Hi guys, I have been suffering from the symptoms of POIS for my entire adult life (roughly 11 years). Symptoms include brain fog, difficulty maintaining erections, depression, fatigue, anxiety, swelling of eyes, paleness, premature ejaculation, lack of motivation...the list goes on.Dante: I received an intradermal test from Dr. Nguyen and Dr. Bewtra at Creighton University. The semen was not diluted at all for the two intradermal injections. I collected a sample and immediately put it in the freezer (in a glass jar). I did this about a week before the test. A couple hours before the test, I moved the sample to the fridge and thawed it. I then put it on ice for the drive to the doctor's office. It remained on ice until it was injected. When it was injected, it looked fresh.
I seem to get POIS when I get aroused...the symptoms are significantly worse after ejaculation than before, but if I masturbate or have sex without ejaculation or orgasm I still have the symptoms to a lesser degree.
I have a few questions for you guys...I am going to see my allergist this upcoming Friday and I am supposed to provide a "specimen" sample of my semen for skin ***** testing. So here are my questions:
1). How long before the skin ***** testing should I wait to provide the sample? The doctor said the morning of the appointment is fine (appt is at 10:00 a.m.). I know that sperm dies rather quickly after leaving the male body...will this affect the results of the test if I wait several hours?
2). If I do have a reaction to my own semen, will I have to provide a sample every time before I am giving the hyposensitization therapy? Or will they freeze the specimen and use it until they run out?
3). It seems like talk about treatment with autlogous semen has died down recently, is it still a viable treatment procedure?
4). What is the Kurtosis protocol I keep hearing about? I can't find any exact listing of what it entails as far as vitamins and procedure.
5). Are there any new procedures that have had success?
I feel like the issue is definitely based in the hypothalamus/pituitary. My theory is that I become aroused and my pre-ejaculate flows through my seminal "plumbing" and interacts with T-lymphocytes in any small gaps in the plumbing. If I ejaculate the amount of fluid interacting with the lymphocytes is increased causing a more severe reaction. The T-lymphocytes reaction then triggers the release of histamine. The histamine causes cortisol to be released to suppress it. A prolonged allergic reaction will create a prolonged cortisol release, interfering with hormones and the pituitary. Also, elevated levels of histamine will interact with the hypothalamus in a negative way, causing neurotransmitters and their release to become imbalanced and possibly even decreasing them.
My symptoms are very similar to dopamine deficiency, which I think might play a key role in POIS.
Anyways, I would appreciate any feedback and I hope you guys are doing well.
As I stated in my post describing the test experience, "...I received the p-r-i-c-k test as well as the intradermal injection tests since I wasn't entirely clear on which to ask for (Waldinger's study refers to "intracaneous injections" but calls it a p-r-i-c-k test.) Dr. Nguyen did not dilute the semen as Waldinger specified. The p-r-i-c-k tests showed a slight reaction (about 3x3mm wheal and erythema and a 5x5mm wheal and erythema). The intradermal reactions were huge. It was 25x30mm wheal and erythema and 15x30mm wheal and erythema. Waldinger says in his study that wheal and erythema less than 5mm is negative. (For those who don't know, the "wheal" is the red bump that appears and the "erythema" is the flaring out rash that surrounds the wheal. Measuring these two components gets the numbers I mentioned above). It's interesting to note that after the testing, I was hit by a bout of POIS fatigue and brain fog very quickly. Normally my POIS lingers for around 10 days. This time the symptoms hit me quick and hard. I fell into a deep sleep for an hour which helped symptoms. They didn't linger too badly."
Good luck! Please report your results (here, and on the other forum). Some people have uploaded photos of their test results, which might be good if you can pull it off too