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Hi,If methylation might be related to pois - could it then all be related to mthfr-mutation?The mthfr gene.. Can mehylfolate and methylcobalamin work?
Hey guys. Just want to post my story to add more to the database. (I wrote the first part of this post in November I believe)I have been dealing with POIS since I was 17 years old, getting worse every year, and now I am 23. I have tried many medications with limited success. Symptoms-Brain fog-Anxiety, social anxiety-Fatigue-Eyes hurt-Loss of motivation, mild depression-Pain-Loss of appetiteI have a history of moderate drug use. First was marijuana when I was 15-18 years old on and off. I had my first panic attack from it and got anxiety for the first time in my life which got better but never went away to how it was before.I used adderal on and off as well, sometimes using high doses very occasionally. I have since not used any alcohol or drugs in 4+ years besides marijuana which I also quit 6 months ago after using for a short period again. In this period it seemed marijuana used before orgasm would help the POIS.I have done a lot of blood tests, as well as a mineral hair analysis. I will post them all below. I have two sets of thyroid labs. The first - 3 months ago, the second - a few weeks ago after taking 75 mcg T4 for a month. Iron, ferritin and ceruloplasmin about 10 months ago. I'll check it all again in a month or two. I take zinc picolinate 45 mg, sodium-copper-chlorophyllin 12 mg, 100 mcg tocotrienols, lithium orotate 5 mg, vitamin K2 mk7 100 mcg. Ceruloplasmin 20 (18-36 mg / dL)Ferritin 46 (20-345ng / mL) Iron 80 (50-195mcg / dL) TSH 13.94 (0.40-4.50mIu / L) Free T4 0.8 (0.77-1.50ng / dL) TSH 1.652 (0.360- 5.490microInter.Units / mL) Free T4 1.12 (0.77-1.50ng / dL) SODIUM 139 135-146 mmol / L POTASSIUM 4.4 3.5-5.3 mmol / L CALCIUM 9.7 8.6-10.3 mg / dL CHLORIDE 103 98-110 mmol / L Magnesium 2.1 (1.5-2.5mg / dL) Vitamin B12 845 (211-911pg / mL) Folate 6 (0.9-15.6ng / mL) Vitamin D 35 (30-100ng / mL) Testosterone 542 (300-1080ng / dL ) Zinc 85 (60-120mcg / dL) Copper 67 (70-140mcg / dL) WBC 3.8 (4.5-11.0x10'3 / microL) RBC 5.52 (4.20-6.10x10'3 / microL) HGB 16.4 (11.6-17.6g / dL)Platelet 143 (125-400x10'3 / microL) MPV 12.6 (9.3-12.0fL) Glucose 93 (65-99mg / dL) These tests from 5 months ago Estrone 31 ( Prolactin 11 (2-18ng / mL) Estradiol 20 <OR = 39pg / mL) Progesterone 0.5 (<1.4ng / mL) Ferritin 46 (20-345ng / mL) Iron 80 (50-195mcg / dL) TIBC 330 (250-425mcg / dL) % Saturation 24 (15-80%) Selenium 112 (63-160 mcg / L) RBC Magnesium 5.6 (4.0-6.4 mg / dL) Ca / Mg ratio- 9.16, NA / K- 1.73, Zn / Cu 20.9, Ca / K 25.82, Na / Mg 0.61, Fe / Cu 0.52.Hypothyroidism, low cortisol, low testosterone (fixed, taking zinc picolinate 45 mg per month. Low zinc levels (fixed with zinc) Low copper levels, low ceruloplasmin, very high levels of arsenic on HTMA, iron levels are quite good. A few things to note. I have a very strong libido, even when my testosterone was very low. I also have a very difficult time refraining from porn. POIS worse from porn + masturbation vs. sex. It seems that I have a dopamine problem, because I am always craving things like junk food, sugar, porn, etc. When I watch porn even without orgasm, my body starts to shiver and I get cold and shaky. Which would lead me to think an adrenal problem.I have not eaten corn gluten corn or soy for 4 years, as a result of which my antibodies to Hashimoto reached normal levels. I refrained from porn / masturbation for 4 months of this year, in which I felt much better, but not 100%. I was still having sex during that time. I am going to do more blood tests in about a month and later on a mineral hair analysis.Update as of December-I got a blood test again and here are the results. Aldosterone was EXTREMELY low. And the reverse t3 is high. Based on these results, I'm going to reduce sodium intake and raise potassium, and also take licorice root to raise aldosterone. Also try DHEA. This is after taking 75 mcg T4 and 15 mcg T3 during the month. Also chlorophyll for copper (6-8 mg per day). I will work up to 25mcg to T3. I'm going to stop the t4 for a bit and use only t3 lower reverse t3, and then try to add in a small dose of t4 again.Aldosterone <1 ng / dL of ACTH 18 (6-50pg / mL) of Cortisol 10.9 (4.0-22.0mcg / dL) the Free t3 4.3 (2.3-4.2pg / mL) the Free t4 1.4 (0.8-1.8 ng / dL) Reverse t3 22 (8-25ng / dL) Ferritin 127 (20-345ng / mL) Prolactin 7.9 (2-18ng / mL) Testosterone 500 (250-827ng / dL)TSH 0.05 (0.4-4.5mIU / L) Estradiol 16 (<OR = 39pg / mL) Vitamin D, 25-OH 53 (30-100ng / mL) Vitamin D, 1.25 (OH) 2 36 (18-72pg / mL)My theory for why I have POIS is a mix of the following:-Adrenal fatigue-Hypothyroidism-Low dopamine and serotonin (Low serotonin= high sex drive) from drug useHopefully this post helps someone else with similar issues. I will keep updating