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Chemistry / Re: quick question for bored chemist
« on: 03/06/2022 18:56:03 »
I'm not Bored chemist, but as a chemist, would be happy to offer some insight.
Any methylating agent with a sufficiently good leaving group will be able of damaging DNA, unless it is so good it reacts with water first or is not bioavailable (polymer supported methylating agents would be much harder to get into cell nuclei).
https://pubs.acs.org/doi/pdf/10.1021/ol025633s
http://www.arkat-usa.org/get-file/29478/
What are you hoping to methylate?
I would imagine it to be equally hazardous to one's dna.
Any methylating agent with a sufficiently good leaving group will be able of damaging DNA, unless it is so good it reacts with water first or is not bioavailable (polymer supported methylating agents would be much harder to get into cell nuclei).
https://pubs.acs.org/doi/pdf/10.1021/ol025633s
http://www.arkat-usa.org/get-file/29478/
diazomethanediazomethane is only useful as a methylating agent under acidic enough conditions to protonate the methyl group (for example, methylating carboxylic acids).
What are you hoping to methylate?