Naked Science Forum
Life Sciences => Physiology & Medicine => Topic started by: smart on 28/06/2016 13:04:30
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Traumatic brain injury (TBI) prognosis is not well characterized. Could gene therapy offers a prospective treatment for neurological injuries ?
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Traumatic brain injury (TBI) prognosis is not well characterized. Could gene therapy offers a prospective treatment for neurological injuries ?
Most studies suggest that once brain cells are destroyed or damaged, for the most part, they do not regenerate. However, recovery after brain injury can take place, especially in younger people, as, in some cases, other areas of the brain make up for the injured tissue.
In other cases, the brain learns to reroute information and function around the damaged areas. The exact amount of recovery is not predictable at the time of injury and may be unknown for months or even years. Each brain injury and rate of recovery is unique. Recovery from a severe brain injury often involves a prolonged or lifelong process of treatment and rehabilitation.
Alan
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There's some interesting and promising work with neural stem cells. Basically stem cells were injected into the brain and the brain starts growing back in mice. Look up Revita Life Sciences and Bioquark Inc. reanimation project.
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A new study developed a method to deliver siRNA cargo to neurons using synthetic nucleic acids. Why is TBI a model to develop neurons-targeting nanotechnology?
https://www.ncbi.nlm.nih.gov/pubmed/27429164
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Why is TBI a model to develop neuron-targeting nanotechnology?
https://www.ncbi.nlm.nih.gov/pubmed/27429164
I'm not sure I understand the question, but in order to effectively treat TBI's with the nucleic acids in question, they need to have a way to get them to permeate the BBB.
Effective BBB-permeation is the primary reason they developed drug-targeting nanotechnology.
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... Bioquark Inc ...
Any medical company who puts "quark" in their name should be viewed with the utmost skepticism (http://rationalwiki.org/wiki/Quantum_woo#Pseudoscience).
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... Bioquark Inc ...
Any medical company who puts "quark" in their name should be viewed with the utmost skepticism (http://rationalwiki.org/wiki/Quantum_woo#Pseudoscience).
Huh?
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Huh?
When sellers use terms from quantum-mechanics, like quark (https://en.wikipedia.org/wiki/Quark), which have no relevance to their product, they are trying to blind people with science. A hallmark of a scam.
The BioQuark laboratory looks impressive ... http://www.bioquark.com/about-us/
But it's just a stock-photo ... http://www.shutterstock.com/pic-93620779/stock-photo-hand-in-rubber-glove-holding-a-bottle-of-medicine-against-the-background-of-the-production-line-drugs.html?src=1h0HOoG2qyeswn2RqwBnYg-1-29
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So what's the "scam" again? Confused.
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So what's the "scam" again? Confused.
If the sales-spiel on a product unnecessarily includes quantum-mechanics terms, then they are trying to obfuscate matters. Either because the product/service they are selling doesn't work at all , or it's a bog-standard product which they are charging a premium-price for.
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So what's the "scam" again? Confused.
If the sales-spiel on a product unnecessarily includes quantum-mechanics terms, then they are trying to obfuscate matters. Either because the product/service they are selling doesn't work at all , or it's a bog-standard product which they are charging a premium-price for.
So then is the implication that the findings/claims made in this abstract are false as a result?
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So then is the implication that the findings/claims made in this abstract are false as a result?
We may be at cross purposes. I'm talking about "BioQuark Inc" mentioned in this thread, [Reply #2].
Subatomic particles, like quarks, have no relevance to their allegedly regenerative biologic product.
If any sales-spiel shoehorns-in irrelevant quantum mechanics terms, either the product does not work , or is overpriced.
"BioQuark Inc" seem to be claiming their products can enable body parts to be regenerated.
That's unbelievable.
All the photos on their website of laboratories & scientists are stock-photos,
as would be the case if they didn't actually have a lab or scientists.
On this BioQuark page ... http://www.bioquark.com/therapeutic-programs/bq-a/
it says "... living human egg ... Bioquark is the first company that has taken the step to export this biochemical regulatory architecture to somatic tissue in mammals",
but the image shown on that page is a stock-photo of worm eggs. Not human, not mammal.
I'm not being unduly skeptical to say BioQuark has scam written all over it, not just it's quantum-woo (http://rationalwiki.org/wiki/Quantum_woo) name.
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For the record, my responses thus far merely pertain to the following comment & link:
"A new study developed a method to deliver siRNA cargo to neurons using synthetic nucleic acids. Why is TBI a model to develop neurons-targeting nanotechnology?" https://www.ncbi.nlm.nih.gov/pubmed/27429164
Does this ACS Nano study somehow relate to BioQuark?
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Does this DARPA-sponsored research on permeating the BBB with synthetic nucleic acids can be used to deliver drugs to people not affected by traumatic brain injury? Or is the BBB damaged in the case of TBI, allowing nanoparticles access to neurons?
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Does this ACS Nano study somehow relate to BioQuark?
No. But you quoted my post about "BioQuark Inc" in Reply #6 in this thread. The confusion is entirely on your part.
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Does this DARPA-sponsored research on permeating the BBB with synthetic nucleic acids can be used to deliver drugs to people not affected by traumatic brain injury?
No. The DARPA research primarily pertains to battlefield-related ballistic injuries.
Or is the BBB damaged in the case of TBI, allowing nanoparticles access to neurons?
An increase in paracellular permeability and opening of the tight junctions following TBI, allows nanoparticulate agents ect, to permeate the BBB.
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I had a TBI 10 years ago.Any re-organization of my brain to bypass damaged areas has mostly taken place.A continuing effort to adapt to deficits in former abilities by using new strategies is ongoing and lifelong.There are certain physical disabilities as well as mental.since the brain controls both.I am unable to perceive some problems,and depend somewhat upon the observations of others.I have noticed a definite shift in my thinking and behavior based on my memories of my former life.I have come to realize that once a neuron is destroyed,its memory or function is destroyed as well.Replacing large numbers of destroyed neurons will provide an area of the brain which must be re-set,so to speak,and which will not contain the original personality or knowledge which was formerly contained.Hence,the person is at least slightly different,and not merely"repaired."-My personal opinion,based on personal experience.Live with it,and make the best of it.It's not all bad.