Naked Science Forum
Life Sciences => Physiology & Medicine => COVID-19 => Topic started by: EvaH on 10/11/2020 14:26:30
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Harvey says:
I have protein S deficiency. I used to take Warfarin now I take Rivaroxaban. I have read that some patients with severe Covid 19 have been shown to have low levels of protein S and that those who were treated with an anti-coagulant fared better than those who did not. Today I heard that the new vaccine from Pfizer and others on trial work by modifying (attacking) the S protein of the Covid 19 virus. Do these 'S' proteins have anything to do with one another? Would having this deficiency mean I could not have the vaccine and am I, in any case, at greater risk?
Can you help?
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Zer0 further asks...
Do WE Not have a Single Covid19 Subject Matter Expert in the House?
P.S. - I Do Understand that real time data New data is being continuously generated on a daily basis, hence the term " Subject Matter Expert " might be void in relation to Covid19...still can Someone Please try to Answer this to the Best of their Abilities.
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protein S deficiency
This is a human protein that is involved in regulating the clotting process.
- There are a number of ways it could have low levels, including genetic causes or developing an auto-immune condition where antibodies attack it and disable it.
See: https://en.wikipedia.org/wiki/Protein_S_deficiency
new vaccine from Pfizer and others on trial work by modifying (attacking) the S protein of the Covid 19 virus.
These are independent uses of the letter "S".
- In this case, "S" stands for SARS-COV2 "Spike" protein: the part of the virus that allows it to enter cells.
- By disabling the S protein, the virus can't infect cells, and protects the vaccinated person against COVID-19 disease.
Do these 'S' proteins have anything to do with one another?
Recently, several countries put the Astra-Zeneca vaccine on hold, while trying to track down cases of cerebral (brain) thrombosis (clots).
- The conclusion was that the vaccine did not increase the rate of clotting in the general population (in fact, it reduced it, compared to non-vaccinated people).
- COVID-19 is known to cause abnormal clotting in some people
- The conclusion was that it is safer to vaccinate people than to let them catch COVID-19
Researchers are still monitoring a small group of people who may be more susceptible than the general population - mainly women under 55 who already have low platelet levels - a condition similar to heparin-induced thrombocytopenia
- A small study in preprint suggested that these events can cause headaches starting around 4 days after vaccination (by which time the symptoms on day 1 & 2 have dissipated). Treatment with an anticlotting agent is recommended (but not heparin or warfarin - others are available).
See: https://en.wikipedia.org/wiki/Heparin-induced_thrombocytopenia
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Do WE Not have a Single Covid19 Subject Matter Expert in the House?
We have experts in many fields, but those are their full time jobs, this is not.
Sometimes questions will get missed if our experts are busy, and this is a busy time for CV19 experts!
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Do WE Not have a Single Covid19 Subject Matter Expert in the House?
We have experts in many fields, but those are their full time jobs, this is not.
Sometimes questions will get missed if our experts are busy, and this is a busy time for CV19 experts!
@Colin2B
Thank You for providing a crystal clear explanation & Correcting me on the subject.
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& As Usual, Many Thanks to @evan_au for providing an elaborate explanation that is such detailed & Satisfactory.
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P.S. - pretty sure wherever Harvey is, Now would be Smiling!
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