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Life Sciences => Physiology & Medicine => Topic started by: scientizscht on 05/03/2019 22:23:18

Title: Is there a list of the most abundant small molecules in human serum?
Post by: scientizscht on 05/03/2019 22:23:18: Is there a list of the most abundant small molecules in human serum?

Excluding large proteins and cells.
Title: Re: Is there a list of the most abundant small molecules in human serum?
Post by: chiralSPO on 06/03/2019 02:32:40: 30 seconds searching on wikipedia yields: https://en.wikipedia.org/wiki/Reference_ranges_for_blood_tests
Title: Re: Is there a list of the most abundant small molecules in human serum?
Post by: scientizscht on 06/03/2019 21:04:33: Again, most of my posts are well thought and researched, that a simple google search won't answer them.

I am pretty sure ATP, NADP are in adundance in blood, but your list doesnt have them.
Title: Re: Is there a list of the most abundant small molecules in human serum?
Post by: Bored chemist on 06/03/2019 21:30:59: Quote from: scientizscht on 06/03/2019 21:04:33
I am pretty sure ATP, NADP are in adundance in blood, but your list doesnt have them.
I'm pretty sure they are not.
"Plasma concentrations are three orders of magnitude lower than
within the erythrocytes, partly due to the rapid breakdown of ATP; only 1% of ATP is detectable in whole blood 40 s
after bolus injection."
From
https://watermark.silverchair.com/aei093.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAjgwggI0BgkqhkiG9w0BBwagggIlMIICIQIBADCCAhoGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMXIO_P4wRP2WuOO4YAgEQgIIB6yCDI2LsDbLjB_KYml-lBg1mte5qwECHRPGKQbaIXC3MOx82pNrmxz6MZbxBD_kOl99YaEQQiigTR-J7wquet8u-YFRBQGcuT2RqUiiuzPvs2TGMsCQvCfQyT-3YUJwoLGgTyGJPhEy26SRMbrNYbNg1gHZBpMGBlBydMfgN-GtIF7EPQm9W-aYNzPojZM0xKda0MRYkGsB2zN1dkHw1CWplmYTXK_htyNRbl_zghO4IfNOqGOKBe-AMDAblPSMwNUTqJkaGIqWIGxtdrWkQJfu8BSaLCQy-lMeY9bVrnoIKr6-5m745-IztDRO6QEL8PHTNm6DpKQn7oUqn5euVUqQFFc0QEmvuQWPznplrD8dVOJ0fy0ww7tQVH9ySsRm5k67uo5Pf9zwk4SBurlOKR8JRVH91aCGTnSjuf5cLU8tcWRu9LNI1BLqNE890S5Vddr3LmlHyZw3KPbVhKhDcC3C0M_neWZIdD8sySAtKfJRULHQ1cYwjix_ASgxAfMH9nr34yMlP1gAZfK9IQY10ouXqYRZ9EY6fzAr42-hH_BCxcbL0p6t7DyXMtdHqJeqs2dJLtbP4iErWTDzLXYjUFWhRruyG6etbq3AGDDohJS642q2iVfT0IomfdDEXLmCOJhU_4eUa4Gsxvwt7
Title: Re: Is there a list of the most abundant small molecules in human serum?
Post by: scientizscht on 06/03/2019 21:46:01: Well, you will be surprised that it's more than oxygen concentration in blood.
Title: Re: Is there a list of the most abundant small molecules in human serum?
Post by: chiralSPO on 06/03/2019 22:11:56: You may be surprised that oxygen isn't transported as free O₂ in the bloodstream. See: hemoglobin.
Title: Re: Is there a list of the most abundant small molecules in human serum?
Post by: Bored chemist on 07/03/2019 20:25:04: Quote from: scientizscht on 06/03/2019 21:04:33
Again, most of my posts are well thought and researched, that a simple google search won't answer them.
I beg to differ.
Googling "list "most abundant" "small molecules" " human serum""
gets you
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040193/
which cites this
http://www.serummetabolome.ca/
which, in turn leads you to this
http://www.serummetabolome.ca/metabolites

"The Serum Metabolome database is a freely available electronic database containing detailed information about 4651 small molecule metabolites found in human serum along with 10895 concentration values. The data tables may be sorted and searched by concentration values and ranges. "
Title: Re: Is there a list of the most abundant small molecules in human serum?
Post by: evan_au on 07/03/2019 22:03:33: When you make your "extensive list" of the most abundant small molecules in blood serum, most of the list entries will be H₂O.
Title: Re: Is there a list of the most abundant small molecules in human serum?
Post by: scientizscht on 08/03/2019 18:14:15: Quote from: Bored chemist on 07/03/2019 20:25:04
Quote from: scientizscht on 06/03/2019 21:04:33
Again, most of my posts are well thought and researched, that a simple google search won't answer them.
I beg to differ.
Googling "list "most abundant" "small molecules" " human serum""
gets you
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040193/
which cites this
http://www.serummetabolome.ca/
which, in turn leads you to this
http://www.serummetabolome.ca/metabolites

"The Serum Metabolome database is a freely available electronic database containing detailed information about 4651 small molecule metabolites found in human serum along with 10895 concentration values. The data tables may be sorted and searched by concentration values and ranges. "

How do you do the sorting per concentration?
Title: Re: Is there a list of the most abundant small molecules in human serum?
Post by: Bored chemist on 09/03/2019 01:29:05: Quote from: scientizscht on 08/03/2019 18:14:15
How do you do the sorting per concentration?
I don't.
If I wanted to , I'd stuff the relevant data into something like excel, and get that to sort it