Naked Science Forum
Life Sciences => Physiology & Medicine => Topic started by: smart on 13/06/2016 20:24:12
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What is the true purpose of atypical antipsychotics ? I'm on Abilify (Maintena) and each month I must get this stuff injected into my limb without noticing any side effects from this drug. Fortunately I don't pay anything to get this medication delivered into my brain. Why should this drug help with anything ? I read many horrible comments on the net about how people are suffering from this drug, but so far I'm unable to tell how this drug could induce negative side effects. I came to the conclusion that schizophrenia is a fake disorder pushed by psychiatry to medicate people based on pseudoscientific voodoo.
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They do something that's for sure. Typically, they bind neuronal receptors, such as serotonergic or dopaminergic, in your brain quite strongly. So strongly that the receptor protein does not unbind from the drug and this leads to various biological effects on the neuron such as decreased or increased activity and potentially cell death, or cell growth in some cases.
If you need a life change, antipsychotics will probably do that for you because they'll change your brain. More likely for the worse from what I gather, but there could be some good too.
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They do something that's for sure. Typically, they bind neuronal receptors, such as serotonergic or dopaminergic, in your brain quite strongly. So strongly that the receptor protein does not unbind from the drug and this leads to various biological effects on the neuron such as decreased or increased activity and potentially cell death, or cell growth in some cases.
If you need a life change, antipsychotics will probably do that for you because they'll change your brain. More likely for the worse from what I gather, but there could be some good too.
Thanks, Villi. I guess long-term antipsychotics use may induce dopamine hypersensitivity and mesolimbic neuronal damage. Thus, drug-induced schizophrenia is perhaps the result of antipsychotics binding to dopaminergic neurons.
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They do something that's for sure. Typically, they bind neuronal receptors, such as serotonergic or dopaminergic, in your brain quite strongly. So strongly that the receptor protein does not unbind from the drug and this leads to various biological effects on the neuron such as decreased or increased activity and potentially cell death, or cell growth in some cases.
If you need a life change, antipsychotics will probably do that for you because they'll change your brain. More likely for the worse from what I gather, but there could be some good too.
Thanks, Villi. I guess long-term antipsychotics use may induce dopamine hypersensitivity and mesolimbic neuronal damage. Thus, drug-induced schizophrenia is perhaps the result of antipsychotics binding to dopaminergic neurons.
Long-term use of antipsychotics has not been studied very well. The FDA clinical trials for approving these drugs are very short compared to how long some people have taken them. I wrote some papers for school about the long term side effects from a biological perspective, and these drugs do seem to shrink brains and change the chemistry. However, it's very important not to view this negatively because variations in brain size have many different effects from person to person, some beneficial. Another point, taking these drugs may change your chemistry (or you may be lucky and have powerful cyp genes, which metabolize these drugs and make them do nothing to you), but to stop taking them changes your chemistry too. The longer you take the Abilify, the more severe the withdrawal symptoms may be if you come off it. Injections are also a whole other ball game compared to pill form. So many more variables since there's more technology in them compared to pill form.
Again to stress this, there could be benefit. Just gotta try it out in little doses I think.
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Aripiprazole subgroup displayed significant increases in bilateral hippocampal volume compared with all other subgroups.
http://bjpo.rcpsych.org/content/bjporcpsych/2/2/139.full.pdf
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Poor insight and impaired judgement are a hallmark of psychiatric disorders ---all psychiatric disorders.
For example seeking pharmacological information from something like this forum might well be in indication that someone needs a conservatorship hearing.
The place to seek answers is the prescribing physician. These medications -second generation antipsychotics - are in use because they have relatively less side effects than first generation antipsychotics. But they should still be used after an evaluation by a board certified psychiatrist --- who knows his business.
Say what you will about antipsychotics, they have allowed hundreds of thousands of people to prolong their lives and avoid being locked up for the rest of their lives--- often in prison.
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There are no objective tests in psychiatry-no X-ray, laboratory, or exam finding that says definitively that someone does or does not have a mental disorder.” “It’s bull—. I mean, you just can’t define it.” — Allen Frances, Psychiatrist and former DSM-IV Task Force Chairman
http://www.cchrint.org/psychiatric-disorders/
Psychiatry will lock you up with antipsychotics dependence, no matter the mental disorder. My prescribing physician don't do biological testing to prove I have schizophrenia. The benefits of antipsychotics use are for psychiatrists and not for the patient I suppose. I guess my insight and judgement are not totally impaired by schizophrenia.
I rather have a fully detailed report of a biological test to prove i have a psychiatric disorder than a boat of pseudoscientific voodoo.
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Antipsychotic-induced insulin resistance and postprandial hormonal dysregulation independent of weight gain or psychiatric disease.
