1

Physics, Astronomy & Cosmology / Re: What will the Event Horizon Telescope reveal?

« on: 15/04/2019 19:27:14 »

Here's the special podcast featuring Cambridge University's Carolin Crawford, from the Institute of Astronomy, updating the details of the EHT findings and answering some of the questions raised here on the forum

https://www.thenakedscientists.com/podcasts/short/eht-sheds-light-m87-black-hole

2

Chemistry / Re: If i dry-distil sodium acetate, will i get acetone?

« on: 23/02/2019 09:43:29 »

No, that won't work.

You're right that reacting baking soda (sodium biocarbonate - NaHCO₃) with acetic (ethanoic) acid - (CH₃CHOOH) will produce sodium acetate NaCH₃COO, which is the stuff used to flavour salt and vinegar crisps.

But acetate is in oxidised form and you would need to reduce it to produce the ketone (acetone).

I did see one claim that if you hear acetate salts to a reasonably high temperature (over 400C) and condense the vapour you'll get acetone. I cannot corroborate this though, and I've not fact-checked the claim.

Calling all chemists! Is this right, and what's the mechanism?

3

Physics, Astronomy & Cosmology / Re: What is the difference between astronomy and cosmology?

« on: 20/01/2019 12:44:56 »

Okay, I'll give this a go:

Astronomy is an observation-based discipline that looks at the Universe and uses various tools to make measurements which may, in turn, inform, support or refute predictions made by theoreticians including cosmologists. The latter are physicists who uses models, maths and observations to build an understanding of how the Universe behaves.

4

Just Chat! / Re: Latest Forum Updates and Upgrades

« on: 16/01/2019 23:36:38 »

HAPPY NEW YEAR - First Update of 2019

Hello everyone; I hope you all had a very pleasant Christmas and New Year. This year I managed to avoid breaking the website over the holidays, which turned my holiday last year into a week of hell, which some of you might remember!

This is a brief note about a couple of updates and upgrades that we have made over December and the first part of this month:

1) Cookie consent opt-in

We've always been very clear in our privacy policy page regarding how we operate on this website, but to make this even more transparent we introduced an opt-in pop-up.

You'll see this appear at the bottom of the page as a black bar with a green button. This contains a link to the privacy page so that you can review how we operate, in case you need to refresh your knowledge.

You will only be required to opt-in once. As soon as you do so, the system remembers you (unless you clear your browser data or switch computers or to another browser platform) and will not pester you again.

2) Notifications of new Naked Scientists programmes and articles

We implemented a notification system that you may choose to sign up to; this will pop-up a small window in the bottom right of your screen when the Naked Scientists publish specific types of content including new radio programmes or podcasts and science feature articles.

The first time you visit the site in your browser you will see a small red bell icon at the bottom right of the screen. Clicking on this produces a menu that enables you to elect to sign up to our notifications, or block them.

If you do sign up, we promise that you will not be pestered by this system. We have purposefully set it up to flag up only a small amount of our best content. We anticipate that we will produce only one or two such pieces every day or two.

You may opt out of the system by selecting "block" at the time of sign-up, or by visiting your browser settings and applying a block against our notifications from there.

3) "Tags" has been fixed.

We have fixed a long-term bug in the tagging system. The box inviting you to "add some tags to your post" at the time when you first create a new thread was failing to create the tags that were entered.

This has now been resolved. We tracked down the error and have resolved it, so do please resume using this system.

Adding tags to your posts makes them far more visible on the site and via the tags menu, meaning that they will most likely garner greater visitor engagement.


Lastly, thanks everyone for your energy and contributions to the forum, especially the moderators, and helping us to create what is an amazing place to learn.

Best wishes for 2019!

Chris

5

Physiology & Medicine / Re: What could cause a too high potassium count?

« on: 08/01/2019 07:55:00 »

You have referred to the most common causes of hyperkalaemia (raised potassium). For clarity, these are:

Renal failure (acute or chronic)
Antihypertensive drugs (beta blockers, ACE inhibitors)
Diabetes
Excessive potassium ingestion

These are also other, rarer causes like adrenal insufficiency (Addison's disease) where the adrenal cortex fails to produce adequate mineralocorticoid (pro-sodium-elevating) steroids; this leads to hyponatraemia and hyperkalaemia.

