[lauracostis]

Woow very nice article Demo !

Very happy to see more and more scientifics and doctors  look "our" Pois as a serious condition.

So, I really would like to have the full article
But it seems to confirm the cytokins release with orgasm, explaining the flu-like symptoms. It may be confirmed by M Waldinger's study in the next months. But there are a lot dark points like the role of sexual hormones and cortisol. I imagine the normal cortisol function would be to regulate the cytokins release. What happens if adrenal glands are "busy" (DHEA x5 or hormones/testosterone homeostasis after orgasm) ? 
No more details on cognition symptoms.
But I'm surprised by the solution given. Nonsteroidal anti-inflammatory drugs taken 1 day or 2 after orgasm ?!?
It supposes the 2 cases are long (7 days?). But why not before and why not continuous treatment to come back to a normal sexual frequency ?

Anyway, we already talk about NSAI. A woman have succes when taking ibuprofen some hours before orgasm (case 148). Another take 3 ibuprofen to alleviate pains post orgasm (case 158).

NSAI? i hope Dr. waldingers cure is better than NSAIs. thats like shooting an elephant with a bee-bee gun. although in the past i remember getting some relief from the initial stage right after an o from ibprophen.

[demografx]

CCconfucius re SSTAR

CCc, I heard back from SSTAR's Yvonnada McNeil, (email: ymcneil AT acog.org ) - and rather than wait for the merry-go-round through her, I simply emailed back Ms. McNeil and asked her to forward my letter + attachment to Jane Ashby. So we're one step closer.

I tried to contact the author a year-and-a-half-ago. Maybe she has been following our forum?

[demografx]

NSAI? i hope Dr. waldingers cure is better than NSAIs. thats like shooting an elephant with a bee-bee gun. although in the past i remember getting some relief from the initial stage right after an o from ibprophen.

Laurac, you bring up a very interesting point, in my opinion: this Forum has vastly more experience with a huge number of patients and treatments and sophistication than anyone else out there!

Our big problem is that we alone just don't have the medical-research expertise and facilities to take this huge goldmine to the next level!

[pyropeach]

Woow very nice article Demo !

Very happy to see more and more scientifics and doctors  look "our" Pois as a serious condition.

So, I really would like to have the full article
But it seems to confirm the cytokins release with orgasm, explaining the flu-like symptoms. It may be confirmed by M Waldinger's study in the next months. But there are a lot dark points like the role of sexual hormones and cortisol. I imagine the normal cortisol function would be to regulate the cytokins release. What happens if adrenal glands are "busy" (DHEA x5 or hormones/testosterone homeostasis after orgasm) ? 
No more details on cognition symptoms.
But I'm surprised by the solution given. Nonsteroidal anti-inflammatory drugs taken 1 day or 2 after orgasm ?!?
It supposes the 2 cases are long (7 days?). But why not before and why not continuous treatment to come back to a normal sexual frequency ?

Anyway, we already talk about NSAI. A woman have succes when taking ibuprofen some hours before orgasm (case 148). Another take 3 ibuprofen to alleviate pains post orgasm (case 158).

NSAI? i hope Dr. waldingers cure is better than NSAIs. thats like shooting an elephant with a bee-bee gun. although in the past i remember getting some relief from the initial stage right after an o from ibprophen.

I think that should be NSAID....

[Vandemolen3]

NSAID's after an O helps a bit against the myalgia and joint pain. And I use Xyzal direct after an O against allergic reactions.

I don't know if it helps when taking NSAID before an O.

But what I know is that NSAID's are not good for the body. So you can't use the daily. Using NSAID a lot can cause arrhythmias.

[daveman]

  Oh, and btw, I'm in the States now back from China...talk about culture shock/jetlag.

Welcome back!!

[alices_wonder]

Dear all,
    Firstly, I do not suffer from POIS but my partner does. Last January I was diagnosed with Adult ADD. My symptoms: brain fog, being moody, lack of concentration, inability to finish a sentence, memory loss, depression, fatigue, headaches and so forth were remarkably similar to that of my partner, post ejaculation. I do not come from a scientific background but I have wondered if there is a hormonal issue in his frontal lobe and would a slow release ADD medication like Atomoxetine a norepinephrine reuptake inhibitor, help deal with some of the symptoms and make life a little more manageable. What do you think?

[Dr. Matt]

Hey Gang,

As many of you may know, Zinc Lozenges are effective against many types of viruses, and some bacterial infections. I have had some relief from the POIS symptoms from using zinc lozenges during the day, I would like to know if anyone can corroborate my results. I use the "Cold Ease" brand, in the pharmacy section of any major grocery store. My personal results include:

1. Dissipation of the fog-like symptoms.
2. Deeper breaths
3. Increase in clarity of thought
4. Able to focus on analytical / problem solving activities.

