Naked Science Forum

Life Sciences => Physiology & Medicine => Topic started by: Shaun Tinkler on 11/12/2016 20:58:42

Title: Does receptor activation lead to an increase in mRNA expression of that receptor
Post by: Shaun Tinkler on 11/12/2016 20:58:42
My research project is about the effect of γ-Hydroxybutyric acid (GHB) on 5-HT2 (A and C) receptor mRNA expression, but I'm finding the whole thing confusing. First and foremost, once the 5-HT2A and 5-HT2C receptors have been activated by subsequent agonists, would this lead to an increase in mRNA expression? Would the activation lead to the increase?

Thanks
Title: Re: Does receptor activation lead to an increase in mRNA expression of that receptor
Post by: tkadm30 on 17/12/2016 11:23:31
Receptor activation induces downstream mRNA expression of secondary messengers via signal transduction.

See:

Neuromolecular Med. 2002;1(3):197-205.
5-HT2A receptor activation leads to increased BDNF mRNA expression in C6 glioma cells.
Meller R1, Babity JM, Grahame-Smith DG.
https://www.ncbi.nlm.nih.gov/pubmed/12095161