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Quasar, very interesting!
Quote from: Pharaoh on 11/08/2011 20:53:56Quote from: Counterpoints on 11/08/2011 15:28:38Quote from: Guthrie on 11/08/2011 01:33:32So, it may be that it is OK to take niacin regularly--that is, even if you build up tolerance so that it no longer causes a flush, it might still be able to prevent POIS because it is still 'using up' the histamine.I don't think POIS is about histamine though. Have antihistamines worked for anyone? Though perhaps it is also depleting other things involved in immune reactions..I was prescribed antihistamines (Allegra 180mg/day and Cyproheptadine 4 mg/day) and not only didn't they work, but I suffered from suicidal thoughts during POIS. I am convinced that the serotonin/dopamine levels are significantly suppressed causing the depression/brain fog/anxiety/anti-social symptoms we experience.About the serotonin/dopamine levels, did anyone get it tested in blood? I think so. It would be interesting to know serotonin and dopamine blood levels before an O., and after an O. And also, very important, to have a brain SPECT showing serotonin and dopamine levels. This is crucial. But it is difficult to justify to a doctor such an expensive technique...
Quote from: Counterpoints on 11/08/2011 15:28:38Quote from: Guthrie on 11/08/2011 01:33:32So, it may be that it is OK to take niacin regularly--that is, even if you build up tolerance so that it no longer causes a flush, it might still be able to prevent POIS because it is still 'using up' the histamine.I don't think POIS is about histamine though. Have antihistamines worked for anyone? Though perhaps it is also depleting other things involved in immune reactions..I was prescribed antihistamines (Allegra 180mg/day and Cyproheptadine 4 mg/day) and not only didn't they work, but I suffered from suicidal thoughts during POIS. I am convinced that the serotonin/dopamine levels are significantly suppressed causing the depression/brain fog/anxiety/anti-social symptoms we experience.
Quote from: Guthrie on 11/08/2011 01:33:32So, it may be that it is OK to take niacin regularly--that is, even if you build up tolerance so that it no longer causes a flush, it might still be able to prevent POIS because it is still 'using up' the histamine.I don't think POIS is about histamine though. Have antihistamines worked for anyone? Though perhaps it is also depleting other things involved in immune reactions..
So, it may be that it is OK to take niacin regularly--that is, even if you build up tolerance so that it no longer causes a flush, it might still be able to prevent POIS because it is still 'using up' the histamine.
Quote from: Vincent Marcus on 12/08/2011 00:17:35Quote from: demografx on 11/08/2011 22:30:22The welcome message contains important information that might be seen for the very first time, and may result in something great!IMHO, there's no reason to shorten the welcome message.I suppose I now agree with Demo for the reason that members familiar with the welcome message can simply scroll past it when they see it. It doesn't waste any time since it's not like you have to read the entire message each time you see it. Just takes maybe a second to scroll past it. But more importantly it provides new visitors all the info they need to know about the forum at a glance.The welcome message is an absolutely fantastic part of the community that has built up here. I speak as someone who spends most of my life in a mental fog in which I find navigating this thread completely overwhelming. The welcome post is a great summary and place to start for people who are like me -- and it should stay that way. On the other hand, it would be better if it were shorter, for the mere reason that it's pretty overwhelming as it is! Fewer links, for example to the Pyropeach PDF would make it easier to comprehend immediately (the PDF already has loads of other links and info). Try reading it from the perspective of someone who loses track of long sentences, paragraphs beyond 3 lines and skips beyond the post if he gets frustrated (it took me years to realise that this was happening to me)
Quote from: demografx on 11/08/2011 22:30:22The welcome message contains important information that might be seen for the very first time, and may result in something great!IMHO, there's no reason to shorten the welcome message.I suppose I now agree with Demo for the reason that members familiar with the welcome message can simply scroll past it when they see it. It doesn't waste any time since it's not like you have to read the entire message each time you see it. Just takes maybe a second to scroll past it. But more importantly it provides new visitors all the info they need to know about the forum at a glance.
