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I just wrote a letter to Mary Roach, author of NY Times Top 10 Best Seller...Bonk: The Curious Coupling of Science and Sex, and speaker on "10 Things You Didn't Know About Orgasm" (her YouTube is at //www.youtube.com/watch?v=7jx0dTYUO5E[/b]I invited her to see our forum and asked her if she can make recommendations to us to further research our condition.
demographx good job, I love the way you are broadcasting it. I think it is time for you to check other hormones other than testerone, you might something else low. may be neurotransmitters.
welcome to the club, Botbot. What kind of irritability you have ?300.000 hopes for our future glory!!!
Quote from: CCconfucius on 30/05/2009 22:47:40demographx good job, I love the way you are broadcasting it. I think it is time for you to check other hormones other than testerone, you might something else low. may be neurotransmitters.Thanks a lot, CC! I did do a fairly extensive hormonal workup (http://www.thenakedscientists.com/forum/index.php?topic=6576.msg253144#msg253144), testosterone simply looked like the culprit, everything else was ok except prolactin, which puzzled the endo, led to an MRI of the brain (pituitary) but so far hasn't yielded any POIS suspicion (but who knows?). You might be right about neurotransmitters. Gee, I haven't even solved the high-prolactin problem! Finding a cure can be as exhausting as POIS itself! []Thanks again for the support, CC!ps - I thought I'd be "cured" today, but I still do have a bit of a POIS hangover. I hope it's the frequency lately and that the testosterone hasn't stopped working its magic!! Next round(s) will tell!
WHO UpdateThanks again, Pronobis, Martin and Counterpoints and everyone else who contributed! This email went to WHO today. Hopefully, we will get a reply.From: (demo personal email)To: WHO (World Health Organization)Sent: 5/30/2009 11:04:20 A.M. Pacific Daylight TimeSubj: Seeking help for our medical conditionDear WHO,We are writing to inform you about a serious new medical condition,....................
Great job Demo, I follow all you do here, even if I have nothing to add.
I will keep you in touch about my endocrinologist (?) rendez vous.
I think the severity of symptoms, and even the presence of symptoms at all, has a lot more to do with the specific ejaculation, than most seem willing to consider. As I've noted earlier, while symptomatic, an ejaculation can actually alleviate my symptoms, on occasion. Also, the severity of symptoms does seem to vary depending, I think, on the ejaculation.Others have mentioned this, (one sent me a PM about it), but I think most people have implicitly suggested this, in their posts. It's just that instead of thinking it has anything to do with the nature of the ejaculation, it's more "didn't get enough sleep, frequency has been too high recently, didn't eat enough, ate too much, didn't have this vitamin," etc. All of this is possible. But it's also quite possible that the physiological response to orgasm varies, for other more subtle reasons. Guthrie posted a fairly convincing reason for this. (e.g. one orgasm causes over-activation, which the body in turn, over-suppresses, allowing a subsequent orgasm to compensate for this, by causing normal "activation", which is followed by normal "suppression"). Another explanation could be that, for instance, there is a % chance a pituitary, adrenal, or other abnormality is activated. However, sometimes this activation won't occur.Even if something like testosterone helps, there could still be some underlying cause that is being activated to different degrees, based on a particular response to a particular ejaculation.
Quote from: Counterpoints on 31/05/2009 20:27:14I think the severity of symptoms, and even the presence of symptoms at all, has a lot more to do with the specific ejaculation, than most seem willing to consider. As I've noted earlier, while symptomatic, an ejaculation can actually alleviate my symptoms, on occasion. Also, the severity of symptoms does seem to vary depending, I think, on the ejaculation.Others have mentioned this, (one sent me a PM about it), but I think most people have implicitly suggested this, in their posts. It's just that instead of thinking it has anything to do with the nature of the ejaculation, it's more "didn't get enough sleep, frequency has been too high recently, didn't eat enough, ate too much, didn't have this vitamin," etc. All of this is possible. But it's also quite possible that the physiological response to orgasm varies, for other more subtle reasons. Guthrie posted a fairly convincing reason for this. (e.g. one orgasm causes over-activation, which the body in turn, over-suppresses, allowing a subsequent orgasm to compensate for this, by causing normal "activation", which is followed by normal "suppression"). Another explanation could be that, for instance, there is a % chance a pituitary, adrenal, or other abnormality is activated. However, sometimes this activation won't occur.Even if something like testosterone helps, there could still be some underlying cause that is being activated to different degrees, based on a particular response to a particular ejaculation.That's fascinating, CP! And very hopeful news! When you say varying POIS effects are due to "the specific ejaculation" I wonder if that could also include the sufferer's particular goings on at the time. For example, there was a very significant addition of stress for me this last time. Couldn't that trigger a "different physiological response" as you surmise?The added-stress factor has been playing on my mind a lot as a reason for my most disappointing POIS episode since starting treatment!And your theory that testosterone might not be the whole picture, I'm starting to believe is right...even though I don't want to believe it! []
CP, you may be interested to know that I did my last blood test (last week) symptomatic. So now I will have in-POIS and out-of-POIS comparisons.To everyone: CP convinced me and others here that in-POIS tests are the best way to start, followed by out-of-POIS comparison.