[leojoshrun (OP)]

I am surprised of the fact that people asks about Glucosamine and Chondroitin. Does these substance creates any side effects. How the medicines made by these two substances creates side effects.

Lets find it out!

Leo

[CliffordK]

I've been taking Glucosamine and Chondroitin off and on for a while. 

The primary reason is that on a couple of occasions, I've experienced mild swelling in the knees, as well as a mild back ache. 

It is difficult to judge the efficacy of the meds.  My knees have felt better, but I have also changed a few other aspects with my life.  Likewise, back pain can get better and worse depending on circumstances. 

I don't believe I've experienced any side effects that can be specifically attributed to glucosamine and chondroitin.  Mayo Clinic does list a number of potential side effects associated with glucosamine.

Some side effects such as a potential interaction with Diabetes is concerning.  Cataracts?

If many people take Glucosamine and Calcium supplements together, one might be tempted to associate constipation with the Glucosamine, when it may in fact be related to the Calcium, or even an interaction between the two.

This, of course, is also the risk of anecdotal inquiries.  To tease out slight differences, one must use large placebo controlled studies...  most of which show little or no benefit to glucosamine and chondroitin. 

What about chronic use?  A few months, years, decades?  Chronic use could be associated with potential benefits, but could also be associated with serious side-effects.

[Nika2003]

Hello everyone on the forum. I have problems with joints so when it comes to health supplements, glucosamine and chondroitin are some of the most popular. How popular are they? According to one estimate, about one in five patients take glucosamine, and one in 10 takes chondroitin.
They are advertised not only as an analgesic for the treatment of arthritis, but also as a means to prevent joint disease. However, a number of past studies have come to mixed conclusions - some small studies have shown that people felt better taking glucosamine and / or chondroitin, but at least many did not find any benefit. The fact is that these supplements that protect joint health or prevent arthritis are also weak ..
In general, glucosamine and chondroitin are considered safe. However, as with any treatment, there are potential risks. When I take a combination of glucosamine-chondroitin, there is diarrhea and abdominal pain. Other reported side effects include heartburn
drowsiness
headache
allergic reactions (especially if you have allergies to shellfish).
The study found that taking glucosamine may increase the risk of developing glaucoma, a condition that can threaten vision if left untreated. Chondroitin can act as a diluent of the blood, so it contains a warning of potential bleeding. Another problem is the interaction of drugs, a problem that can develop with any combination of drugs; consult your doctor or pharmacist before taking glucosamine and / or chondroitin. Many doctors warn patients that the FDA does not regulate additives such as glucosamine and chondroitin, so they can not contain the amounts indicated on the label, or they may contain contaminants.
Therefore, you must decide to take these medications and, of course, consult a doctor. All the best to you.

[AustinnEp]

Really good review, some people here will likely be interested. One Im surprised didnt get mentioned is -caryophyllene for its notable CB2 affinity. Ive never been interested in potent CB1 agonists but these other plants interest me. New to me is seeing anthocyanins as cannabinoid modulators