I am a female in my mid 30s and I've begun having "hangovers" from masterbation recently. I get tiredness for 1-3 days, feelings of mild anxiety, unreality/lack of concentration and headache and sometimes loss of appetite...I just generally feel "down". I have experimented several times with stopping for weeks and starting up again and it seems linked to orgasm and nothing else. I have never had any difficulty with this before so I'm not sure why I would suddenly develop a psychological problem with sex. I have had symptoms of CFS which my sister is diagnosed with, and suffered a head injury last year in a car accident. I understand that many people develop CFS or have it worsen after being injured or traumatized in some way.

Mallory, if you are getting these problems also from oral sex, it may not be POIS or may be something in addition to POIS. POIS occurs post-orgasm, so it should not happen after you don't have one. There is a condition that causes headaches and tiredness/fatigue that can be excaserbated by any akward head/neck positions (such as occur during oral sex particularly), it is caused by the cerebellar tonsils at the back of your brain slipping downward through the skull into the spinal area and getting pressure, especially from certain head positions. Also, TMJD Temperomandibular Joint Disorder, can cause headaches and oral sex can make it worse.