Diabetes. 2013 Sep;62(9):3232-40. doi: 10.2337/db13-0430. Epub 2013 Jul 8
Atypical antipsychotic (AAP) medications that have revolutionized the treatment of mental illness have become stigmatized by metabolic side effects, including obesity and diabetes. It remains controversial whether the defects are treatment induced or disease related. Although the mechanisms underlying these metabolic defects are not understood, it is assumed that the initiating pathophysiology is weight gain, secondary to centrally mediated increases in appetite. To determine if the AAPs have detrimental metabolic effects independent of weight gain or psychiatric disease, we administered olanzapine, aripiprazole, or placebo for 9 days to healthy subjects (n = 10, each group) under controlled in-patient conditions while maintaining activity levels. Prior to and after the interventions, we conducted a meal challenge and a euglycemic-hyperinsulinemic clamp to evaluate insulin sensitivity and glucose disposal. We found that olanzapine, an AAP highly associated with weight gain, causes significant elevations in postprandial insulin, glucagon-like peptide 1 (GLP-1), and glucagon coincident with insulin resistance compared with placebo. Aripiprazole, an AAP considered metabolically sparing, induces insulin resistance but has no effect on postprandial hormones. Importantly, the metabolic changes occur in the absence of weight gain, increases in food intake and hunger, or psychiatric disease, suggesting that AAPs exert direct effects on tissues independent of mechanisms regulating eating behavior.
http://www.ncbi.nlm.nih.gov/pubmed/23835329
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Q . Do atypical antipsychotics really work?
An objective-measure is the lower the incidence of suicide ...
http://www.prnewswire.com/news-releases/clozarilr-clozapine-reduces-the-rate-of-suicide-in-people-with-schizophrenia-according-to-study-in-the-journal-epidemiology-77774882.html (http://www.prnewswire.com/news-releases/clozarilr-clozapine-reduces-the-rate-of-suicide-in-people-with-schizophrenia-according-to-study-in-the-journal-epidemiology-77774882.html)
... I came to the conclusion that schizophrenia is a fake disorder pushed by psychiatry to medicate people based on pseudoscientific voodoo.
If schizophrenia is fictional, what is occurring with the homeless men claiming to be gods and/or the government is reading their thoughts (https://en.wikipedia.org/wiki/Thought_broadcasting) ... https://youtu.be/rCbf-pKtkhU?t=1m21s (https://youtu.be/rCbf-pKtkhU?t=1m22s)
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They work for people that really need them like a schizophrenic, however, psychiatrists prescribe them for the control of other mental illness Manic Depression, from which I suffer which made me much worse.
They make you into the "Living Dead" because they reduce one to a shuffling zombie and they have a terrible effect making it impossible to concentrate, get comfortable and give one an unbearable constant feeling of unease and restlessness.
Alan
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I rather have a fully detailed report of a biological test to prove i have a psychiatric disorder than a boat of pseudoscientific voodoo.
A biological test like a blood test?
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I rather have a fully detailed report of a biological test to prove i have a psychiatric disorder than a boat of pseudoscientific voodoo.
A biological test like a blood test?
Yes, a blood test would be a excellent diagnostic, assuming schizophrenia could be detected in the blood.
http://www.schizophrenia.com/sznews/archives/001395.html
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I rather have a fully detailed report of a biological test to prove i have a psychiatric disorder than a boat of pseudoscientific voodoo.
A biological test like a blood test?
Yes, a blood test would be a excellent diagnostic, assuming schizophrenia could be detected in the blood.
sznews/archives/001395.html
Thanks for the link.
I read about blood tests for bipolar and suicidal ideation but never came across this work for schizophrenia. This is a bit scary because more often than not, people are medicated straight away at any hints of psychiatric disorders. Therefore a blood test, and it's development, are skewed by the fact that there are almost no people with schizophrenia who are unmedicated to compare to with the 100% of people with schizophrenia who are/have been medicated.
I think you could detect "schizophrenia" in blood, but that is not really useful and is probably dangerous. Just my thoughts.
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Thanks for the link.
I read about blood tests for bipolar and suicidal ideation but never came across this work for schizophrenia. This is a bit scary because more often than not, people are medicated straight away at any hints of psychiatric disorders. Therefore a blood test, and it's development, are skewed by the fact that there are almost no people with schizophrenia who are unmedicated to compare to with the 100% of people with schizophrenia who are/have been medicated.
I think you could detect "schizophrenia" in blood, but that is not really useful and is probably dangerous. Just my thoughts.
Your thoughts are welcome. I don't mind sharing my experience with atypical antipsychotics and schizophrenia if that could help others. [;)]
I was forced to take antipsychotics medication because I believe chemtrails are real.
