Naked Science Forum

Life Sciences => Cells, Microbes & Viruses => Topic started by: mneuro on 03/04/2018 14:19:04

Title: What is the expression of various neurotransmitter receptors in the brain
Post by: mneuro on 03/04/2018 14:19:04

Specifically, do some regions of the brain have higher dopamine receptors while others have more serotonin receptors? If, so if there a map that shows these concentrations?

Title: Re: What is the expression of various neurotransmitter receptors in the brain
Post by: chiralSPO on 03/04/2018 16:34:43

My understanding is that neurons each have many different types of receptors (and they interact with each other in very complex ways). But there are definitely parts of the central nervous system that have higher concentrations of certain types of receptors. For instance, 5-HT_2A receptors (serotonin) are concentrated in the prefrontal cortex and dorsal raphe nucleus, and the neurons that contain them appear to regulate nearby GABA-ergic neurons (last I read up on these things, which was about a decade ago, so the current understanding might be different now)

Title: Re: What is the expression of various neurotransmitter receptors in the brain
Post by: mneuro on 03/04/2018 18:02:35

Yea I'm mainly interested in the cortex. I haven't found anything that does a good comparative analysis of the various receptor types between the different regions of the cortex. Brodmann divided it up with cytoarchitectonics but I can't find anything in great detail about relative receptor expression in each area. I wonder if it varies from person to person.