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Plant Sciences, Zoology & Evolution / What is the effect of fusion of chromosome 2 in human nuclear cell?
« on: 17/11/2017 06:31:05 »
https://en.wikipedia.org/wiki/Chromosome_2_(human)
What will happen if chromosome 2 in human zygote splits at its vestigial telomere?
Or alternatively, what if 2 chromosomes in chimpanzee's zygote corresponding to human chromosome 2 somehow fuse?
Is there any research about this?
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Chromosome 2 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 2 is the second-largest human chromosome, spanning more than 242 million base pairs[5] (the building material of DNA) and representing almost 8% of the total DNA in human cells.
Chromosome 2 contains the HOXD homeobox gene cluster.
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All members of Hominidae except humans, Neanderthals, and Denisovans have 24 pairs of chromosomes.[7] Humans have only 23 pairs of chromosomes. Human chromosome 2 is a result of an end-to-end fusion of two ancestral chromosomes.[8][9]
The evidence for this includes:
The correspondence of chromosome 2 to two ape chromosomes. The closest human relative, the chimpanzee, has near-identical DNA sequences to human chromosome 2, but they are found in two separate chromosomes. The same is true of the more distant gorilla and orangutan.[10][11]
The presence of a vestigial centromere. Normally a chromosome has just one centromere, but in chromosome 2 there are remnants of a second centromere in the q21.3–q22.1 region.[12]
The presence of vestigial telomeres. These are normally found only at the ends of a chromosome, but in chromosome 2 there are additional telomere sequences in the q13 band, far from either end of the chromosome.[13]
According to researcher J. W. IJdo, "We conclude that the locus cloned in cosmids c8.1 and c29B is the relic of an ancient telomere-telomere fusion and marks the point at which two ancestral ape chromosomes fused to give rise to human chromosome 2."
What will happen if chromosome 2 in human zygote splits at its vestigial telomere?
Or alternatively, what if 2 chromosomes in chimpanzee's zygote corresponding to human chromosome 2 somehow fuse?
Is there any research about this?