They think I'm delusional thinking that the government is spraying potentially harmful aerosols in the atmosphere. Anyways, I still believe chemtrails do exist, and that its a threat to public health.
http://www.thenakedscientists.com/forum/index.php?topic=65238.25
I think "schizophrenia" is a huge scam to alienate anyone who dares to challenge what society has accepted as normal life. I have never been aggressive towards anyone or commiting criminal offenses. I'm only interested in chemtrails because this activity seems highly illegal and we need to educate and inform the public about this.
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It is fairly uncommon for a patient who is sick enough to need antipsychotic medication to have enough insight to understand that he or she needs them. Personal anecdotal accounts don't carry much weight therefore.
A good way to check their efficacy is to ask the family members, who must live with the patient, whether they work or not.
Living with a person who suffers from a chronic mental disorder can be remarkably tedious --- and some times dangerous -- if and when they are cheeking their medications.
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It is fairly uncommon for a patient who is sick enough to need antipsychotic medication to have enough insight to understand that he or she needs them. Personal anecdotal accounts don't carry much weight therefore.
A good way to check their efficacy is to ask the family members, who must live with the patient, whether they work or not.
Living with a person who suffers from a chronic mental disorder can be remarkably tedious --- and some times dangerous -- if and when they are cheeking their medications.
You are partially wrong as a balanced manic depressive I fully comprehend the need of medication to keep me stable, however, during a severe manic state(Now long in the past thank God) I became delusional enough to think I was healed and had nothing wrong with me a threw all my medicine down the toilets and flushed it away.
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Schizophrenia is a really dumb disorder; I will never comprehend the need of medication for mental disorders.
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drug-induced schizophrenia
Long term cannabis use is thought to trigger schizophrenia in some individuals.
Maybe one drug is needed to counteract the side-effects of a previous drug?
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drug-induced schizophrenia
Long term cannabis use is thought to trigger schizophrenia in some individuals.
Maybe one drug is needed to counteract the side-effects of a previous drug?
Evan,
I figured this reasoning is partially wrong. Drug-induced schizophrenia is not causative of marijuana
administration.
Punishing someone by drugging him/her with antipsychotics is a likely cause of creating chemical imbalances in the brain by upregulating monoamine transporters. Marijuana use will not create symptoms of mental disorders
as it doesn't alter brain intrinsic activity.
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Marijuana use will not create symptoms of mental disorders as it doesn't alter brain intrinsic activity.
The soup of psychoactive chemicals in cannabis bind to a variety of endocannabinoid receptors in the brain, blood vessels, heart and gut.
This produces gross effects on brain activity which are visible in EEG patterns.
To me that sounds pretty impactful on intrinsic brain activity.
See: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234454/
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The soup of psychoactive chemicals in cannabis bind to a variety of endocannabinoid receptors in the brain, blood vessels, heart and gut.
This produces gross effects on brain activity which are visible in EEG patterns.
To me that sounds pretty impactful on intrinsic brain activity.
See: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234454/
Thanks for the link. Activation of endocannabinoid receptors (CB1, CB2) in the brain is a totally safe and natural method to neuromodulate stress. The definition of "intrinsic brain activity" is the biological mecanism of how the brain respond to stress. Antipsychotics alters intrinsic brain activity by normalizing dopamine and serotonin levels, which may increase oxidative stress. [1]
So it appears to me THC is very safe substance compared to atypical antipsychotics with selective affinities to dopamine D1 and D2 receptors..
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1) The ‘Holy Grail’ and ‘Poisoned Chalice’ Effects of Antipsychotics on Oxidative Stress in Schizophrenia: Can ‘Hormesis’ Explain this Paradox? http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3361856/
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The definition of "intrinsic brain activity" is the biological mecanism of how the brain respond to stress.
Where did you find that definition?
Intrinsic brain activity refers to the state of functional & spontaneous connectivity in the resting state.
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The definition of "intrinsic brain activity" is the biological mecanism of how the brain respond to stress.
Where did you find that definition?
Intrinsic brain activity refers to the state of functional & spontaneous connectivity in to the resting state.
There's no such thing as the "resting state". The brain is continuously attacked by oxidative stress and must defend itself from lipid peroxidation. Things like atypical antipsychotics generates oxidative stress and inflammation. Marijuana use is a anti-inflammatory and a anti-oxidant.
