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The levodopa from m.pruiens can cross the blood brain barrier, but apparently most of it converts to dopamine before it reaches the brain and dopamine isn't good to have in your body in higher than normal amounts since it increases heart rate(I've experienced this) and I think has some other bad effects. I did seem to get a barely noticeable cognitive boost, but now I think it's probably not worth it due to the increased heart rate. The thing that took me by surprise is that the increased heart rate took a week or so after supplementation to show up. Quite a delayed effect.So I'm guessing it would be safer to supplement tyrosine + NADH or L-phenylalanine. Patients with parkinson's are given a decarboxylase inhibitor known as carbidopa with levodopa to prevent it from being converted to dopamine before entering the brain, but it is only available by prescription and probably has some nasty side effects. I read somewhere that green tea and coffee contain small amounts of a weak decarboxylase inhibitor which is why some say it is better to take m.pruriens with green tea, but I'm having trouble verifying that now. This topic is somewhat discussed at the following link: http://www.longecity.org/forum/topic/23668-boosting-dopamine-tyrosine-dlpa-or-mucuna-pruriens/ [nofollow]
Quote from: urano75 on 23/03/2013 11:43:33So my two big questions currently are:1- Why is my immune system so easily weakened to give way to viral infections almost every week, either from dormant viruses or new ones?2- Why does sex seem to be a constant trigger for this condition?I had similar experiences when I was younger and did not know methyl-guard, vitamin-D etc.My hypothesis for your question 1 is that immune systems are weakened by too much histamine and too much mast cell activity, triggered by an orgasm. And that can be addressed with methylfolate,methylB-12 if you are an undermethylator.
So my two big questions currently are:1- Why is my immune system so easily weakened to give way to viral infections almost every week, either from dormant viruses or new ones?2- Why does sex seem to be a constant trigger for this condition?
Traditional Chinese medicine is an empirical medicine, meaning its underlying theory is often very flawed and unreliable, and unverifiable, even though some of the treatment it provides may alleviate some symptoms sometimes. The theory behind Jing and the vital energy in kidneys is a quintessential example of such flawed theory, in my view.Quote from: urano75 on 23/03/2013 16:41:09I think I stumbled upon sites like this before. Apart from the specific page on neurotransmitters, if you surf the rest of the site you'll see that essentially it considers regular orgasm and ejaculation an unhealthy habit.I've also read books about Taoist Sex (I regularly practice tai chi chuan) which support this position: semen should be preserved as much as possible, and semen retention techniques might help with it. They mention that loss of vital fluids weakens the brain (cognitive) and the joints (knees, spine) among other things. Traditional Chinese Medicine considers sexual-related issues coming from the depletion ofjing, a vital force stored in kidneys (see correspondence to adrenals in our medicine).
I think I stumbled upon sites like this before. Apart from the specific page on neurotransmitters, if you surf the rest of the site you'll see that essentially it considers regular orgasm and ejaculation an unhealthy habit.I've also read books about Taoist Sex (I regularly practice tai chi chuan) which support this position: semen should be preserved as much as possible, and semen retention techniques might help with it. They mention that loss of vital fluids weakens the brain (cognitive) and the joints (knees, spine) among other things. Traditional Chinese Medicine considers sexual-related issues coming from the depletion ofjing, a vital force stored in kidneys (see correspondence to adrenals in our medicine).
Quote from: Vincent M on 23/03/2013 19:15:07The levodopa from m.pruiens can cross the blood brain barrier, but apparently most of it converts to dopamine before it reaches the brain and dopamine isn't good to have in your body in higher than normal amounts since it increases heart rate(I've experienced this) and I think has some other bad effects. I did seem to get a barely noticeable cognitive boost, but now I think it's probably not worth it due to the increased heart rate. The thing that took me by surprise is that the increased heart rate took a week or so after supplementation to show up. Quite a delayed effect.So I'm guessing it would be safer to supplement tyrosine + NADH or L-phenylalanine. Patients with parkinson's are given a decarboxylase inhibitor known as carbidopa with levodopa to prevent it from being converted to dopamine before entering the brain, but it is only available by prescription and probably has some nasty side effects. I read somewhere that green tea and coffee contain small amounts of a weak decarboxylase inhibitor which is why some say it is better to take m.pruriens with green tea, but I'm having trouble verifying that now. This topic is somewhat discussed at the following link: http://www.longecity.org/forum/topic/23668-boosting-dopamine-tyrosine-dlpa-or-mucuna-pruriens/I agree with everything you said here, about the side effect of L-DOPA, and on NADH+tyrosine. I think NADH boost BH4 levels, which promote the process of phenylalanine->Tyrosine->L-DOPA in the brain. I do think tyrosine is superior to phenylalanine, because it will only consume 1 BH4 molecule to get L_DOPA, while 1 phenylalanine molecule will consume 2 BH4. And in the US and Europe, we probably already have too much phenylalanine in our diet, due to the wide use of aspartame, as in Diet-coke.
