Naked Science Forum
Life Sciences => Physiology & Medicine => Topic started by: thedoc on 02/10/2013 04:30:02
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Justin Chamblee asked the Naked Scientists:
I'm not sure if you could offer any advice to me. A few months back I was diagnosed by a Urologist as having Peyronies disease. I'm not sure how I would have developed this condition as I have had absolutely no sexual partners for the last 10 years or so and have not injured myself (down there) at all.
It just seems that since about March this year I suffer from sore and painful erections. The Urologist prescribed Colchicine and Vtamin E tablets to take (one of each) daily. Sadly for me the medication does not appear to be working & my condition with sore erections only seems to have worsened.
Do you think Peyronies disease could be related to sugar diabetes or high blood pressure? I am 42 years of age and when last having had a medical check up I was only diagnosed with slightly high blood pressure. The Urologist told me that Colchicine is a medication used to treat Gout. I do enjoy a glass or two of red wine in the evenings after work. Could red wine perhaps be linked to this Peyronies problem I have.
I am due to see the Urologist again in the next 4 months or so. Needless to say I am quite worried whether this condition I have can be reversed or whether it will only worsen and what alternative treatments might be available.
Thanking you for any professional advice you may offer.
I enjoy listening to your radio show on Talk radio 702 here in Johannesburg.
Kind regards,
Justin
What do you think?
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Diabetes is strongly associated* with vasculopathic disease ...
Diabetes is a disease that is strongly associated with both microvascular and macrovascular complications, including retinopathy, nephropathy, and neuropathy (microvascular) and ischemic heart disease, peripheral vascular disease, and cerebrovascular disease (macrovascular), resulting in organ and tissue damage in approximately one third to one half of people with diabetes
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579903/
Vasculopathy reduces the blood supply to parts of the body so can result in sclerosis and high blood-pressure.
[* "strong association" does not tell you cause from effect ]
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Hi,
Peyronies disease is not related to high blood pressure. Well if you have peyronies disease then the matter is different. For that, you have to cure it as in this disease, your penis becomes curved, your penis size diminishes, you will face unocmfortable to do sex and also it will be very painful. However you should use some ways like use of peyronies device which can help you to straighten your curved penis size and also increase your size of penis.
http://www.mensexualclinic.com/peyronies-disease-how-to-cure-curvature-of-penis
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It behooves me as an RN (California License # 259063) to point out that the Naked Scientists allow any total quack to come in here and victimize readers with references to some dodgy web "Mens Sexual Clinic. com".
About 8-12 % of Peyronie's patients resolve on their own after a few months.[1.]
Furthermore...
In 2004, Safarinejad showed that colchicine, an antigout agent that inhibits fibrosis and collagen deposition by inhibiting neutrophil microtubules, did not have a more beneficial effect than placebo on patients suffering from PD [ncbi, op cit]
Which news may not have reached South Africa yet..
But
Medication
The goals of treatment with medication include reducing plaque formation and pain, as well as minimizing curvature of the penis.
There is one medication approved by the Food and Drug Administration for the treatment of Peyronie's disease. It's called collagenase Clostridium histolyticum (Xiaflex). This medicine is approved for use in men with a palpable lump from plaque in the penis that causes a curvature of at least 30 degrees during erection.
The treatment works by breaking down the buildup of collagen that causes penile curvature. It involves a series of in-office injections, directly into the penile lump, as well as penile modeling — brief exercises to gently stretch and straighten the penis.
In clinical trials, this collagenase therapy significantly reduced curvature and bothersome symptoms associated with Peyronie's disease in many participants. Discuss potential side effects of this medication with your doctor, as some of them can be serious.
Examples of off-label use of medications for Peyronie's disease include an oral medication called pentoxifylline (Trental), verapamil (injections or topical gel) and interferon (injections). [2.]
In any case, you should worry more about ( and aggressively treat) your "minimal" hypertension, because the shape of your penis won't matter much if you must wear diapers after a stroke. That goes double for diabetes. The sexual life of patients on kidney dialysis is only rarely to be admired.
Speaking of sex, you may find the support forum at The Peyronies Disease Society helpful. The last time I had a look-in they seemed to be fascinated with the number "69" for some reason.
http://www.peyroniessociety.org/
[1.]http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3221554/
[2.]http://www.mayoclinic.org/diseases-conditions/peyronies-disease/basics/treatment/con-20028765