Naked Science Forum

On the Lighter Side => That CAN'T be true! => Topic started by: chris on 15/04/2017 09:20:50

Title: Can blood group A positive and O negative parents have a B negative child?
Post by: chris on 15/04/2017 09:20:50
Trinity got in touch yesterday to ask:

I am O- my husband is A+ so far our children are B- and O- is this normal? I didn't think we could have a B?

What do you all think?
Title: Re: Can blood group A positive and O negative parents have a B negative child?
Post by: evan_au on 15/04/2017 13:32:49
Patterns of ABO blood type inheritance are shown here (the lower phenotype table is easier to read):
https://en.wikipedia.org/wiki/ABO_blood_group_system#Genetics

You can't inherit a B unless at least one of the parents has a B or AB blood type.
There have been some cases caused by chimerism (https://en.wikipedia.org/wiki/Chimera_(genetics)#Humans),   but most cases have a more straightforward explanation.
Title: Re: Can blood group A positive and O negative parents have a B negative child?
Post by: Monox D. I-Fly on 14/10/2019 04:37:56
So, is the B one not her husband's biological child?
Title: Re: Can blood group A positive and O negative parents have a B negative child?
Post by: hamdani yusuf on 14/10/2019 07:52:08
So, is the B one not her husband's biological child?
Most likely. Unless the child get novel mutation.
More reliable conclusion needs more complete genetic analysis to compare gene loci between the child and the husband.