[scientizscht (OP)]

What is Glucose-responsive insulin, what its structure and how it works?
Thanks!

[Bored chemist]

As far as I can tell, Glucose-responsive insulin is just an idea.
People are working towards making it.
It doesn't exist yet.

[scientizscht (OP)]

As far as I can tell, Glucose-responsive insulin is just an idea.
People are working towards making it.
It doesn't exist yet.

I think they have found molecules to do it, bit it hasn't been developed into a medicine yet. But how is it supposed to work anyway?

[evan_au]

In the human body, the pancreas produces more or less insulin depending on the level of circulating glucose.
This keeps the level of glucose in the blood within a safe range.

So, normal insulin is glucose-dependent.
- Insulin Resistance and Diabetes interferes with this natural feedback loop which regulates the level of glucose in the blood.
- I imagine researchers are looking for automatic insulin pumps which do an equally good job of regulating glucose levels.

https://en.wikipedia.org/wiki/Diabetes_mellitus

[scientizscht (OP)]

In the human body, the pancreas produces more or less insulin depending on the level of circulating glucose.
This keeps the level of glucose in the blood within a safe range.

So, normal insulin is glucose-dependent.
- Insulin Resistance and Diabetes interferes with this natural feedback loop which regulates the level of glucose in the blood.
- I imagine researchers are looking for automatic insulin pumps which do an equally good job of regulating glucose levels.

https://en.wikipedia.org/wiki/Diabetes_mellitus

No I don't think it's that.

Example: Ziylo company.

They said they produced molecules that...

Any idea?

[Colin2B]

One idea is to add molecules to the insulin so it doesn’t react with glucose, but the molecules do react to glucose and so release the insulin. Other ideas are available.
As @Bored chemist says, it still an early idea, but some molecules are being experimented with.