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Physiology & Medicine / Re: Is chronic Fatigue Syndrome treatable?

« on: 25/05/2021 11:46:05 »

Intracellular pathogens, including many associated with ME/CFS, drive microbiome dysbiosis by directly interfering with human transcription, translation, and DNA repair processes. Molecular mimicry between host and pathogen proteins/metabolites further complicates this interference. Other human pathogens disable mitochondria or dysregulate host nervous system signaling. Antibodies and/or clonal T cells identified in patients with ME/CFS are likely activated in response to these persistent microbiome pathogens.

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in the Era of the Human Microbiome: Persistent Pathogens Drive Chronic Symptoms by Interfering With Host Metabolism, Gene Expression, and Immunity. Front. Pediatr., 04 December 2018

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Physiology & Medicine / Re: Is chronic Fatigue Syndrome treatable?

« on: 25/05/2021 11:44:50 »

CFS is merely a broad term used to categorize a wide-ranging group of symptoms with multifactorial etiologies between patients.

Despite the fact that the clinical diagnosis of "CFS" will always be there for the physician who can't [or won't] give their patients any more answers.... "CFS" remains factitious because the etiology of the symptoms in any of these cases can be traced to an underlying pathology.

The pathomechanisms of ME/CFS are still unknown, and there are no standardized biological markers or tests for diagnostics; therefore, even the existence of this medical diagnosis has been questioned for long time [10].

The pathogenesis of ME/CFS is likely multi-factorial and various microbial and viral infections are considered to be the possible trigger factors of ME/CFS. The illness has been frequently accompanied with various viral infections and studies have been conducted on association of ME/CFS with Epstein-Barr virus (EBV) [17, 18], cytomegalovirus (CMV) [19], human herpes virus (HHV) 6, HHV-7, HHV-8 [20,21,22], human parvovirus B19 (B19V), enteroviruses [23], lentivirus [24] and bacteria as mycoplasma [25], Lyme disease causing borrelia, Q fever causing Coxiella burnetii [26] and other pathogens.

Chronic viral infections in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). Santa Rasa et al. J Transl Med. 2018.

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Physiology & Medicine / Re: Is chronic Fatigue Syndrome treatable?

« on: 23/05/2021 11:23:52 »

BMJ 2006;333:575
Post-infective and chronic fatigue syndromes precipitated by viral and non-viral pathogens: prospective cohort study

PFS --> Post-infective Fatigue Syndrome would be a more appropriate name for "CFS".... one where there is actually a defined etiology of the patient's symptoms. Again, whether it be viral, bacterial, immunological, ect.... eradicate the underlying pathology.... goodbye CFS [or PFS for that matter].

2021
Stealth Adapted Viruses As an Inadvertent Consequence of Polio Vaccines

"In a 1972 joint study by the US Food and Drug Administration (FDA) and the polio vaccine manufacturer, kidney cell cultures from 11 monkeys were set aside from polio vaccine production and tested for the presence of other viruses. All 11 cultures grew African green monkey simian cytomegalovirus (SCMV).

"This information was withheld from the public, arguably because there had been no reports of cytomegalovirus infections occurring in polio vaccine recipients. Nor was this information brought to light when I informed the FDA that the virus, which I had repeatedly cultured from a woman with the chronic fatigue syndrome (CFS), had unequivocally originated from SCMV."

"These findings are providing a new conceptual understanding of viruses. They can essentially become disguised as self or as a bacterial infection by incorporating either cellular or bacterial genetic sequences, respectively.

Molecular methods applicable to the identification of conventional viruses are not as reliable as performing sensitive virus cultures.

Of major significance is that the viruses can potentially act as carriers of disease-inducing cellular genes between individuals and even between animals and man."


https://recentlyheard.com/2021/05/22/stealth-adapted-viruses-as-an-inadvertent-consequence-of-polio-vaccines/

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General Science / Re: Herb and marijuana anxiety

« on: 17/11/2019 12:34:29 »

According to the nhs it increaces anxiety and paranoia

https://www.nhs.uk/live-well/healthy-body/cannabis-the-facts/

No, not in the overwhelming amount of adults who use it regularly it doesn't.

Once again....

"A small subset of susceptible individuals who may present with acute THC-induced psychosis or transient anxiogenic episodes. But in general, it does acquire a significant degree of anxiolytic efficacy."

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General Science / Re: Herb and marijuana anxiety

« on: 17/11/2019 12:32:16 »

The problem is when you spend 28 years hiding from the real world you can lose the ability to think rationally.

Oh I must be hiding from the real world and lost my ability to think rationally because I use Cannabis?

Oh lawdy.

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General Science / Re: Herb and marijuana anxiety

« on: 17/11/2019 12:27:48 »

Also the page discusses how often people are overdosing themselves on store bought goodies.

Wow, sounds like an epidemic lol. Here's the adverse effects listed in the very article you cited; "nausea, dizziness, headache".

Still waiting for the body of peer-reviewed clinical evidence indicating "significant psychological damage" from general Cannabis use in responsible adults.

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General Science / Re: Herb and marijuana anxiety

« on: 17/11/2019 12:13:13 »

they discuss how children are ingesting their parents 'medicine'. I don't include them in the category of responsible adults, do you?

