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He did have quite bad dermatitis on his hands for a while at the time - was told that was the teak. So fits with thsi Finnish report.The curcumin link sounds very interesting. What diagnostic data would you like?Thanks so much. []
Malaria remains a major global health concern.New, inexpensive, and effective antimalarial agents are urgently needed.http://www.stemcellresearchfoundation.org/Research/ScientistMicroscopePhoto2.jpgHey! The old Ayurvedal/Chinese medicine is finally joining western orthodox medicine and is already giving very promising results, perhaps thanks to the immigrants from Asia to the USA/UK who are now leading big research labs.Curcumin alone (Turmeric) is being extensively tested for various dreadful human diseases: hundreds of scientific reports and astonishing data...Let's curry on!iko ...these news come from the original Continent: Curcumin-artemisinin combination therapy for malaria.Nandakumar DN, Nagaraj VA, Vathsala PG, Rangarajan P, Padmanaban G.Department of Biochemistry, Indian Institute of Science, Bangalore 560 012, India.Artemisinin and curcumin show an additive interaction in killing Plasmodium falciparum in culture. In vivo, 3 oral doses of curcumin following a single injection of alpha,beta-arteether to Plasmodium berghei-infected mice are able to prevent recrudescence due to alpha,beta-arteether monotherapy and ensure almost 100% survival of the animals.Antimicrob Agents Chemother. 2006 May;50(5):1859-60. But this paper came first: Curcumin for malaria therapy.Reddy RC, Vatsala PG, Keshamouni VG, Padmanaban G, Rangarajan PN.Dept.Int.Med.The Univ.Michigan Med.School, Ann Arbor, MI 48109-0360, USA.Malaria remains a major global health concern. New, inexpensive, and effective antimalarial agents are urgently needed. Here we show that curcumin, a polyphenolic organic molecule derived from turmeric, inhibits chloroquine-resistant Plasmodium falciparum growth in culture in a dose dependent manner with an IC(50) of approximately 5 microM. Additionally, oral administration of curcumin to mice infected with malaria parasite (Plasmodium berghei) reduces blood parasitemia by 80-90% and enhances their survival significantly. Thus, curcumin may represent a novel treatment for malarial infection.Biochem Biophys Res Commun. 2005 Jan 14;326(2):472-4.http://www.sb-roscoff.fr/CyCell/Images/plasmodium1.jpg
Just so I understand the distinction: is the cryptic (no known cause) form one where there IS an external cause, e.g. teak dust, but it's not possible to identify exactly what it is. And is the scleroderma related form one in which the alveolitis arises because of an internal malfunction in the immune system?
...even nanotechnology experts are payingattention to Curcuma longa!Polymeric nanoparticle-encapsulated curcumin (nanocurcumin):a novel strategy for human cancer therapy. Bisht S, Feldmann G, Soni S, Ravi R, Karikari C, Maitra A, Maitra A. ABSTRACT:BACKGROUND: Curcumin, a yellow polyphenol extracted from the rhizome of turmeric (Curcuma longa), has potent anti-cancer properties as demonstrated in a plethora of human cancer cell line and animal carcinogenesis models. Nevertheless, widespread clinical application of this relatively efficacious agent in cancer and other diseases has been limited due to poor aqueous solubility, and consequently, minimal systemic bioavailability. Nanoparticle-based drug delivery approaches have the potential for rendering hydrophobic agents like curcumin dispersible in aqueous media, thus circumventing the pitfalls of poor solubility.RESULTS: We have synthesized polymeric nanoparticle encapsulated formulation of curcumin - nanocurcumin - utilizing the micellar aggregates of cross-linked and random copolymers of N-isopropylacrylamide (NIPAAM), with N-vinyl-2-pyrrolidone (VP) and poly(ethyleneglycol)monoacrylate (PEG-A). Physico-chemical characterization of the polymeric nanoparticles by dynamic laser light scattering and transmission electron microscopy confirms a narrow size distribution in the 50nm range. Nanocurcumin, unlike free curcumin, is readily dispersed in aqueous media. Nanocurcumin demonstrates comparable in vitro therapeutic efficacy to free curcumin against a panel of human pancreatic cancer cell lines, as assessed by cell viability and clonogenicity assays in soft agar. Further, nanocurcumin's mechanisms of action on pancreatic cancer cells mirror that of free curcumin, including induction of cellular apoptosis, blockade of nuclear factor kappa B (NFkappaB) activation, and downregulation of steady state levels of multiple pro-inflammatory cytokines (IL-6, IL-8, and TNFalpha).CONCLUSIONS: Nanocurcumin provides an opportunity to expand the clinical repertoire of this efficacious agent by enabling ready aqueous dispersion. Future studies utilizing nanocurcumin are warranted in pre-clinical in vivo models of cancer and other diseases that might benefit from the effects of curcumin.J Nanobiotechnology. 2007 Apr 17;5(1):3 [Epub ahead of print]http://www.bnl.gov/bnlweb/pubaf/pr/photos/2002/nanoparticles-w.jpg
Hi iko,He's at homeNo apparent side effects from the medicationIs eating and sleeping OK. Water - he tends to drink tea and coffeeHe weight is about the same as always, maybe a little less perhaps due to stress of being in hospital, getting the diagnosis etcI've just read your cod liver oil posts and will suggest he starts taking some - it can do no harm!janetah
Hi iko,I did read about the asylum seekers.. and also saw mention of possible benefit for Parkinson's disease, which another relative has, I will tell him.What was the miracle cure involving your grandfather?Will await news of oregan. thanks again for your help todayjanetah []
Hello again iko,Guess Carolyn's busy... in the meantime I've emailed the site she mentioned www.oreganol.com to ask whether they think oregano oil could help with my dad's cough.I told him about 'cod' and he's going to take it. What dose do you think? I told him your wonderful story about your grandfather, too and showed him the picture of his village. It's a little bit amazing how this fish swims his way through your family history!A question about curcumin. The April 2007 paper you sent says the delivery method is being investigated via nanotechnology and this probably won't be in time for my dad. I'm wondering whether non-orthodox medicine has - sometime, somewhere - found a delivery method which works. I'm going to find some herbalists here to ask about this. Do you have any thoughts...?janetah