« on: 07/10/2017 16:54:20 »
Acidity causes your cells to mutate, disrupts the normal metabolism, causes the cells to break off to the blood stream and metastase.
Basically, DCA does this:
Inhibits PDK --> Cancer cells reduce their Warburg effect, normal metabolism is returned, less pyruvate to lactic acid
"Why acidity promotes oncogenesis. Warburg effect—increased glucose consumption, decreased oxidative phosphorylation, and accompanying lactate production
Your focus is on acidity, when it should be P53-mutations.
"TP53, which encodes the tumour-suppressor protein p53, is the most frequently mutated gene across all cancer types. The presence of mutant p53 predisposes to cancer development, promotes the survival of cancer cells, and is associated with ineffective therapeutic responses and unfavourable prognoses."
Nat Rev Clin Oncol. 2017 Sep 26. doi: 10.1038/nrclinonc.2017.151. Therapeutic targeting of p53: all mutants are equal, but some mutants are more equal than others.
DCA's anti-tumoral activity is primarily mediated by it's ability to induce transcriptional activation of P53 and it's target genes.
The increased pyruvate to lactate conversion in which you speak of occurs in tumors with mutant P53 status - which exhibit high glucose uptake as opposed to wild-type P53 status - but the P53 target-gene TIGAR, regulates glycolysis.... not the Warburg effect.