1

Physiology & Medicine / Re: What are the available cancer strategies?

« on: 28/05/2019 08:42:33 »

I don’t think I have a tried & tested or failed cancer therapy but I have been thinking about a cancer strategy that can help us find a cure for cancer. It involves a newly developed technology called NGS or Next Generation Sequencing. NGS technology has huge applications in the field of biotechnology, genetics, oncology, etc. and could help us detect various anomalies at cellular level. NGS software can sequence RNA in less time and help us analyse the output data. Now let me explain what output data is if you aren’t familiar with NGS. This technology sequences RNA and collects the data of the total RNA population in a particular cell. The NGS data analysis software gives us this output data after running NGS and allows us to investigate and understand gene expression. RNA is very important to our research because analysing RNA allows us to look at the changes taking place at molecular level that may be causing mutations or errors leading to various gene expressions. The changes or modifications taking place at molecular level could be alternative splicing which give different transcripts from one single gene sequence, the post-transcriptional modifications of mRNA like polyadenylation and capping  and the amino acids that are produced after the alterations. All of this could cause different gene expression leading to some anomaly. I feel like NGS and RNA sequencing could help us figure out what is causing the mutations and why the cancer cells become unresponsive to cell signals from healthy cells. It could also give us an insight into the level of gene expression and how the expression shuts off or gets activated. I haven’t really done a lot of research on this topic so corrections or suggestions are really welcome. I have studied immunology which led me to looking at RNA sequencing in a different perspective.

Hi Steph, thanks for your input.
How would you treat cancer with that?

I think finding a cure would come very late in the picture because right now what we can do with the NGS software is look at the gene expression arising from splicing and translation of that spliced mRNA. And also, try and understand the relation of the mutations taking place in the cell to the cancer cells getting developed. I know we are nowhere close to solving it but I guess with this technology our perspective of looking at cancer cells will change. I'm really not an expert. Just some estimations from my end 

2

Physiology & Medicine / Re: What are the available cancer strategies?

« on: 27/05/2019 09:34:46 »

I don’t think I have a tried & tested or failed cancer therapy but I have been thinking about a cancer strategy that can help us find a cure for cancer. It involves a newly developed technology called NGS or Next Generation Sequencing. NGS technology has huge applications in the field of biotechnology, genetics, oncology, etc. and could help us detect various anomalies at cellular level. NGS software can sequence RNA in less time and help us analyse the output data. Now let me explain what output data is if you aren’t familiar with NGS. This technology sequences RNA and collects the data of the total RNA population in a particular cell. The NGS data analysis software gives us this output data after running NGS and allows us to investigate and understand gene expression. RNA is very important to our research because analysing RNA allows us to look at the changes taking place at molecular level that may be causing mutations or errors leading to various gene expressions. The changes or modifications taking place at molecular level could be alternative splicing which give different transcripts from one single gene sequence, the post-transcriptional modifications of mRNA like polyadenylation and capping  and the amino acids that are produced after the alterations. All of this could cause different gene expression leading to some anomaly. I feel like NGS and RNA sequencing could help us figure out what is causing the mutations and why the cancer cells become unresponsive to cell signals from healthy cells. It could also give us an insight into the level of gene expression and how the expression shuts off or gets activated. I haven’t really done a lot of research on this topic so corrections or suggestions are really welcome. I have studied immunology which led me to looking at RNA sequencing in a different perspective.

3

Geek Speak / Re: What is the best screen recording software?

« on: 22/05/2019 06:53:59 »

I am using movavi  and I really liked it
see if you like it too movavi.com

4

Geek Speak / Re: Can the problem with windows 10 anti virus be cured

« on: 22/05/2019 06:47:20 »

I personally don't suggest antivirus as it's slower the processes and not even that much helpful.

5

Technology / Re: Best power bank for android?

« on: 13/05/2019 09:02:30 »

I am using syska and I am really happy with it.

6

Technology / Re: Where is the sweet spot on a baseball bat?

« on: 13/05/2019 08:53:25 »

it's really great to see that so many people know about it 

7

Technology / Re: How are moulds made for metal casting, such as making a ring?