Have all of these been excluded?

6

Just Chat! / HAPPY NEW YEAR 2019!

« on: 01/01/2019 09:32:48 »

My very best wishes to everyone; welcome to 2019; let's hope it's fun, prosperous and productive for us all!

What's everyone up to today?

7

Just Chat! / Merry Christmas!

« on: 25/12/2018 09:50:15 »

Happy Christmas everyone!

Just dropping by to wish everyone a very Merry Christmas; have a lovely day (evening for the Aussies among you who were already tucking into turkey, and in one case curry, as I was going to bed!).

BW

Chris

8

Physiology & Medicine / Re: If you feel well are you healthy?

« on: 01/12/2018 11:01:54 »

Part of the reason that we feel unwell when we are ill is because the immune response is releasing chemical signals called cytokines.

These circulate in the blood and provoke the symptoms of malaise that accompany illness, including fever, fatigue and aching muscles.

This means that, in general, the more pronounced the immune response the more severe the symptoms. And sometimes this can be maladaptive.

Indeed, in some of the patients I've treated in the past, giving them steroids to damp down the immune response has been helpful in mitigating their symptoms.

An example of this is the treatment of bacterial meningitis: when antibiotics are given, the dying bacteria release inflammatory debris that can provoke a very profound inflammatory reaction which can be destructive in its own right.

By blunting that response temporarily, you can improve the clinical outcome. Scientists recently showed that aspirin given as an anti-inflammatory can also be very beneficial in the treatment of TB meningitis: https://www.thenakedscientists.com/articles/interviews/aspirin-tuberculous-meningitis

Notwithstanding the above, it's not true that a person with a weaker immune response will feel better when challenged by the same infection, because they will most likely ultimately develop a more severe, invasive disease, which will compromise them in other ways.

So, the bottom line is that feeling unwell is a side effect of an immune response. But the absence of an immune response is not a guarantee of a symptom-free illness experience...

9

Cells, Microbes & Viruses / Re: When to use italics in a write up?

« on: 29/11/2018 16:59:28 »

Species names in long, abbreviated and species / group name forms are traditionally italicised: e.g. Streptococcus sp. and Strep. pneumoniae

If you were saying "Streptococcal infection", you probably wouldn't italicise that.

10

Physiology & Medicine / Re: How can cortisol be managed to keep levels OK for health and pain relief?

« on: 28/11/2018 23:57:36 »

Hmm, but not all steroid molecules are made equal. Relative to cortisol some steroid preps are much more bioactive, meaning that they access and stimulate their targets much more powerfully. So although they suppress endogenous steroid production, what you replace it with is much more potent.

11

Physiology & Medicine / Re: How can cortisol be managed to keep levels OK for health and pain relief?

« on: 27/11/2018 18:19:34 »

Exogenous steroids (like prednisolone and dexamethasone) are best taken in the morning because this mirrors the natural steroid surge that accompanies waking. Regular use of an exogenous steroid will cause a reduction in the body's own steroid production, so topping up the morning surge is least disruptive to your circadian cycle. If you take the steroid later in the day then it provokes wakefulness and this can lead to disturbed sleep or insomnia.

12

Plant Sciences, Zoology & Evolution / Re: Why do most humans have traces of Neanderthal DNA?

« on: 27/11/2018 09:08:08 »

Both species definitely share ancestors, which is why our DNA is so similar in the first place, but Neanderthals and anatomically modern humans diverged from one another 200-300,000 years ago. Current thinking is that the last ancestor we both share is Homo erectus, which was spawned about 1.8 million years ago. Neanderthals disappeared about 30-40,000 years ago.

Because they are relatively recently extinct, Neanderthal remains are a good prospect for DNA recovery, and about 10 years ago scientists completed the Neanderthal genome project; this is the Neanderthal equivalent of the Human Genome Project that decoded all 3 billion letters of the human DNA code.

Armed with this sequence, and because we are so closely related, it's possible to align the Neanderthal DNA makeup with the modern human genome and to highlight areas that are shared and areas that are distinct.

