Yes, more news on the Silodosin.
The first times I tried it (daily 8mg doses followed by O), it successfully stopped ejaculation but had the unpleasant side-effect of making me feel sleepy all the time. Not POIS sleepy, just plain "I want a nap" sleepy, no brain fog.
I stopped taking the daily doses of Silodosin to see if it would work "on demand" (only taking the Silodosin before Os). My first experiment with this was last night, when I took half the recommended dose of Silodosin (1 4mg capsule) to see if it would be sufficient. Sadly, it wasn't - although the amount of semen ejaculated was far less than normal.
I will try another "on demand" test next weekend, this time taking the full 8mg dosage. I hope this will be successful, as I don't want to take alpha blockers every day.
If you are aiming for an 'on demand' dosing, it could be helpful to time it in accord with its build-up to its peak concentration:
Maximum plasma concentrations for silodosin were reached on average 2.6 hours after dosing.
Silodosin is readily absorbed from the gut, and peak plasma concentration (Cmax) and area under the curve (AUC) for plasma concentration versus time increase linearly with dose . Absolute bioavailability amounts to approximately 32% . Food blunts Cmax and delays time to Cmax by about 1 h without affecting the AUC. This feature has been exploited by recommending the administration of silodosin with food, ideally during breakfast in the morning, to avoid plasma concentration peaks that could potentially be associated with adverse effects , , and .