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Many psychoactive drugs are either agonists (bind to receptor site to activate), antagonists (bind to receptor site without activation [block]) or allosteric modulators (bind to some other part of the receptor thereby changing the ability of the receptor to bind signalling molecules, or changing how much of an activating or deactivating effect there is when binding does happen).Psychedelics like psilocin that bind to 5-HT2A receptors are serotonin agonists, but one of the prevailing theories on mechanism of action is that this is only the first part of a cascade of effects throughout the brain, ultimately decreasing effecting a GABAergic system that modulates the "echos" in the brain waves (not the best description, I know). Effectively, this does exactly what you are proposing: it increases the number of neurons that are talking to each other, and how much they are saying (but that doesn't mean that any of this information is meaningful). This mechanism has also been implicated in dream states and hallucinations induced by seizures.I don't think there are any hormones or drugs that are antagonists to all the receptor in the brain, but even then, that would be terrible. Serotonin and dopamine are required for proper brain function, no neurotransmitters = no brain function. There are multiple receptors for each neurotransmitters, and each with their own function. As I mentioned before, psychedelic states can be induced either by enhancing some serotonin signalling pathways, or by inhibiting other pathways. Essentially changing the balance in any way leads to changes in brain function (though only some select changes are considered psychedelic)I do think that it could be very interesting to study how drugs interact with memory. For instance, there are many commonly used diazapene-based drugs that are allosteric modulators of certain GABA pathways. All potentiating diazapenes cause varying amounts of relaxation, euphoria, dizziness, amnesia and sleepiness. There are a few that are particularly noted for their effect on memory formation (Midazolam, for instance). There are other drugs that have been found to increase the ability of people to remember things that happen while on the drug (especially when in the same intoxicated state). I do think this offers a tool to investigate the mechanisms of memory formation and recall on a chemical basis...