The effective time frame can be roughly 1-2 hours, but that is from my perspective.

Please let me know

Dr. Matt

[demografx]

Dear all,
    Firstly, I do not suffer from POIS but my partner does. Last January I was diagnosed with Adult ADD. My symptoms: brain fog, being moody, lack of concentration, inability to finish a sentence, memory loss, depression, fatigue, headaches and so forth were remarkably similar to that of my partner, post ejaculation. I do not come from a scientific background but I have wondered if there is a hormonal issue in his frontal lobe and would a slow release ADD medication like Atomoxetine a norepinephrine reuptake inhibitor, help deal with some of the symptoms and make life a little more manageable. What do you think?

Welcome, Alice! Stimulants help me, but we're all very different. And none of us are really qualified to give medical advice, especially sight unseen over the internet. I say that because I don't believe any healthcare professional should attempt advice over the internet.

Please again accept our warm invitation to this group. We have many resources which might ultimately help you find the right advice. We have all been struggling with similar issues for many years.

Here are some resources:

Filling out the POIS survey created by "Counterpoints" will enable you to share POIS information and details with others here, as well as with outside researchers.
http://pois.olympe-network.com/

Our new POIS Information Website, built by "mat780", is here:
http://sites.google.com/site/POISwebsite/

Please see "B_Jim"'s POIS Summary of All Cases, here as well as others on the Web. This includes remedies that we have tested, and results.
http://www.thenakedscientists.com/forum/index.php?topic=6576.msg149009#msg149009

"Girlwind" has created an excellent POIS Video:

Our new POIS chatroom (realtime chat). Invite or visit another member(s) there, ANY TIME. We can all get to know each other better:
http://forums.delphiforums.com/POIS/chat

POIS Research Study

We have a copy of the first and only formal medical investigation on POIS by Dr. Marcel Waldinger,MD and Dr. Dave Schweitzer, MD.

There are 2 ways to get it: (1) if you want a PDF copy, send me a Private Message (PM) with your regular email address (use "AT" instead of "@" ) and I'll send you back the PDF. Or, if you prefer, (2) I can simply reply with a Private Message (no regular email needed) and provide you with a simple text version embedded in your PM.

To send a Private Message, click on "Messages" at the top of this page. At the Messages page, click on "New Message". From that point on, it works just like posting a message here, except that it only goes to the person(s) you designate.

Remember to put a quote around my name, i.e., "demografx".


New York Times article,

January 20, 2009
Mind
Sex and Depression: In the Brain, if Not the Mind
By RICHARD A. FRIEDMAN, M.D.
http://www.nytimes.com/2009/01/20/health/views/20mind.html?_r=1&scp=1&sq=friedman%20sexual%20January%2020&st=cse

- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -

In addition to serving our own informational interests, the resources listed above can be useful for you to show our credibility to the medical world - which often shows little understanding and is sometimes skeptical of our condition: POIS has scientific underpinnings and POIS is not "just another psychological problem" related to sex - to be treated by the psychiatric/psychotherapeutic community. All of this information can greatly help you to fight the immediate reaction of some doctors: so just tell them, "IT'S NOT 'ALL IN OUR HEADS'! "

Also, it can be helpful when dealing with medical professionals to point out the successful existence of our rapidly growing forum, which has already been referenced in respectable sources such as the British Medical Journal and wikipedia:
http://en.wikipedia.org/wiki/Postorgasmic_illness_syndrome

For over 3 years, our POIS forum has attracted over 150 POIS sufferers worldwide who have posted here, plus over 700,000 page visits. Not bad for a rare malady!

[Dr. Matt]

As far as the NSAID issue. I had been using that as well, it helps decrease "Bad" ecosonoids as described by Dr. Barry Sears, MIT Lipid Biochemist. I have personally found that steroidal anti-inflammitories work better for me. I take 5mg of Prednisone pre-intimacy. That seems to really take the edge off and in some cases significantly reduces the refractory time between intimacy. Typically, prednisone would suppress the testosterone surge shortly after intimacy, and increase the refractory period in normal subjects. For myself and one other person that I know of, prednisone does the exact opposite.

We still have not come to a definitive conclusion as to why the conclusion of intimacy is met with such a destructive immune response. Is it comparable to type one diabetes where the beta cells of the pancrease are destroyed by antibodies? If so, what is being attacked and what specifically causes the associated fatigue?