« on: 29/01/2019 13:46:45 »

Instead of using a clay mould, I would suggest that you make use of a sand mould as a base of casting the molten iron. The clay mould might break or not be able to hold the molten metal properly. However, a sand mould could prove ideal as it would be able to withstand the high temperature of the molten iron. In fact, sand castings are most widely used for nearly 70% of ferrous casting around the world. In fact, the sand casting industry enjoys high demand from major end-users like automobile and industrial machinery. This is because, preparing a sand casting is probably cheaper, than other casting methods. Therefore, I feel that a sand-cast would sufficiently suit your need. To answer your second question, since you do not have a furnace or a gas cooker, a sand cast would be ideal for a makeshift brick furnace.

I hope this helped. Thanks.

8

General Science / Re: It's Impossible !!!..but How Can I Clap My Hands ?

« on: 29/01/2019 13:45:46 »

It's a logical fallacy.  Don't buy into it.

Your hands are not halving the distance with each successive movement, they are heading towards each other with a definite acceleration.  Given that acceleration and starting points of the hands, one can mathematically show the duration of the clap and the position of the hands at that clap.

This message brought to you by The Council of People Who Are Sick of Seeing More People

Hahahaha! Totally agree! Best answer though! Thanks, man!

9

General Science / Re: Which way faster, east or west ?

« on: 29/01/2019 13:43:27 »

If you threw a ball from a moving car, it would travel with the car for a bit before gravity pulled it down....momentum.
If you pulled the chair out from under someone as they were sitting down, they would miss the chair and bust their a$$....deviance.

Now, my belief is that traveling westward would be faster. There's not enough momentum from the rotation of the earth to make a difference either way. However, the earth would move enough that a certain point (chair) would be moved from under the plane (a$$). So, I would speculate that west would be faster. (Not counting time changes)
But, my mind is now debating with itself. Great. I know it doesn't take much, but now I'm confused. Thanks alot!

Welcome to the forum, Mawea.

Wow, this is the best answer! Thanks, man

10

Plant Sciences, Zoology & Evolution / Re: What's the best fish bait?

« on: 29/01/2019 13:41:23 »

I was speaking generally. It's no use using small bait if you're after big fish. Anyway, the best bait for catfish is a mousefish!

Totally agree! This has never disppointed me!

11

General Science / Re: What do you find difficult in life?

« on: 18/01/2019 05:32:43 »

Hello, I'm a new member as understood.
I'm joining a physics project competition soon and I gotta find a creative idea. And in order to find this, I ask for telling me the difficulties you live.
Maybe I can find a good idea to put it away using my physics project and write you what to do...

Thanks for paying attention

Note: Sorry if I used this language wrong.

6m10URs1337
huseyinsumbul@hotmail.com

The difficulty I have is not being able to know what to choose as my career. I am working as a research scientist but I love writing but then I like science, too. And again I want to work for my society as well. I hope I wasn't supposed to pose a physics question on this thread.

12

General Science / Re: Do babies automatically stop breathing underwater?

« on: 18/01/2019 05:24:19 »

A reflex called the bradycardic response makes babies hold their breath and open their eyes when submerged in water, says Jeffrey Wagener, a pediatric pulmonologist in Colorado. (Parents can cause this same reaction by blowing in their baby's face, a response that disappears after about 6 months. I guess this must be the reason. But is it really safe to teach a baby only months old to swim?

13

The Environment / Re: Could the Earth ever be completely underwater?

« on: 17/01/2019 06:07:52 »

Colin asks:

Regardless of how many days and nights it rains, is there enough water in the Earth's climate system for the entire Earth to actually flood?

Any thoughts?

I guess if it rains on all of the continents at the same time then maybe it could lead to flooding. But there should be enough water in the seas to keep the lands underwater. The normal setting is that the water from land flows into the waterbody giving us the land back. We already have enough on earth to put the whole of earth underwater. If the glaciers melt the whole of earth will flood due to increase in sea levels

14

General Science / Re: Boil, or freeze, or both?

« on: 17/01/2019 06:03:26 »

If a cup of water were taken outside the International Space Station and observed, would it boil off, freeze solid, or do both (but not at the same time)?

I'd be interested in everyone's opinion...

