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Quote from: Limejuice on 27/07/2009 04:40:51I just want to post something I think about and am thankful for that goes against the grain of this thread but should be acknowldged. POIS has given something to me that's made me absolutely a better person and that is dicipline. Straight faced, no blinking, up most honesty - dealing with POIS has straigthened my self control and character. I think it should be said for myself. Not me. It has driven me absolutely mad before and led to a lot of self destructive behavior earlier on in my life, mostly out of frustration with its existence and girlfriend's DISBELIEF in its existence. It took 15 years before my sanity was once again in control, and I only managed that through absolute abstinence.
I just want to post something I think about and am thankful for that goes against the grain of this thread but should be acknowldged. POIS has given something to me that's made me absolutely a better person and that is dicipline. Straight faced, no blinking, up most honesty - dealing with POIS has straigthened my self control and character. I think it should be said for myself.
okay so one thing i've been poking around is histamine. http://en.wikipedia.org/wiki/Histamine_H3_receptor"The H3 receptor has also been shown to presynaptically inhibit the release of a number of other neurotransmitters (i.e. it acts as an inhibitory heteroreceptor) including, but probably not limited to dopamine, GABA, acetylcholine, noradrenaline, and serotonin."now about histamine itself:http://en.wikipedia.org/wiki/Histamine"Research has shown that histamine is released as part of the human orgasm from mast cells in the genitals."Now some of the symptoms of having too much histamine in the blood reminds me of POIS symptoms. Histadelia: This is a disorder, prominent in males, of toomuch histamine in the blood. Symptoms include hyperactivity, compulsions, obsessions, innertensions, blank mind episodes, phobias, chronic depression,and strong suicidal tendencies.Physical signs can include little tolerance for pain, rapidmetabolism, lean build, profuse sweating, seasonal allergies,and frequent colds.So, for POIS symptoms that last a few days, I'm thinking that maybe we have a problem with N-methyltransferase, the chemical that breaks down Histamine.... so after orgasm, Histamine gets in our blood, sits there for too long, and the symptoms develop... after a few days EVENTUALLY the excess Histamine is removed from the blood stream and the symptoms disappear.Just another random theory i have....
Counterpoints, would this Scientific American article be useful as a reference in wikipedia? Posted here in case others are interested: The Orgasmic Mind: The Neurological Roots of Sexual Pleasurehttp://www.scientificamerican.com/article.cfm?id=the-orgasmic-mind
man am i glad to see you guys still going strong... too bad the wiki page got cut down to size, since it's said you cant use a forum as a source of reference =( but at least the page is still upokay so one thing i've been poking around is histamine. http://en.wikipedia.org/wiki/Histamine_H3_receptor"The H3 receptor has also been shown to presynaptically inhibit the release of a number of other neurotransmitters (i.e. it acts as an inhibitory heteroreceptor) including, but probably not limited to dopamine, GABA, acetylcholine, noradrenaline, and serotonin."now about histamine itself:http://en.wikipedia.org/wiki/Histamine"Research has shown that histamine is released as part of the human orgasm from mast cells in the genitals."Now some of the symptoms of having too much histamine in the blood reminds me of POIS symptoms. Histadelia: This is a disorder, prominent in males, of toomuch histamine in the blood. Symptoms include hyperactivity, compulsions, obsessions, innertensions, blank mind episodes, phobias, chronic depression,and strong suicidal tendencies.Physical signs can include little tolerance for pain, rapidmetabolism, lean build, profuse sweating, seasonal allergies,and frequent colds.So, for POIS symptoms that last a few days, I'm thinking that maybe we have a problem with N-methyltransferase, the chemical that breaks down Histamine.... so after orgasm, Histamine gets in our blood, sits there for too long, and the symptoms develop... after a few days EVENTUALLY the excess Histamine is removed from the blood stream and the symptoms disappear.Just another random theory i have....
Quote from: demografx on 28/07/2009 00:17:24Counterpoints, would this Scientific American article be useful as a reference in wikipedia? Posted here in case others are interested: The Orgasmic Mind: The Neurological Roots of Sexual Pleasurehttp://www.scientificamerican.com/article.cfm?id=the-orgasmic-mindSure, add it if you like, as an external reference. I am not sure how it fits specifically with POIS though.