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There's no such thing as the "resting state"
Consistent resting-state networks across healthy subjects
Functional MRI (fMRI) can be applied to study the functional connectivity of the human brain. It has been suggested that fluctuations in the blood oxygenation level-dependent (BOLD) signal during rest reflect the neuronal baseline activity of the brain, representing the state of the human brain in the absence of goal-directed neuronal action and external input, and that these slow fluctuations correspond to functionally relevant resting-state networks. Several studies on resting fMRI have been conducted, reporting an apparent similarity between the identified patterns. The spatial consistency of these resting patterns, however, has not yet been evaluated and quantified. In this study, we apply a data analysis approach called tensor probabilistic independent component analysis to resting-state fMRI data to find coherencies that are consistent across subjects and sessions. We characterize and quantify the consistency of these effects by using a bootstrapping approach, and we estimate the BOLD amplitude modulation as well as the voxel-wise cross-subject variation. The analysis found 10 patterns with potential functional relevance, consisting of regions known to be involved in motor function, visual processing, executive functioning, auditory processing, memory, and the so-called default-mode network, each with BOLD signal changes up to 3%. In general, areas with a high mean percentage BOLD signal are consistent and show the least variation around the mean. These findings show that the baseline activity of the brain is consistent across subjects exhibiting significant temporal dynamics, with percentage BOLD signal change comparable with the signal changes found in task-related experiments.
J. S. Damoiseaux, S. A. R. B. Rombouts, F. Barkhof,‖ P. Scheltens, C. J. Stam, S. M. Smith, and C. F. Beckmann
Proc Natl Acad Sci U S A. 2006 Sep 12; 103(37): 13848–13853.
Published online 2006 Aug 31. doi: 10.1073/pnas.0601417103
PMCID: PMC1564249
Neuroscience
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The brain is continuously attacked by oxidative stress and must defend itself from lipid peroxidation.
ROS are a part of normal cellular metabolism and defence systems. The body's antioxidant defense system can readily detoxify intracerebral ROS-mediated lipid peroxidation & cellular damage. It's over accumulation of ROS which alters this dynamic balance between the antioxidant system and ROS, eventually leading to cellular injury in the form of lipid peroxidation, protein oxidation & DNA damage.
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Things like atypical antipsychotics generates oxidative stress and inflammation.
To what degree?
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Things like atypical antipsychotics generates oxidative stress and inflammation.
To what degree?
Atypical antipsychotics appears to increases metabolic inflammation and obesity. I gained 10lbs since I'm forced to take this treatment, three years ago.
Fortunately, aripiprazole doesn't seem to induce oxidative stress: http://www.ncbi.nlm.nih.gov/pubmed/18367441
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Marijuana use is a anti-inflammatory and a anti-oxidant.
Indeed. Great stuff.
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My former psychiatrist is assuming the risk of cannabis-induced psychosis is too strong to withdraw from antipsychotics. Since my delusional thoughts includes seeing visible and persistent plume of aerosol dumped from military aircrafts in the stratosphere, I really doubt this "medication" is helpful for anything. At least smoking pot relieves me from the stress of having no power on this clandestine activity. However, I'm feeling lucky that Abilify doesn't cause major extrapyramidal symptoms, but I don't see how this drug could force me to agree in the official narrative, or deter me to research the clinical effects of chemtrails on human health. So far, my experience with Abilify is positive (the drug seem to promote neurogenesis). Thus, cannabis is great stuff and the combination with Abilify appears a good one, but I will never quit smoking pot if the reason is to ignore science and believe in pseudo-scientific voodoo.
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It's very simple, all anti psychotics work to make a person tired because they're all tranquilizers, if that helps the person then yes anti-psychotics can treat symptoms caused by pathological alertness/wakefulness, they cannot cure hallucinations and they cannot change thoughts or opinions which are the root cause of dissonance, effective counselling is likely the best approach in all but the most hysterical individuals, problem is theres very few effective counselors and pharmaceuticals = big money
I'll also mention I've been diagnosed with nearly every major mental ailment known and i can confirm vocal hallucinations are very real and nearly impossible to distinguish from real voices, however, each time that ive gotten stuck in something like ocd, adhd, tourettes, pica, obesity, anorexia, sexual addiction, drug addiction, anxiety, depression, rage, manic euphoria, hallucinations, delusions, insomnia, I've gotten past it by researching the problem and practicing self discipline, I'm doing just fine so its very possible to adapt without the latest patented thousand dollar designer sleeping pill, but there's also times I do need a little help relaxing or falling asleep and while weed benzos alcohol and benadryl work better, anti psychotics can still get the job done
that being said i like to think the government is innocently/genuinely ignorant in their recklessness and if we're still breathing and riding the highs and lows in life were probably just as healthy as any other point in history. Ill also add that my current understanding of the vocal hallucinations is that my creator wanted me to gain something from their perspectives which i relentlessly take with a grain of salt, i believe we exist inside a simulation aka the matrix, and I'm linked up to the machine and being fed by the agents, but regardless of hallucinations everyone still makes their own decisions even if faced with the possibility of death.
If anyone reading this is struggling with vocal hallucinations the best thing you can do is not to fear them, avoid hostility, find common ground when necessary, be polite and eventually try to befriend them as much as possible without losing your sense of self or your morals