Naked Science Forum

Life Sciences => Physiology & Medicine => COVID-19 => Topic started by: Peter Dow on 09/04/2020 21:10:14

Title: Could a clot-busting drug help save the lives of patients on ventilators?
Post by: Peter Dow on 09/04/2020 21:10:14

Asking for a friend.

COVID-19: Could a clot-busting drug help save the lives of patients on ventilators? (https://www.medicalnewstoday.com/articles/covid-19-could-a-clot-busting-drug-help-save-the-lives-of-patients-on-ventilators)
Medical News Today, Written by James Kingsland on April 9, 2020 - Fact checked by Hilary Guite, FFPH, MRCGP

reporting in layman's language on this -

Is There a Role for Tissue Plasminogen Activator (tPA) as a Novel Treatment for Refractory COVID-19 Associated Acute Respiratory Distress Syndrome (ARDS)? (https://journals.lww.com/jtrauma/Citation/publishahead/Is_There_a_Role_for_Tissue_Plasminogen_Activator.97967.aspx)
Special Report. Journal of Trauma and Acute Care Surgery: March 20, 2020 - Volume Publish Ahead of Print - Issue -
doi: 10.1097/TA.0000000000002694

Quote

"we believe an initial approach might be to administer 25mg of tPA over 2 hours followed by a 25mg tPA infusion administered over the subsequent 22 hours, with a dose not to exceed 0.9 mg/kg."

Hmm, if I am admitted to hospital suffering from COVID-19 and struggling even with oxygen therapy, I think I'd sooner try tissue plasminogen activator (https://en.wikipedia.org/wiki/Tissue_plasminogen_activator) BEFORE they put me on a ventilator, to see if it helps me breathe more easily.

CBS TV news video: Deathly Ill Coronavirus Patients Could Be Saved By Heart Attack And Stroke Drug (https://cbsloc.al/2VeU7BO)