I would like to know why my brain does not react to cannabis. I have tried edibles and they have no effect. lately I tried some caramels amounting to 30mg of TCH -THC? or whatever - the stuff that make syou high- and had no effect whatever.Why?
Males and females regulates cannabinoid-induced energy homeostasis differently:
- pmid 19427130
Females regulates brain energy homeostasis through estrogen-mediated attenuation of CB1 receptor:
- pmid 19758570
- pmid 22538462
This might help identifying sex differences in endocannabinoid mediated neurotransmission through proopiomelanocortin (POMC) synapses.