Is this your example of the "significant psychological damage" from Cannabis use? Any parent that leaves their medicine accessible to children inherently falls into the category of an IRResponsible adult, and your implication that Cannabis use in general elicits "significant psychological damage" is nothing short of nonsense.

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General Science / Re: Herb and marijuana anxiety

« on: 17/11/2019 11:28:32 »

So you would be perfectly fine giving daily doses of cannabis to all children over 5 years of age then? It should be beneficial to their psychological development according to your way of thinking.

Once again, speaking of dishonest.... What part of "My comments are specific to the precise dosing of Cannabis in responsible adults" .... did you not comprehend?

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General Science / Re: Herb and marijuana anxiety

« on: 16/11/2019 21:18:02 »

Kind of dishonest if you ask me.

Speaking of dishonest.... the "significant psychological damage" you claim is nothing short of a fallacy, acquiring no merit whatsoever.

Thousands of years worth of cultural/medicinal use and the ever-expanding scientific/clinical interest in Cannabis clearly suggests the opposite of what you claim..

The old alarmist approach to "the dangers of Cannabis use" just doesn't apply anymore.

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General Science / Re: Herb and marijuana anxiety

« on: 16/11/2019 16:56:24 »

So you believe that smoking is beneficial?

The great thing is, Cannabis nor it's chemical constituents need to be combusted to obtain the medicinal/psychological benefits.

So how bout that "collective body of peer-reviewed clinical evidence"?

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General Science / Re: Herb and marijuana anxiety

« on: 16/11/2019 15:04:06 »

Marijuana is a class B drug and illegal in the UK you can get jail using or dealing in it

Do you have anything clinically-relevant to add?

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General Science / Re: Herb and marijuana anxiety

« on: 16/11/2019 14:59:03 »

They said that medical cannabis is very effective when it comes to anxiety.

Cannabis use is most often times effective in ameliorating and/or eliminating anxiety however, there is a flipside to take note of in a small subset of susceptible individuals who may present with acute THC-induced psychosis or transient anxiogenic episodes. But in general, it does acquire a significant degree of anxiolytic efficacy.

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General Science / Re: Herb and marijuana anxiety

« on: 16/11/2019 14:28:36 »

It tends to extract the joy out of them.

Funny because after 28+ years of use, I've yet to see an example of Cannabis in responsible users ever detracting from the amount of joy a person displays. In fact, the truth is in stark contrast to such a fallacy.

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General Science / Re: Herb and marijuana anxiety

« on: 16/11/2019 14:22:24 »

They are never the same once they have succumbed. It tends to extract the joy out of them.

Do you have some examples of how people permanently change once they've "succumbed" to responsible Cannabis use? Sounds frightening.... Got any pics?

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General Science / Re: Herb and marijuana anxiety

« on: 16/11/2019 14:18:04 »

I have seen what drugs of various kinds end up doing to people.

Various kinds of drugs? My comments are specific to the precise dosing of Cannabis in responsible adults and have nothing to do with other drugs or drug abuse. Let's stick to the topic shall we?

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General Science / Re: Herb and marijuana anxiety

« on: 16/11/2019 14:10:31 »

Well if you want to make your brain malfunction

Malfunction? In what ways precisely? And since I was referring to precise dosing in adults - What doses were used and at what age? More importantly, let's see the --> "collective body of peer-reviewed clinical evidence" <--

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General Science / Re: Herb and marijuana anxiety

« on: 14/11/2019 14:09:55 »

People who smoke it daily seem to suffer attention loss.

Such an effect is very much dose-dependent. In responsible users who precisely regulate doses, it actually elicits cognitive effects which are quite the opposite.

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General Science / Re: Herb and marijuana anxiety

« on: 14/11/2019 14:01:08 »

I think everyone just, on purpose, ignores the significant psychological damage that the drug can cause. Happy Mondays!

Having been a user for the past 28 years or so, I would enjoy seeing your list of "significant psychological damage" that Cannabis use elicits, along with a collective body of peer-reviewed clinical evidence to support such an uneducated notion.

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Physiology & Medicine / Re: Why do recovery times post-op vary from person to person?

« on: 07/11/2019 14:06:57 »

The primary reasons are post-operative immunosuppression variables/differences in glutathione expression, decrements in HLA-DR expression on monocytes and resultant bacterial elimination dynamics by neutrophils, skeletal muscle protein synthesis variables, differences in whole-body nitrogen balance, muscle glutamine-loss and differences in whole-body nitrogen balance.

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Complementary Medicine / Re: My family's personal experience with cancer and cannabis oil

« on: 01/11/2019 14:39:52 »

The mechanism of action for THC's anticancer/antineoplastic properties is mediated through the pro-apoptotic ceramide/p8-regulated autophagy pathway. However in stark contrast to these documented anti-cancer benefits of THC, there is a flipside; The copresence of the heparin-binding protein midkine/neurite growth promoting factor-2 can actually [increase] malignancy and resistance to the antitumor action of THC through the inhibition of the thc-evoked autophagy-mediated cell-death pathway through the stimulation of anaplastic lymphoma kinase. THC can also upregulate the proliferation of cancer cells through increased expression of the epidermal growth factor receptor ligand amphiregulin, via stimulation of anaplastic lymphoma kinase.

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