The welcome message contains important information that might be seen for the very first time, and may result in something great!IMHO, there's no reason to shorten the welcome message.
Quote from: cornelius on 12/08/2011 15:03:46Quote from: Vincent Marcus on 12/08/2011 00:17:35Quote from: demografx on 11/08/2011 22:30:22The welcome message contains important information that might be seen for the very first time, and may result in something great!IMHO, there's no reason to shorten the welcome message.I suppose I now agree with Demo for the reason that members familiar with the welcome message can simply scroll past it when they see it. It doesn't waste any time since it's not like you have to read the entire message each time you see it. Just takes maybe a second to scroll past it. But more importantly it provides new visitors all the info they need to know about the forum at a glance.The welcome message is an absolutely fantastic part of the community that has built up here. I speak as someone who spends most of my life in a mental fog in which I find navigating this thread completely overwhelming. The welcome post is a great summary and place to start for people who are like me -- and it should stay that way. On the other hand, it would be better if it were shorter, for the mere reason that it's pretty overwhelming as it is! Fewer links, for example to the Pyropeach PDF would make it easier to comprehend immediately (the PDF already has loads of other links and info). Try reading it from the perspective of someone who loses track of long sentences, paragraphs beyond 3 lines and skips beyond the post if he gets frustrated (it took me years to realise that this was happening to me)With regard to the debate over the length of the welcome post, it's probably important to remember that even if the welcome post were shorter, the Naked Scientist thread would still feel pretty 'cluttered' and hard to follow -- simply because it is just one single thread, and lots of different topics get thrown around. No matter what the welcome message looks like (and we all might have different opinions about how it should look), this will still basically be the case.So, in terms of the specific issue of things being easier to follow, perhaps the focus should be on the nice, new, organized POIS Forum with lots of lovely divisions between different topics! And where is that nice, new, organized forum? Oh yes, right here: http://www.poiscenter.com/forums/index.php [nofollow]
And that forum seems cluttered too. Too many categories to look at when there's not enough users/traffic to fill it.
Quote from: apostate801 on 13/08/2011 05:19:47And that forum seems cluttered too. Too many categories to look at when there's not enough users/traffic to fill it. Yes, that's what I thought too.
For those of you who like the free flow, one thread feel, use: http://poiscenter.com/forums/index.php?action=unread
Hi guys. Checking in after a long absence. Have not had anything to contribute for along while, esp. since my medical knowledge is limited, but I have been reading the posts religiously. Very impressed with the ideas that have come up and with the overall quality of the discussions. Would like to bring up two issues. I have been one of longest sufferers on this forum. I am now 53 years old and have suffered from pois since I was 14. What I want to share with you can be good news or bad depending on your expectations, but over my almost 40 years of dealing with POIS it has gotten neither better nor worse, both in terms of intensity and duration. Brain fog, lethargy, aches, etc. all peaking at days two and three, just like they did in 1972. Second issue is support for the NORD fund. I am committing to donating $50 for every $1000 in the fund until we hit our initial target of around 34K (so far donated $100 ...). Seems to me that it takes only 20 of us to make a similar commitment, and we are there! Demo et al., thanks for the support and work in support of the good cause.Rob
I don't know if it was said but there are 4 types of Niacin : (french website/translation)-nicotinamide-hexaniacinate the inositol (also called inositol hexanicotinate or inositol nicotinate)-immediate-release niacin = the one we need creates 95% of the time a flush (often simply called niacin or fast-release niacin)-niacin extended-release (or slow)I guess I used (Nicobion) = nicotinamide which helped for 30% but no more, going to purchase the faster one definitively !
I am considering asking my doctor about Testosterone Replacement therapy [TRT] as well.
Could POIS be a severe form of migraine? Next time I may try the anti-sickness tablets for Migraine and see if helps with the awful nausea feelings I get. After four days my POIS has lifted - it is like entering the eye of a storm - all calm and clear, but a bit battered around the edges. It is amazing how it just fades out.