive, and effective antimalarial agents are urgently needed. Here we show that curcumin, a polyphenolic organic molecule derived from turmeric, inhibits chloroquine-resistant Plasmodium falciparum growth in culture in a dose dependent manner with an IC(50) of approximately 5 microM. Additionally, oral administration of curcumin to mice infected with malaria parasite (Plasmodium berghei) reduces blood parasitemia by 80-90% and enhances their survival significantly. Thus, curcumin may represent a novel treatment for malarial infection.

Biochem Biophys Res Commun. 2005 Jan 14;326(2):472-4.




http://www.sb-roscoff.fr/CyCell/Images/plasmodium1.jpg

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