The levodopa from m.pruiens can cross the blood brain barrier, but apparently most of it converts to dopamine before it reaches the brain and dopamine isn't good to have in your body in higher than normal amounts since it increases heart rate(I've experienced this) and I think has some other bad effects. I did seem to get a barely noticeable cognitive boost, but now I think it's probably not worth it due to the increased heart rate. The thing that took me by surprise is that the increased heart rate took a week or so after supplementation to show up. Quite a delayed effect.So I'm guessing it would be safer to supplement tyrosine + NADH or L-phenylalanine. Patients with parkinson's are given a decarboxylase inhibitor known as carbidopa with levodopa to prevent it from being converted to dopamine before entering the brain, but it is only available by prescription and probably has some nasty side effects. I read somewhere that green tea and coffee contain small amounts of a weak decarboxylase inhibitor which is why some say it is better to take m.pruriens with green tea, but I'm having trouble verifying that now. This topic is somewhat discussed at the following link: http://www.longecity.org/forum/topic/23668-boosting-dopamine-tyrosine-dlpa-or-mucuna-pruriens/
Maybe. I've used acupuncture for the last 2 years. Not sure how much it's been effective, with all the things I'm doing.
Quote from: urano75 on 23/03/2013 21:28:35Maybe. I've used acupuncture for the last 2 years. Not sure how much it's been effective, with all the things I'm doing.Acupuncture might be an unnecessary risk. Seems overall the evidence is inconclusive. Also I heard about this in the news: "A court in Switzerland has found a self-styled acupuncturist guilty of intentionally infecting 16 people with HIV, the virus that causes AIDS."http://www.centredaily.com/2013/03/22/3549501/swiss-acupuncturist-convicted.htmlThis is a rare example, but still something to consider.
The dopamine depletion theory seems like an obvious (read good) avenue to explore.
How well (no pun) did the bupropion help you? Did you feel as good as you did when you tried the testosterone? (because I remember you were super excited, even though your good results were only short-lived sadly)
when you're used to feeling 20%, feeling 70% is awesome and gives you a ton of hope.
Quote from: LAPOISSE2 on 22/03/2013 17:28:38Hi, There is hope; It's funny, I was just writing about dopamine in the other forum ; bellow is my though of the day thats are linked to yoursThis research is amazing : http://www.reuniting.info/science/articles/acute_dopamine_depletion_causes_psychological_distressDid not find a better match with POIS ; fatigue, anxiety, social disorder and cognitive impairment that come and goes back within days ;Orgasm = Dopamine VS prolactin ; What if prolactin wins by KO because raise for 1 hour only(non detectable) to the sky ? How long would dopamine need to go back to it's initial level ?My prolactin like others is high, we had several hyperprolactinemia here(even adenoma)Junk food cause low dopamine, stress cause low dopamine(see the vicious circle here), SSRI are also involved in dopamine reuptake inhibition, work for while and make symtoms worse(my story), coffe also.Dopamine and testosterone are friends ; both high are both lowIs anybody tried to boost dopamine : soft way is mucuna pruriens / less soft ways are levodopa are dopamine agonist like bromocriptine(Coreeman tried that apparently but kinda disappeared from the forum then) ?The theory is not new in here : https://sites.google.com/site/poiswebsite/test-page/orgasm-induced-catecholamine-imbalance-via-pituitary-dysfunctionThe levodopa from m.pruiens can cross the blood brain barrier, but apparently most of it converts to dopamine before it reaches the brain and dopamine isn't good to have in your body in higher than normal amounts since it increases heart rate(I've experienced this) and I think has some other bad effects. I did seem to get a barely noticeable cognitive boost, but now I think it's probably not worth it due to the increased heart rate. The thing that took me by surprise is that the increased heart rate took a week or so after supplementation to show up. Quite a delayed effect.So I'm guessing it would be safer to supplement tyrosine + NADH or L-phenylalanine. Patients with parkinson's are given a decarboxylase inhibitor known as carbidopa with levodopa to prevent it from being converted to dopamine before entering the brain, but it is only available by prescription and probably has some nasty side effects. I read somewhere that green tea and coffee contain small amounts of a weak decarboxylase inhibitor which is why some say it is better to take m.pruriens with green tea, but I'm having trouble verifying that now. This topic is somewhat discussed at the following link: http://www.longecity.org/forum/topic/23668-boosting-dopamine-tyrosine-dlpa-or-mucuna-pruriens/
Hi, There is hope; It's funny, I was just writing about dopamine in the other forum ; bellow is my though of the day thats are linked to yoursThis research is amazing : http://www.reuniting.info/science/articles/acute_dopamine_depletion_causes_psychological_distressDid not find a better match with POIS ; fatigue, anxiety, social disorder and cognitive impairment that come and goes back within days ;Orgasm = Dopamine VS prolactin ; What if prolactin wins by KO because raise for 1 hour only(non detectable) to the sky ? How long would dopamine need to go back to it's initial level ?My prolactin like others is high, we had several hyperprolactinemia here(even adenoma)Junk food cause low dopamine, stress cause low dopamine(see the vicious circle here), SSRI are also involved in dopamine reuptake inhibition, work for while and make symtoms worse(my story), coffe also.Dopamine and testosterone are friends ; both high are both lowIs anybody tried to boost dopamine : soft way is mucuna pruriens / less soft ways are levodopa are dopamine agonist like bromocriptine(Coreeman tried that apparently but kinda disappeared from the forum then) ?The theory is not new in here : https://sites.google.com/site/poiswebsite/test-page/orgasm-induced-catecholamine-imbalance-via-pituitary-dysfunction