Naked Science Forum
Life Sciences => Cells, Microbes & Viruses => Topic started by: Lewis Thomson on 27/01/2022 10:26:23
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Donald would like help finding answers to this question.
"Most humans for most of our lives have been multicellular organisms. What holds our cells together. There has to be some glue between these individual cells or we would fall apart into a heap of unorganized cells. And then, what stops circulating cells from becoming stuck, like white blood cells and macrophages?"
Leave your thoughts in the comments below...
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Cell adhesion is the process by which cells interact and attach to neighbouring cells through specialised molecules of the cell surface. Cell adhesion occurs from the interactions between cell-adhesion molecules (CAMs),[2] transmembrane proteins located on the cell surface.
There are many different types of CAMs on different tissues.
White blood cells also have some CAMs, which allow them to patrol blood vessels and enter various tissues in pursuit of pathogens.
https://en.wikipedia.org/wiki/Cell_adhesion
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Our organs are lined with a protective covering of epithelial cells. Many recent studies have confirmed that these epithelial cells act as a barrier and are tightened by the sealed molecular junctions. One of the key building blocks of these molecular junctions is a family of proteins, identified to be as "ZO" proteins. Technological advancements have confirmed that these ZO proteins stick to each other forming condensation droplets on the membrane of epithelial cells, to further sequester adhesion proteins and cell adhesion molecules to form tight junctions.
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