« on: 28/02/2024 12:30:46 »
I'm also not finding many references to the anaesthetic properties of the compound 1,3 dichloro propan 2-ol.
There almost certainly are some adverse effects from e-cigarette vaping but it's not clear that PG is the biggest concern. The "flavourings" that are added are sometimes considered as big a risk as anything else. However, as you ( @smart ) have indicated, there is a small concern about the production of new compounds created during the heating and vapourisation process that were not present in the original liquid. PG may contribute to the production of these new compounds.
Some information is here: https://www.ncbi.nlm.nih.gov/books/NBK507184/
Their assessment of the risks of PG inhalation were quite low.
Dear Eternal Student...
Thank you for this update. Glycerol halogenation is likely to happen without the need of fluorine or any specific secondary alcohol/ether. Hydroxyl radicals can substitute themselves for a halogen tautomer in presence of propylene glycol acting as a eletrophilic reagent. I am deeply sorry for this unintended confusion about 1,3-DCP.
In contrast, the real problem seems to be with glycerol halogenation of propylene glycol which produces 1,3-DHA (please see link below). Lastly, please note that TEMPO was used as a reagent in the study for simulating free radical based synthesis of DHA, a glycerol derivative.
I hope this helps,
Method and process is here: https://www.sciencedirect.com/science/article/abs/pii/S0040403906015401
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