0 Members and 1 Guest are viewing this topic.
Quote from: iko on 22/09/2007 15:56:39are there simple signs of asubclinical scurvy, availablein everyday clinical practice? No. (simple answer)
are there simple signs of asubclinical scurvy, availablein everyday clinical practice?
That means that the only observable effect of the disease will be this red colour. Does that mean that the red colour is a clinical sign of vitamin C deficiency and, if so, does it stop being sub- clinical.My point is that if you can see a sign or symptom then I don't think you have a sub-clinical condition any more. Once you can spot it I think it's clinical. I accept that analysis of the blood might reveal relatively low ascorbate levels well before there were observable symptoms.Hardlt an important point, just a matter of definition.
Subclinical scurvy should be low AA levels and no signs or symptoms.Assuming that red gums in a particular area could come much beforeand last for long, if the diet is just poor of vitamin C...Well...there is so much to be studied and confirmed still!
Hi VitaminC,we should have AAplasma levels in our laboratory routine.Actually this test is based on a cheap and simple chemical reaction estabilished in 1941.Its use has been sort of abandoned, due to lack of scorbutic patients...and interest.In my personal opinion, the area between florid scurvy and mild deficiency in concurrent diseases still needs further investigation.BTW did you know that Ascorbic acid in cerebral spinal fluid is 3-4 times more concentrated than in peripheral blood (plasma)?This cofactor should really do something important in our brain, to be 'pumped' so efficiently across the blood brain barrier! []ikod
Quote from: iko on 27/09/2007 18:53:35Hi VitaminC,we should have AAplasma levels in our laboratory routine.Actually this test is based on a cheap and simple chemical reaction estabilished in 1941.Its use has been sort of abandoned, due to lack of scorbutic patients...and interest.In my personal opinion, the area between florid scurvy and mild deficiency in concurrent diseases still needs further investigation.BTW did you know that Ascorbic acid in cerebral spinal fluid is 3-4 times more concentrated than in peripheral blood (plasma)?This cofactor should really do something important in our brain, to be 'pumped' so efficiently across the blood brain barrier! []ikodNow let's be serious for a while again...Does anybody know what is concentrated ascorbic acid doing in our brains?Even more concentrated in preterm babies and newborns?It is an old finding, still a mystery to me!ikod []
A flyer distributed in 1991 by the Linus Pauling Institute recommended daily doses of 6,000 to 18,000 mg of vitamin C, 400 to 1,600 IU of vitamin E, and 25,000 IU of vitamin A, plus various other vitamins and minerals. These dosages have no proven benefit and can cause troublesome side effects.Although Pauling's megavitamin claims lacked the evidence needed for acceptance by the scientific community, they have been accepted by large numbers of people who lack the scientific expertise to evaluate them. Thanks largely to Pauling's prestige, annual vitamin C sales in the United States have been in the hundreds of millions of dollars for many years. The physical damage to people he led astray cannot be measured. http://www.quackwatch.com/01QuackeryRelatedTopics/pauling.html
Linus Pauling was just plain wrong about vitamin C. Those repeating his claims abouyt it curing cancer are also wrong; if they are doing it to make a fast buck then they are frauds and should be prosecuted as such.It is true that people's fear of illness can lead to all sorts of odd behaviour (personally I think prayer is one of the oddest things it can produce but that's another topic). Taking big vitamin C pills when you have a cold is relatively harmless and the placebo effect may well make the overall effect on humanity beneficial.The oposite of this quackery is science; for example the science shows that adequate levels of vitamin C are required to prevent scurvy (science really shows this whether you like it or not).It also shows that excessive consumption is at best a waste of money, and in extreme cases harmful.That's a really good reason for singing the praises of science; not for talking nonsense about established biochemistry.
BTW did you know that Ascorbic acid in cerebral spinal fluid is 3-4 times more concentrated than in peripheral blood (plasma)?This cofactor should really do something important in our brain, to be 'pumped' so efficiently across the blood brain barrier! []
I start this topic with intention to explain that events that lead to establish the role between vitamin C and scurvy is “The Scurvy, the Vitamin C and the blasphemy” are littered with quackery and need to be re-examined.
Does anybody know what is concentrated ascorbic acid doing in our brains?Even more concentrated in preterm babies and newborns?It is an old finding, still a mystery to me!
Linus Pauling and vitamin C(The physical damage to people he (Linus Pauling) led astray cannot be measured.)
QuoteA flyer distributed in 1991 by the Linus Pauling Institute recommended daily doses of 6,000 to 18,000 mg of vitamin C, 400 to 1,600 IU of vitamin E, and 25,000 IU of vitamin A, plus various other vitamins and minerals. These dosages have no proven benefit and can cause troublesome side effects.
A flyer distributed in 1991 by the Linus Pauling Institute recommended daily doses of 6,000 to 18,000 mg of vitamin C, 400 to 1,600 IU of vitamin E, and 25,000 IU of vitamin A, plus various other vitamins and minerals. These dosages have no proven benefit and can cause troublesome side effects.
The fear from illnesses, diseases and premature death make humans highly vulnerable to quackery. Before any discussion about miracle healing property of vitamin C it is useful to confront with some fact about recently claims about healing property of vitamin C.
...Some ICU operators started giving i.v. vitamin C to severely burned patients.This recent experimental (poor sheep!) report actually supports previous clinical 'evidence':
http://lpi.oregonstate.edu/f-w03/images/Triplehelix.jpghttp://www.minerva.unito.it/Theatrum%20Chemicum/R1/paulingOld.jpgThere are ups and downs even for extremely smart scientists.Maybe Pauling went too high in the recent past...he will rise again.ikod [^]