Areas of the genome that are shared by both were inherited from an ancestor to both Neanderthals and us and will be universally present. Similarly, sequences that are specific to one species or the other - having evolved after the two species split - will be exclusively present in each species.

But there will also be regions of the genome that are variably shared in human and Neanderthal populations, indicating gene mixing. This is the example you highlight of some human populations carrying Neanderthal sequences but not others. It is also the evidence that tells palaeontologists and geneticists that the two species interbred, which is how these gene sequences came to be variably shared.

13

Physics, Astronomy & Cosmology / Re: What are gravitons and how do they explain gravity?

« on: 17/11/2018 08:31:19 »

Hi @miniguy

There are a number of theories for how gravity "works"; the most popular -  and evidence-based - is Einstein's theory of general relativity, which proposes that mass deforms the fabric of the universe - Spacetime.

People talk about a bowling ball sitting in the centre of a trampoline to make a dent that causes other bodes to roll down into the "gravity well" created by the bowling ball; this is why massive bodies, like stars, cause moving bodies like planets to deviate from a straight trajectory and instead adopt an orbital path.

Meanwhile, quantum mechanics (QM) has investigated how gravity can be fitted into what we call the "standard model", which is the collection of particles and force carriers that make up matter in the Universe around us. This QM theoretical model invokes a particle as the force carrier to convey gravitational attraction. This notional particle is the graviton. So the idea would be that objects are attracted to one another by constantly giving away and receiving a stream of gravitons between them. And like photons, these notional particles would travel at the speed of light.

The problem is that no one has ever seen a graviton, and all the theories that have so far tried to merge what we do know about gravity with QM yield nonsense results. So, for now, gravitons remain a theory among theories.

14

Geology, Palaeontology & Archaeology / Re: What is this ridged fossil found in Somerset?

« on: 05/11/2018 08:11:31 »

PS @Sandmidj - I modified your post to insert the image into the body text so it's immediately visible. To do this yourself, if you need to, you go to "attachments" below the text box (where you uploaded the image in the first place) and click on the "insert" link next to the image name. You can do this at the time of uploading, no need to modify later. I think it helps because the image is presented at full size and people have less work to do to review the picture. chris

15

Geology, Palaeontology & Archaeology / Re: What is this ridged fossil found in Somerset?

« on: 05/11/2018 08:09:27 »

Could be bits of fossilised marine algae. I found some nice fossilised wood pieces in Teignmouth, Devon, a few years back; the appearance is quite similar.

16

Geology, Palaeontology & Archaeology / Re: What is this ridged fossil found in Somerset?

« on: 03/11/2018 22:29:22 »

The first thing I thought about were fossilised ripples, but, as I pointed out, there are ridges on both sides, which made me question my original instinct. I've seen quite a lot of examples of ripple patterns, especially in the rocks in NW Australia where I spent a bit of time, but none had ripples on both sides.

17

Geology, Palaeontology & Archaeology / Re: What is this ridged fossil found in Somerset?

« on: 03/11/2018 15:59:03 »

Interesting how the ridged profile is symmetrical on both sides of the specimen.

This needs @Bass to make a diagnosis. It's above my paygrade.

18

Chemistry / Re: Why is there an asterisk next to an author's name in a journal paper?

« on: 28/10/2018 13:52:04 »

Usually this refers to the "corresponding author" (i.e. the person to write to about the paper), or can sometimes be used when applied to two first authors to indicate that both made a equal contribution to the work.

To find out what the asterisk means refer to the author details legend below the list of names. In electronic publications this is usually a clickable option next to the author list. In print copy journals they usually put the legend somewhere on page 1.

19

Chemistry / Re: How do you make a mirror?

« on: 19/10/2018 05:11:47 »

I've used a similar approach to silver-coat the inside-surface of a round-bottomed flask in order to make a scientifically-inspired Christmas baubal. The ammonia solution is very strong and you need good ventilation.

I'm not sure what the tin chloride solution does and why you need that - anyone know?

20

That CAN'T be true! / Re: Do photons, neutrinos and dark matter have a structure?

« on: 15/10/2018 10:46:25 »

Er either I'm really jetlagged or none of this makes any sense whatsoever...