Best,

Dr. Matt

[horizon]

Please let me know

zinc has no effect on me.

[daveman]

We still have not come to a definitive conclusion as to why the conclusion of intimacy is met with such a destructive immune response. Is it comparable to type one diabetes where the beta cells of the pancrease are destroyed by antibodies? If so, what is being attacked and what specifically causes the associated fatigue?

Best,

Dr. Matt

Could the information in this article somehow be involved?

http://www.scientificamerican.com/blog/post.cfm?id=how-the-immune-systems-t-cells-seem-2010-05-03

In the article siting the NSAID solution, it mentions cytokines are produced during orgasm, which seem to cause the symptoms, yet the above article indicates that if another cytokine, IL-4, a protein that suppresses inflamation is somehow removed or not produced meninges tissues can flare up and cause POIS like symptoms.

Could there be some kind of failed transition, which instead of producing IL-4 (interluken-4, excusd possible spelling errors), produces some other protein? Perhaps abnormal anti-bodies inhibit the T-cell transmutation or modify it?

As I've said before, I'm just an e-Eng., but this line has me curious!

[horizon]

Now theres a new male pill,
http://www.telegraph.co.uk/health/healthnews/7857262/Scientists-invent-first-male-contraceptive-pill.html
http://www.israel21c.org/201006238085/health/a-birth-control-pill-for-men
this one removes a vital protein in sperm.

In the mature sperm, messenger RNA (mRNA) is produced by DNA in the sperm's nucleus and it is this mRNA, which directs protein synthesis in the sperm, Breitbart's lab showed. In his breakthrough he describes how mitochondrial ribosomes are active in synthesizing nuclei-encoded mRNA proteins. This led to his realization that if he could stop protein synthesis in the sperm, they wouldn't manage to survive in the uterus.

I dont know if this would effect POIS.
There is lots on web regarding the links between mRNA, fatigue, cytokine Glycogen etc.
but to be honest i dont understand it

[demografx]

We still have not come to a definitive conclusion as to why the conclusion of intimacy is met with such a destructive immune response.

There is no solid evidence that POIS is an immune response, certainly not across-the-board.

[lauracostis]

Dhat syndrome-   as a functional somatic syndrome: developing a sociosomatic model.


Dhat syndrome is a widely recognized condition from the Indian subcontinent with fatigue and preoccupation with semen loss as the main presenting symptoms. This condition has been considered to be a culture-bound syndrome, but little is known about its illness characteristics and similarities with other conditions with medically unexplained symptoms. In this paper we review the current research on dhat syndrome, discuss its similarities and differences with other functional somatic syndromes, and propose an integrated model that incorporates both psychological and sociocultural factors. Under stress, persons predisposed to amplification of somatic symptoms and health anxiety may focus attention on physiological changes such as turbidity of urine and tiredness, and misattribute them to loss of semen in the light of widely prevalent health beliefs. This attribution may then be confirmed by traditional views as well as by local practitioners subscribing to similar beliefs. The clinical and research implications of understanding this condition as a functional somatic syndrome, the presentation of which is significantly modified by culture, are discussed.

this is what the second case in that new article we found was talking about.
what i posted was an abstract on an article about Dhat syndrome. i would like to read more about this

[Vandemolen3]

Has anyone also suffer from tonsil stones? This is a few days after an O.

[daveman]

We still have not come to a definitive conclusion as to why the conclusion of intimacy is met with such a destructive immune response.

There is no solid evidence that POIS is an immune response, certainly not across-the-board.

Although, soley based on administration of testoserone (for instance) to relieve symptoms, we can't necesarily rule out auto-immune response.

It could well be that within the complex process, some auto-immune disorder is causing the problem, and testoserone, or progesterone etc. breaks the cycle before the auto-immune system reacts. Like maybe blocking GnRH (let's say) which is causing an abnormal auto-immune reaction.

[demografx]

Daveman, I agree. We just don't know definitively one way or the other. Or if some cases are immune-related, others not.

[demografx]

*****************************************************************

Everyone, I just received a lengthy and very hopeful email from Prof. dr. Waldinger, but the contents are confidential. Let's hope for great success in his continuing POIS Medical Research and publication efforts!

*****************************************************************

[Vandemolen3]

*****************************************************************

Everyone, I just received a lengthy and very hopeful email from Prof. dr. Waldinger, but the contents are confidential. Let's hope for great success in his continuing POIS Medical Research and publication efforts!

*****************************************************************

That's great news. Well done!
Let's all be patient.

In the meanwhile let's exchange garlic recipes.