Quote from: Counterpoints on 28/07/2009 02:24:08Quote from: demografx on 28/07/2009 00:17:24Counterpoints, would this Scientific American article be useful as a reference in wikipedia? Posted here in case others are interested: The Orgasmic Mind: The Neurological Roots of Sexual Pleasurehttp://www.scientificamerican.com/article.cfm?id=the-orgasmic-mindSure, add it if you like, as an external reference. I am not sure how it fits specifically with POIS though.Right, that's why I wanted you to see it. I don't want to lessen credibility. The main plus is the idea of showing scientific acceptance of studying ORGASM, the science which is in it's infancy. I'll put it there, but feel free to remove it if you feel it's not a strong enough connection to POIS.I also have a question about POIS defined as "hours or days". It says elsewhere in wikipedia "needs days of rest". I wonder if only "days" would be more accurate than "hours/days". Marnia and the New York Times article talk about "hours" as a fairly widespread, universal, mild orgasmic aftereffect, unrelated to the dark severity of POIS, which lasts "forever", i.e., days or even weeks.
John, so the improvement is caused by cranberries or maybe a synergic effect of both. Cranberry has proved effects :- antibacterial (urinary system)- anti-inflammatory- anti-oxydantWiki :" One evaluates effects of cranberry polyphenols on cytochrome P450 enzymes involved in metabolism."Very very very interesting! Remember I have told about cytochrome P450 when we have a look on pancreas role on steroids synthesis (cholesterol to pregnenolone). Cytochome P450 c17 (with cytochrome p450 cc ) can convert cholesterol to pregnenolone, a steroid hormone in mitochondries.Cranberries juice may help to increase HDL cholesterol (10?).The problem for me is to find cranberries :/ [] Only supplements, dehydrated fruit or juice. Very expansive ...
Sure, add it if you like, as an external reference. I am not sure how it fits specifically with POIS though.
The range seems to be from hours to days, although days is more common here.... at some point the article will need a major renovation, although we'll have to be careful about how to approach it.
Quote from: Counterpoints on 28/07/2009 04:14:26The range seems to be from hours to days, although days is more common here.... at some point the article will need a major renovation, although we'll have to be careful about how to approach it.Then maybe it would be easier and also appear more consistent (for now) if we change "needs days of rest" to "needs hours or days of rest"?
WHO UPDATEPronobis, thank you! It's wonderful that you got a contact name who we can now hold accountable in this bureaucracy! As you indicated, I will send the follow up email today. Thanks again for calling their Switzerland headquarters, and for your persistent follow-up.
Quote from: demografx on 28/07/2009 17:45:05WHO UPDATEPronobis, thank you! It's wonderful that you got a contact name who we can now hold accountable in this bureaucracy! As you indicated, I will send the follow up email today. Thanks again for calling their Switzerland headquarters, and for your persistent follow-up.Thank you too. I hope it will work
From my end, I am getting some understanding on what is happening to me post Orgasm. Typically, post Orgasm, after a brief relaxed mode, I sense I get into a physically tense state for days. This invariably happens even with me taking actions to stay relaxed. This is similar to, or same as Psychosomatic disorder (i.e., excess stress in the body). I had attempted Orgasm for continuous 5 days, during which the excess stress (Psychosomatic) had triggered an auto-immune problem. This has manifested in me, in the form of Psoriasis. I had attempted Orgasm during my Psoriasis attack. I have experienced the same Post Orgasm stress for few days, that does not impact Psoriasis attack differently (with 1 day orgasm). I did not have heart to try continuous days post Psoriasis - I would presume this might aggravate my condition.]
Quote from: Defsync on 19/07/2009 03:43:24man am i glad to see you guys still going strong... too bad the wiki page got cut down to size, since it's said you cant use a forum as a source of reference =( but at least the page is still upokay so one thing i've been poking around is histamine. http://en.wikipedia.org/wiki/Histamine_H3_receptor"The H3 receptor has also been shown to presynaptically inhibit the release of a number of other neurotransmitters (i.e. it acts as an inhibitory heteroreceptor) including, but probably not limited to dopamine, GABA, acetylcholine, noradrenaline, and serotonin."now about histamine itself:http://en.wikipedia.org/wiki/Histamine"Research has shown that histamine is released as part of the human orgasm from mast cells in the genitals."Now some of the symptoms of having too much histamine in the blood reminds me of POIS symptoms. Histadelia: This is a disorder, prominent in males, of toomuch histamine in the blood. Symptoms include hyperactivity, compulsions, obsessions, innertensions, blank mind episodes, phobias, chronic depression,and strong suicidal tendencies.Physical signs can include little tolerance for pain, rapidmetabolism, lean build, profuse sweating, seasonal allergies,and frequent colds.So, for POIS symptoms that last a few days, I'm thinking that maybe we have a problem with N-methyltransferase, the chemical that breaks down Histamine.... so after orgasm, Histamine gets in our blood, sits there for too long, and the symptoms develop... after a few days EVENTUALLY the excess Histamine is removed from the blood stream and the symptoms disappear.Just another random theory i have....You could try taking an antihistamine?