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There is an established procedure of taking immunoglobulins from one person (a plasma donation at the blood bank) and then injecting them into a patient to provide some immunity to conditions that the first person has recovered from.- However, the immunoglobulins only last a few weeks in the body before they are flushed from the body, and a new dose is needed.- With such a short protection, it won't achieve herd immunity- But it could be useful for treating a limited number of patients with a severe condition, who just need some extra help until their own immune system can get going- Assuming there is a large group of people who have already recovered from the virus (wait 3-4 weeks after symptoms disappear) and willing to go to the blood bank to do a plasma donationSee: https://en.wikipedia.org/wiki/Immunoglobulin_therapyTransferring live white blood cells into a sick patient is likely to create a war between the patient's immune system (fighting the "invading" cells), and the injected cells (fighting this "foreign" body they now find themselves inhabiting).- This could divert the patient's immune system from fighting the real invader: the virus.See: https://en.wikipedia.org/wiki/Transfusion-associated_graft-versus-host_diseaseBut maybe there are ways we could educate the patient's immune system about the virus- We normally do this through a vaccine (if we have time to develop one...)
Interesting question, but not do-able I'm afraid.
The way the immune system works is that specialised cells "present" components of viruses (or other infecting entities) to other cells in the immune system in the cellular equivalent of a shop window. Other passing immune cells (shoppers) browse and inspect what's on sale. Cells that happen to like (have an affinity for) what's in the window then get excited and a chemical (cytokine) "sales pitch" starts up between them and the cell displaying the thing they like. Ultimately, this leads to the excited cells starting to clonally expand by cell division. This leads to the production of a big population of cells that can make antibodies (of different types) that recognise the invader. It also, via a similar mechanism, leads to the production of cells that can kill off cells displaying features of the invader.
When scientists want to make therapeutic antibodies, they need to rely on the above process to find "the" cell from among the billions in the body that makes the right antibody.
That's why we still have to resort to injecting the thing into a rabbit to begin with. From that rabbit you home in on the cell you want, and from that cell you home in on the gene it's using to make the antibody you want. Then you're in business and can make huge amounts of the antibody in an artificial cell system.But no one is kidding themselves that we could make enough therapeutic antibody to protect the population from coronavirus infection. These antibodies are hard to make in sufficient bulk, so it's just not practical.
Could a VIP have a political prisoner who is well checked for viruses and of the correct blood group injected with COVID-19 and use his his blood plasma as treatment.It would not normally get past ethics committees but they don't cut much ice when its a matter of "national importence"
It has been tried in the Phillipines with T cells. The idea is - get the T cells to attack or recognise the virus, put them back in the person hoping they are taken to a secondary lymphoid site where they get the 'ere what you been up to treatment and specific T cells will be produced. I presume we would have heard if this works.
Not quite as I remeber it https://www.biospectrumasia.com/news/26/15833/singapore-explores-immunotherapy-for-covid-19-treatment.html
Would exposing memory B and T cells from a persons blood sample and gaining a response, then returning the educated blood sample to the person.
Quote from: opWould exposing memory B and T cells from a persons blood sample and gaining a response, then returning the educated blood sample to the person.I don't know how long the "education" phase would take, but I have been through plasmapheresis, which took about 45 minutes (plus setting up and clearing away the equipment, probably another 15 minutes).- There is a centrifuge to separate the red blood cells from the plasma- Maybe you don't need so much plasma as I gave, so maybe you only need to spend 5 minutes extracting the plasma?Using a disposable needle to inject a vaccine is cheaper and quicker than extracting white blood cells, educating them and then reinjecting them.- There is lots of non-reusable equipment when extracting blood plasma.See: https://en.wikipedia.org/wiki/Plasmapheresis
Jolly 2 "That's a horrible idea" of course but horrible things are done when its In "the national interest" ( like burning people to death with atom bombs) , on a more mundane level kidneys or even hearts are removed from "voluntaries" for transplant I was not offering my approval for such practices but just noting there is no limit to human cruelty when its a matter of national interest