I'm glad to have found this post. I have a condition that definately involves the orgasm. Every since I started masturbating as a teenager I've been depressed and been a shy introvert. Before that I was an A student and very active in sports and had alot of friends. I just all of a sudden changed. As I've gotten older (I'm 32 now) I've developed alot of other problems like insomnia, social phobia, nervous ticks around people (like eye burning sensations or light sensitivity sensations in my eyes), nervous talking, neck muscle pain and stiffness, etc. The thing is I find that when I haven't had an orgasm for a while I seem to snap out of it and become happy again and socialable and most of those symptoms just vanish. When I mean for a while like not having an orgasm for about four of five days usually. I'll feel good and confident around people and usually sleep good. I also workout daily and jog so to keep me feeling good and improve my health and physique. However after a few days of no orgasms I become horny (naturally) and eventually start to play with myself until I come and the whole cycle starts over again. The good thing is I can usually have a single orgasm in about a four or five day stretch without much of the symptoms coming back. But often when I give in to masturbate once the horniness lingers on later in the day or night and I masturbate again a couple more times and until all the need is gone. I then develop all these symptons again and it takes days for me to recoup. I definately think that the orgasm combined with my brain chemistry can be proven detrimental in excess or even what is considered the norm in todays world and I really wish there were doctors that could diagnose and treat these problems. SSRI's have again and again proven unsuccesful with me. Seems like serotonin has nothing to do with my problem and only seem to make some of my symptons like insomnia and anxiety even worse.