I think it would end up freezing.

15

General Science / Re: What evidence is there for using ozone as a medical treatment?

« on: 17/01/2019 06:01:53 »

Ozone is a very reactive substance (it will even react with itself at sufficiently high pressures). It will oxidize any C=C double bonds instantaneously (even at –78 °C), producing extremely toxic (and potentially explosive) ozonides and malozonides (which can promptly react with proteins containing free thiols and free amines...)

Given the extreme reactivity of ozone, I cannot believe that it would have any selectivity for cancer or microorganisms over the rest of the human body, and therefore would not be effective as any treatment other than euthanasia... And given the history provided by RD, I am inclined to believe that anyone recommending ozone treatment is a quack or has been taken in by one.

Yes, how does ozone treatment even make sense? That just sounds wrong and hazardous

16

Plant Sciences, Zoology & Evolution / Re: Pictures of Wildlife...the Birds and the Bees etc etc

« on: 16/01/2019 07:14:52 »

Fennec fox (Vulpes zerda)
Once (in Sinai) we had a wild male fennec that (quite) apparently fell in love with our female house cat 
I don't think anyone got much sleep that week  []
 []

Fennec fox (Vulpes zerda)
Once (in Sinai) we had a wild male fennec that (quite) apparently fell in love with our female house cat 
I don't think anyone got much sleep that week  []
 []

Alandriel Check your url on your piccy, I tried to sort it but it seems fine! Maybe missed part of it at the start although I bet you just copied the wrong url is it photobucket!

Here is the Yellow Jacket Nest!

I have not seen such a picture! What is that? I can see some nest but I am not sure what it is.

17

Geek Speak / Re: Victim of an Adult Site Blackmail Email Hoax?

« on: 16/01/2019 07:12:22 »

Scary stuff...

Just one more reason to get (or improvise) a lens cap for your webcam. It's unhackable and practically free, and all you have to do is remember to take it off before your video conference starts (and then put it back in place before picking your nose, or singing along to Miley Cyrus, or *ahem* whatever else you would worry about being shared with the world...)

Oh, I have read about this before but never in such depth! Thank you for sharing this. The members are so helpful on this forum.

18

General Science / Re: Science Photo of the Week

« on: 16/01/2019 07:05:59 »

African Skull Fills Gap, Fuels Debate


920x920.jpg (66.49 kB . 741x920 - viewed 25229 times)

Remains of the hominids that lived in Africa between a million and half a million years ago are frustratingly rare in the fossil record. Bones from this time period have been recovered in Europe and Asia, but the paucity of finds from Africa has prevented a full understanding of just what members of the species Homo erectus looked like. Indeed, some paleontologists posit that hominids from this time period should be divided into multiple lineages, whereas others suggest that there was simply wide variation within H. erectus. A discovery described today in the journal Science is helping to fill the fossil gap.
Richard Potts of the National Museum of Natural History in Washington, D.C., and his colleagues found 11 fragments of a single hominid skull during excavations at an archaeological site in Olorgesailie, Kenya. Together these finds mark the first discovery of ancient human bone at the site since exploration began in 1942. Based on radiometric dating and sedimentary evidence, the team estimates that the fossil is between 900,000 and 970,000 years old. The skull is from an adult or near-adult and shares some features with H. erectus. If it is a member of this species, it is a very petite representative. The researchers note that it is the smallest individual yet known from the time interval spanning 1.7 million and half a million years ago. Because many of the tools recovered from the same site are large and would have required significant strength and size to handle, Potts and his collaborators conclude that there was wide physical variation in the population to which this hominid belonged, with both large and small individuals present.
Other researchers interpret the new find differently, however. “[The skull] doesn't look like anything else we know so far,” contends Jeffrey H. Schwartz of the University of Pittsburgh, who penned an accompanying commentary in Science. He argues that a number of the fossils categorized as H. erectus show too much variation from the original, or type, H. erectus skull discovered in the late 19th century in Java to be considered members of the same species.

SOURCE SCIENTIFIC AMERICAN.COM

Men are the same as women...just inside out !

Wow, this is such a nice one! Thanks for sharing this. I totally enjoyed reading this post